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Intrinsic Timescales Across the Basal Ganglia

View ORCID ProfileSimon Nougaret, View ORCID ProfileValeria Fascianelli, View ORCID ProfileSabrina Ravel, View ORCID ProfileAldo Genovesio
doi: https://doi.org/10.1101/2021.04.07.438040
Simon Nougaret
1Institut de Neurosciences de la Timone, UMR7289, Centre National de la Recherche Scientifique and Aix-Marseille Université, Marseille, France
2Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
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  • For correspondence: simon.nougaret@univ-amu.fr aldo.genovesio@uniroma1.it
Valeria Fascianelli
2Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
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Sabrina Ravel
1Institut de Neurosciences de la Timone, UMR7289, Centre National de la Recherche Scientifique and Aix-Marseille Université, Marseille, France
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Aldo Genovesio
2Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy
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  • For correspondence: simon.nougaret@univ-amu.fr aldo.genovesio@uniroma1.it
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Abstract

Recent studies have shown that neuronal stability over time can be estimated by the structure of the spike-count autocorrelation of neuronal populations. This estimation, called the intrinsic timescale, has been computed for several cortical areas and can be used to propose a cortical hierarchy reflecting a scale of temporal receptive windows between areas. In this study, we performed an autocorrelation analysis on neuronal populations of three basal ganglia (BG) nuclei, including the striatum and the subthalamic nucleus (STN), the input structures of the BG, and the external globus pallidus (GPe). The analysis was performed during the baseline period of a motivational visuomotor task in which monkeys had to apply different amounts of force to receive a different amount of reward. We found that the striatum and the STN have longer intrinsic timescales than the GPe. Moreover, our results allow for the placement of these subcortical structures within the already-defined scale of cortical temporal receptive windows. Estimates of intrinsic timescales are important in adding further constraints in the development of computational models of the complex dynamics among these nuclei and throughout cortico-BG-thalamo-cortical loops.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Email address of each author, Simon Nougaret : simon.nougaret{at}univ-amu.fr, Valeria Fascianelli : vf2266{at}columbia.edu, Sabrina Ravel : sabrina.ravel{at}univ-amu.fr, Aldo Genovesio : aldo.genovesio{at}uniroma1.it

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted April 07, 2021.
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Intrinsic Timescales Across the Basal Ganglia
Simon Nougaret, Valeria Fascianelli, Sabrina Ravel, Aldo Genovesio
bioRxiv 2021.04.07.438040; doi: https://doi.org/10.1101/2021.04.07.438040
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Intrinsic Timescales Across the Basal Ganglia
Simon Nougaret, Valeria Fascianelli, Sabrina Ravel, Aldo Genovesio
bioRxiv 2021.04.07.438040; doi: https://doi.org/10.1101/2021.04.07.438040

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