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The homology analysis of ACE2 gene and its distinct expression in laboratory and wild animals

Gang Wang, A-Mei Zhang, Binghui Wang, Jianhua Yin, Yue Feng, View ORCID Profilezulqarnain Baloch, Xueshan Xia
doi: https://doi.org/10.1101/2021.04.08.439088
Gang Wang
1Faculty of Life Science and Technology & Yunnan Provincial Center for Molecular Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China
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A-Mei Zhang
1Faculty of Life Science and Technology & Yunnan Provincial Center for Molecular Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China
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Binghui Wang
1Faculty of Life Science and Technology & Yunnan Provincial Center for Molecular Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China
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Jianhua Yin
1Faculty of Life Science and Technology & Yunnan Provincial Center for Molecular Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China
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Yue Feng
1Faculty of Life Science and Technology & Yunnan Provincial Center for Molecular Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China
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zulqarnain Baloch
1Faculty of Life Science and Technology & Yunnan Provincial Center for Molecular Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China
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  • ORCID record for zulqarnain Baloch
  • For correspondence: oliverxia2000@aliyun.com znbalooch@yahoo.com
Xueshan Xia
1Faculty of Life Science and Technology & Yunnan Provincial Center for Molecular Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China
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  • For correspondence: oliverxia2000@aliyun.com znbalooch@yahoo.com
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Abstract

Angiotensin-converting enzyme-2 (ACE2) has been recognized as an entry receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the host cells while bats has been suspected as natural host of SARS-CoV-2. However, the detail of intermediate host or the route of transmission of SARS-CoV-2 is still unclear. In this study, we analyze the conservation of ACE2 gene in 11 laboratory and wild animals that live in close proximity either with Bats or human and further investigated its RNA and protein expression pattern in wild bats, mice and tree shrew. We verified that the wild-bats and mice were belonged to Hipposideros pomona and Rattus norvegicus, respectively. ACE2 gene is highly conserved among all 11 animals species at the DNA level. Phylogenetic analysis based on the ACE2 nucleotide sequences revealed that wild bat and Tree shrew were forming a cluster close to human. We further report that ACE2 RNA expression pattern is highly species-specific in different tissues of different animals. Most notably, we found that the expression pattern of ACE2 RNA and protein are very different in each animal species. In summary, our results suggested that ACE2 gene is highly conserved among all 11 animals species. However, different relative expression pattern of ACE2 RNA and protein in each animal species is interesting. Further research is needed to clarify the possible connection between different relative expression pattern of ACE2 RNA and protein in different laboratory and wild animal species and the susceptibility to SARS-CoV-2 infection.

Competing Interest Statement

The authors have declared no competing interest.

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Posted April 10, 2021.
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The homology analysis of ACE2 gene and its distinct expression in laboratory and wild animals
Gang Wang, A-Mei Zhang, Binghui Wang, Jianhua Yin, Yue Feng, zulqarnain Baloch, Xueshan Xia
bioRxiv 2021.04.08.439088; doi: https://doi.org/10.1101/2021.04.08.439088
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The homology analysis of ACE2 gene and its distinct expression in laboratory and wild animals
Gang Wang, A-Mei Zhang, Binghui Wang, Jianhua Yin, Yue Feng, zulqarnain Baloch, Xueshan Xia
bioRxiv 2021.04.08.439088; doi: https://doi.org/10.1101/2021.04.08.439088

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