Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan

View ORCID ProfileCesheng Li, View ORCID ProfileDing Yu, Xiao Wu, Hong Liang, Zhijun Zhou, Yong Xie, View ORCID ProfileTaojing Li, View ORCID ProfileJunzheng Wu, Fengping Lu, Lu Feng, Min Mao, Lianzhen Lin, Huanhuan Guo, Shenglan Yue, Feifei Wang, Yan Peng, Yong Hu, Zejun Wang, Jianhong Yu, Yong Zhang, Jia Lu, Haoran Ning, Huichuan Yang, Daoxing Fu, Yanlin He, Dongbo Zhou, Tao Du, View ORCID ProfileKai Duan, Demei Dong, Kun Deng, Xia Zou, Ya Zhang, Rong Zhou, Yang Gao, Xinxin Zhang, View ORCID ProfileXiaoming Yang
doi: https://doi.org/10.1101/2021.04.05.437224
Cesheng Li
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Cesheng Li
Ding Yu
2Chengdu Rongsheng Pharmaceuticals Co., Ltd, 610041 Chengdu, China
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Ding Yu
Xiao Wu
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hong Liang
2Chengdu Rongsheng Pharmaceuticals Co., Ltd, 610041 Chengdu, China
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zhijun Zhou
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yong Xie
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Taojing Li
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Taojing Li
Junzheng Wu
2Chengdu Rongsheng Pharmaceuticals Co., Ltd, 610041 Chengdu, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Junzheng Wu
Fengping Lu
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lu Feng
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Min Mao
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lianzhen Lin
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Huanhuan Guo
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shenglan Yue
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Feifei Wang
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yan Peng
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yong Hu
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Zejun Wang
4China National Biotec Group Company Limited, 100029 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jianhong Yu
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yong Zhang
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jia Lu
4China National Biotec Group Company Limited, 100029 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Haoran Ning
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Huichuan Yang
5Wuhan Institute of Biological Products Co. Ltd., 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daoxing Fu
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yanlin He
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Dongbo Zhou
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
4China National Biotec Group Company Limited, 100029 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tao Du
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kai Duan
4China National Biotec Group Company Limited, 100029 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Kai Duan
Demei Dong
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kun Deng
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xia Zou
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ya Zhang
1Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd, 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rong Zhou
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yang Gao
3Beijing Tiantan Biological Products Co., Ltd, 100024 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xinxin Zhang
6Research Laboratory of Clinical Virology, Ruijin Hospital and Ruijin Hospital North, National Research Center for Translational Medicine, Shanghai Jiao Tong University of Medicine, 200025 Shanghai, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: zhangx@shsmu.edu.cn yangxiaoming@sinopharm.com
Xiaoming Yang
5Wuhan Institute of Biological Products Co. Ltd., 430207 Wuhan, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Xiaoming Yang
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Supplementary material
  • Preview PDF
Loading

Abstract

To investigate the duration of humoral immune response in convalescent coronavirus disease 2019 (COVID-19) patients, we conducted a 12-month longitudinal study through collecting a total of 1,782 plasma samples from 869 convalescent plasma donors in Wuhan, China and tested specific antibody response. The results show that positive rate of IgG antibody against receptor-binding domain of spike protein (RBD-IgG) to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the COVID-19 convalescent plasma donors exceeded 70% for 12 months post diagnosis. RBD-IgG kinetics displayed a gradually downward trend, the titer started to stabilize after 9 months and decreased by 68.1% compared with the 1st month. Moreover, male plasma donors produced more RBD-IgG than female plasma donors and patient age positively correlated with the RBD-IgG titer. A strong positive correlation between RBD-IgG and neutralizing antibody titers was also identified. This study is essential for understanding SARS-CoV-2-induced immune memory to develop vaccine and therapeutics.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
Back to top
PreviousNext
Posted April 05, 2021.
Download PDF

Supplementary Material

Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
Cesheng Li, Ding Yu, Xiao Wu, Hong Liang, Zhijun Zhou, Yong Xie, Taojing Li, Junzheng Wu, Fengping Lu, Lu Feng, Min Mao, Lianzhen Lin, Huanhuan Guo, Shenglan Yue, Feifei Wang, Yan Peng, Yong Hu, Zejun Wang, Jianhong Yu, Yong Zhang, Jia Lu, Haoran Ning, Huichuan Yang, Daoxing Fu, Yanlin He, Dongbo Zhou, Tao Du, Kai Duan, Demei Dong, Kun Deng, Xia Zou, Ya Zhang, Rong Zhou, Yang Gao, Xinxin Zhang, Xiaoming Yang
bioRxiv 2021.04.05.437224; doi: https://doi.org/10.1101/2021.04.05.437224
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Twelve-month specific IgG response to SARS-CoV-2 receptor-binding domain among COVID-19 convalescent plasma donors in Wuhan
Cesheng Li, Ding Yu, Xiao Wu, Hong Liang, Zhijun Zhou, Yong Xie, Taojing Li, Junzheng Wu, Fengping Lu, Lu Feng, Min Mao, Lianzhen Lin, Huanhuan Guo, Shenglan Yue, Feifei Wang, Yan Peng, Yong Hu, Zejun Wang, Jianhong Yu, Yong Zhang, Jia Lu, Haoran Ning, Huichuan Yang, Daoxing Fu, Yanlin He, Dongbo Zhou, Tao Du, Kai Duan, Demei Dong, Kun Deng, Xia Zou, Ya Zhang, Rong Zhou, Yang Gao, Xinxin Zhang, Xiaoming Yang
bioRxiv 2021.04.05.437224; doi: https://doi.org/10.1101/2021.04.05.437224

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Immunology
Subject Areas
All Articles
  • Animal Behavior and Cognition (4381)
  • Biochemistry (9581)
  • Bioengineering (7086)
  • Bioinformatics (24845)
  • Biophysics (12597)
  • Cancer Biology (9952)
  • Cell Biology (14346)
  • Clinical Trials (138)
  • Developmental Biology (7944)
  • Ecology (12101)
  • Epidemiology (2067)
  • Evolutionary Biology (15984)
  • Genetics (10921)
  • Genomics (14735)
  • Immunology (9869)
  • Microbiology (23645)
  • Molecular Biology (9477)
  • Neuroscience (50838)
  • Paleontology (369)
  • Pathology (1539)
  • Pharmacology and Toxicology (2681)
  • Physiology (4013)
  • Plant Biology (8655)
  • Scientific Communication and Education (1508)
  • Synthetic Biology (2391)
  • Systems Biology (6427)
  • Zoology (1346)