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Direct and indirect pathway neurons in ventrolateral striatum differentially regulate licking movement and nigral responses

Zhaorong Chen, Zhi-Yu Zhang, Wen Zhang, Taorong Xie, Yaping Li, Xiao-Hong Xu, View ORCID ProfileHaishan Yao
doi: https://doi.org/10.1101/2021.04.11.439386
Zhaorong Chen
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Zhi-Yu Zhang
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
2University of Chinese Academy of Sciences, Beijing 100049, China
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Wen Zhang
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Taorong Xie
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Yaping Li
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
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Xiao-Hong Xu
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
3Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China
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Haishan Yao
1Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China
3Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology, Shanghai 201210, China
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  • ORCID record for Haishan Yao
  • For correspondence: haishanyao@ion.ac.cn
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SUMMARY

Drinking behavior in rodents is characterized by stereotyped, rhythmic licking movement, which is regulated by the basal ganglia. It is unclear how direct and indirect pathways control the lick bout and individual spout contact. We find that inactivating D1 and D2 receptors-expressing medium spiny neurons (MSNs) in the ventrolateral striatum (VLS) oppositely alters the number of licks in a bout. D1- and D2-MSNs exhibit different patterns of lick sequence-related activity and different phases of oscillation time-locked to the lick cycle. On timescale of a lick cycle, transient inactivation of D1-MSNs during tongue protrusion reduces spout contact probability, whereas transiently inactivating D2-MSNs has no effect. On timescale of a lick bout, inactivation of D1-MSNs (D2-MSNs) causes rate increase (decrease) in a subset of basal ganglia output neurons that decrease firing during licking. Our results reveal the distinct roles of D1- and D2-MSNs in regulating licking at both coarse and fine timescales.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted August 04, 2021.
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Direct and indirect pathway neurons in ventrolateral striatum differentially regulate licking movement and nigral responses
Zhaorong Chen, Zhi-Yu Zhang, Wen Zhang, Taorong Xie, Yaping Li, Xiao-Hong Xu, Haishan Yao
bioRxiv 2021.04.11.439386; doi: https://doi.org/10.1101/2021.04.11.439386
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Direct and indirect pathway neurons in ventrolateral striatum differentially regulate licking movement and nigral responses
Zhaorong Chen, Zhi-Yu Zhang, Wen Zhang, Taorong Xie, Yaping Li, Xiao-Hong Xu, Haishan Yao
bioRxiv 2021.04.11.439386; doi: https://doi.org/10.1101/2021.04.11.439386

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