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LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients
Giuseppe Bombaci, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Eric Chi-Wang Yu, Gillian M. Mackie, Matthew Pugh, Vedat Burak Ozan, Yara Banz, Thibaud Spinetti, Cedric Hirzel, Esther Youd, Joerg C. Schefold, Graham Taylor, Amiq Gazdhar, View ORCID ProfileNicolas Bonadies, Anne Angelillo-Scherrer, Pascal Schneider, Kendle M. Maslowski, View ORCID ProfileRamanjaneyulu Allam
doi: https://doi.org/10.1101/2021.04.12.438219
Giuseppe Bombaci
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland
2Department for BioMedical Research, University of Bern, Switzerland
3Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern, Switzerland
Mayuresh Anant Sarangdhar
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland
2Department for BioMedical Research, University of Bern, Switzerland
Nicola Andina
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland
2Department for BioMedical Research, University of Bern, Switzerland
Aubry Tardivel
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland
2Department for BioMedical Research, University of Bern, Switzerland
Eric Chi-Wang Yu
4Department of Biochemistry, University of Lausanne, Lausanne, Switzerland
Gillian M. Mackie
5Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
6Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Matthew Pugh
5Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
Vedat Burak Ozan
2Department for BioMedical Research, University of Bern, Switzerland
11Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
Yara Banz
7Institute of Pathology, University of Bern, Switzerland
Thibaud Spinetti
8Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
Cedric Hirzel
9Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern, Switzerland
Esther Youd
10School of Medicine, Dentistry & Nursing, Forensic Medicine and Science. University of Glasgow, Scotland, UK
Joerg C. Schefold
8Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
Graham Taylor
5Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
Amiq Gazdhar
2Department for BioMedical Research, University of Bern, Switzerland
11Department of Pulmonary Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
Nicolas Bonadies
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland
2Department for BioMedical Research, University of Bern, Switzerland
Anne Angelillo-Scherrer
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland
2Department for BioMedical Research, University of Bern, Switzerland
Pascal Schneider
4Department of Biochemistry, University of Lausanne, Lausanne, Switzerland
Kendle M. Maslowski
5Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK
6Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK
Ramanjaneyulu Allam
1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Switzerland
2Department for BioMedical Research, University of Bern, Switzerland
Posted August 26, 2021.
LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients
Giuseppe Bombaci, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Eric Chi-Wang Yu, Gillian M. Mackie, Matthew Pugh, Vedat Burak Ozan, Yara Banz, Thibaud Spinetti, Cedric Hirzel, Esther Youd, Joerg C. Schefold, Graham Taylor, Amiq Gazdhar, Nicolas Bonadies, Anne Angelillo-Scherrer, Pascal Schneider, Kendle M. Maslowski, Ramanjaneyulu Allam
bioRxiv 2021.04.12.438219; doi: https://doi.org/10.1101/2021.04.12.438219
LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients
Giuseppe Bombaci, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Eric Chi-Wang Yu, Gillian M. Mackie, Matthew Pugh, Vedat Burak Ozan, Yara Banz, Thibaud Spinetti, Cedric Hirzel, Esther Youd, Joerg C. Schefold, Graham Taylor, Amiq Gazdhar, Nicolas Bonadies, Anne Angelillo-Scherrer, Pascal Schneider, Kendle M. Maslowski, Ramanjaneyulu Allam
bioRxiv 2021.04.12.438219; doi: https://doi.org/10.1101/2021.04.12.438219
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