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Consolidation of human skill linked to waking hippocampo-neocortical replay

View ORCID ProfileER Buch, L Claudino, R Quentin, M Bönstrup, LG Cohen
doi: https://doi.org/10.1101/2021.04.07.438819
ER Buch
1Human Cortical Physiology and Neurorehabilitation Section, NINDS, NIH, Bethesda, MD, USA
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  • For correspondence: ethan.buch@nih.gov cohenl@ninds.nih.gov
L Claudino
1Human Cortical Physiology and Neurorehabilitation Section, NINDS, NIH, Bethesda, MD, USA
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R Quentin
1Human Cortical Physiology and Neurorehabilitation Section, NINDS, NIH, Bethesda, MD, USA
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M Bönstrup
1Human Cortical Physiology and Neurorehabilitation Section, NINDS, NIH, Bethesda, MD, USA
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LG Cohen
1Human Cortical Physiology and Neurorehabilitation Section, NINDS, NIH, Bethesda, MD, USA
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Summary

The introduction of rest intervals interspersed with practice strengthens wakeful consolidation of skill. The mechanisms by which the brain binds discrete action representations into consolidated, highly temporally-resolved skill sequences during waking rest are not known. To address this question, we recorded magnetoencephalography (MEG) during acquisition and rapid consolidation of a sequential motor skill. We report the presence of highly prominent, fast waking neural replay during the same rest periods in which rapid consolidation occurs. The observed replay was temporally compressed by approximately 20x relative to the acquired skill, occurred in both forward and reverse directions, was selective for the trained sequence and predicted the magnitude of skill consolidation. Replay representations extended beyond the hippocampus and entrorhinal cortex to the contralateral sensorimotor cortex. These results document the presence of robust hippocampo-neocortical replay supporting rapid wakeful consolidation of skill.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
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Posted April 07, 2021.
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Consolidation of human skill linked to waking hippocampo-neocortical replay
ER Buch, L Claudino, R Quentin, M Bönstrup, LG Cohen
bioRxiv 2021.04.07.438819; doi: https://doi.org/10.1101/2021.04.07.438819
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Consolidation of human skill linked to waking hippocampo-neocortical replay
ER Buch, L Claudino, R Quentin, M Bönstrup, LG Cohen
bioRxiv 2021.04.07.438819; doi: https://doi.org/10.1101/2021.04.07.438819

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