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Atypical N-glycosylation of SARS-CoV-2 impairs the efficient binding of Spike-RBM to the human-host receptor hACE2

View ORCID ProfileGustavo Gámez, View ORCID ProfileJuan A. Hermoso, View ORCID ProfileCésar Carrasco-López, View ORCID ProfileAlejandro Gómez-Mejia, View ORCID ProfileCarlos E. Muskus, View ORCID ProfileSven Hammerschmidt
doi: https://doi.org/10.1101/2021.04.09.439154
Gustavo Gámez
1Genetics, Regeneration and Cancer (GRC) Research Group, University Research Center (SIU), University of Antioquia, UdeA, 050010 Medellín, Colombia
2Basic and Applied Microbiology (MICROBA) Research Group, School of Microbiology, University of Antioquia, UdeA, 050010 Medellín, Colombia
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  • For correspondence: gustavo.gamez@udea.edu.co
Juan A. Hermoso
3Department of Crystallography and Structural Biology, Institute of Physical Chemistry “Rocasolano”, CSIC, 28006 Madrid, Spain
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César Carrasco-López
4Department of Chemical and Biological Engineering, Princeton University, Princeton NJ 08544
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Alejandro Gómez-Mejia
5Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8091, Zurich, Switzerland
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Carlos E. Muskus
6Program for the Study and Control of Tropical Diseases-PECET, Faculty of Medicine, University of Antioquia, 050010 Medellín, Colombia
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Sven Hammerschmidt
7Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, 17487 Greifswald, Germany
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Article Information

doi 
https://doi.org/10.1101/2021.04.09.439154
History 
  • April 10, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Gustavo Gámez1,2,*,
  2. Juan A. Hermoso3,
  3. César Carrasco-López4,
  4. Alejandro Gómez-Mejia5,
  5. Carlos E. Muskus6 and
  6. Sven Hammerschmidt7
  1. 1Genetics, Regeneration and Cancer (GRC) Research Group, University Research Center (SIU), University of Antioquia, UdeA, 050010 Medellín, Colombia
  2. 2Basic and Applied Microbiology (MICROBA) Research Group, School of Microbiology, University of Antioquia, UdeA, 050010 Medellín, Colombia
  3. 3Department of Crystallography and Structural Biology, Institute of Physical Chemistry “Rocasolano”, CSIC, 28006 Madrid, Spain
  4. 4Department of Chemical and Biological Engineering, Princeton University, Princeton NJ 08544
  5. 5Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, 8091, Zurich, Switzerland
  6. 6Program for the Study and Control of Tropical Diseases-PECET, Faculty of Medicine, University of Antioquia, 050010 Medellín, Colombia
  7. 7Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, 17487 Greifswald, Germany
  1. ↵*Corresponding author. E-mail: gustavo.gamez{at}udea.edu.co
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Atypical N-glycosylation of SARS-CoV-2 impairs the efficient binding of Spike-RBM to the human-host receptor hACE2
Gustavo Gámez, Juan A. Hermoso, César Carrasco-López, Alejandro Gómez-Mejia, Carlos E. Muskus, Sven Hammerschmidt
bioRxiv 2021.04.09.439154; doi: https://doi.org/10.1101/2021.04.09.439154
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Atypical N-glycosylation of SARS-CoV-2 impairs the efficient binding of Spike-RBM to the human-host receptor hACE2
Gustavo Gámez, Juan A. Hermoso, César Carrasco-López, Alejandro Gómez-Mejia, Carlos E. Muskus, Sven Hammerschmidt
bioRxiv 2021.04.09.439154; doi: https://doi.org/10.1101/2021.04.09.439154

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