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Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike

Bailey Lubinski, Maureen H. V. Fernandes, Laura Frazier, Tiffany Tang, Susan Daniel, View ORCID ProfileDiego G. Diel, View ORCID ProfileJavier A. Jaimes, Gary R. Whittaker
doi: https://doi.org/10.1101/2021.04.06.438731
Bailey Lubinski
1Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
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Maureen H. V. Fernandes
2Department of Population Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
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Laura Frazier
1Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
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Tiffany Tang
3Robert Frederick Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA
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Susan Daniel
3Robert Frederick Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA
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Diego G. Diel
2Department of Population Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
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  • ORCID record for Diego G. Diel
Javier A. Jaimes
1Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
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  • For correspondence: jaj246@cornell.edu grw7@cornell.edu
Gary R. Whittaker
1Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
4Master of Public Health Program, Cornell University, Ithaca, NY, 14853, USA
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  • For correspondence: jaj246@cornell.edu grw7@cornell.edu
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Article Information

doi 
https://doi.org/10.1101/2021.04.06.438731
History 
  • November 1, 2021.

Article Versions

  • Version 1 (April 8, 2021 - 02:43).
  • You are viewing Version 2, the most recent version of this article.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Bailey Lubinski1,
  2. Maureen H. V. Fernandes2,
  3. Laura Frazier1,
  4. Tiffany Tang3,
  5. Susan Daniel3,
  6. Diego G. Diel2,
  7. Javier A. Jaimes1,* and
  8. Gary R. Whittaker1,4,*
  1. 1Department of Microbiology & Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
  2. 2Department of Population Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA
  3. 3Robert Frederick Smith School of Chemical & Biomolecular Engineering, Cornell University, Ithaca, NY, 14853, USA
  4. 4Master of Public Health Program, Cornell University, Ithaca, NY, 14853, USA
  1. ↵*Corresponding authors 618 Tower Rd., Ithaca NY 14853, USA, jaj246{at}cornell.edu; grw7{at}cornell.edu
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Posted November 01, 2021.
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Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike
Bailey Lubinski, Maureen H. V. Fernandes, Laura Frazier, Tiffany Tang, Susan Daniel, Diego G. Diel, Javier A. Jaimes, Gary R. Whittaker
bioRxiv 2021.04.06.438731; doi: https://doi.org/10.1101/2021.04.06.438731
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Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike
Bailey Lubinski, Maureen H. V. Fernandes, Laura Frazier, Tiffany Tang, Susan Daniel, Diego G. Diel, Javier A. Jaimes, Gary R. Whittaker
bioRxiv 2021.04.06.438731; doi: https://doi.org/10.1101/2021.04.06.438731

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