Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

View ORCID ProfileCatherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, View ORCID ProfileLewis E Kay, View ORCID ProfileGregory R Bowman
doi: https://doi.org/10.1101/2021.04.14.439842
Catherine R Knoverek
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Catherine R Knoverek
Upasana L Mallimadugula
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sukrit Singh
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Enrico Rennella
2Department of Molecular Genetics, The University of Toronto, Toronto, Canada
3Department of Biochemistry, The University of Toronto, Toronto, Canada
4Department of Chemistry, The University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas E Frederick
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tairan Yuwen
5Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University, Beijing, China
6State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shreya Raavicharla
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lewis E Kay
2Department of Molecular Genetics, The University of Toronto, Toronto, Canada
3Department of Biochemistry, The University of Toronto, Toronto, Canada
4Department of Chemistry, The University of Toronto, Toronto, Canada
7Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lewis E Kay
Gregory R Bowman
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
8Center for the Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gregory R Bowman
  • For correspondence: g.bowman@wustl.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Article Information

doi 
https://doi.org/10.1101/2021.04.14.439842
History 
  • April 14, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Catherine R Knoverek1,
  2. Upasana L Mallimadugula1,
  3. Sukrit Singh1,
  4. Enrico Rennella2,3,4,
  5. Thomas E Frederick1,
  6. Tairan Yuwen5,6,
  7. Shreya Raavicharla1,
  8. Lewis E Kay2,3,4,7 and
  9. Gregory R Bowman1,8,*
  1. 1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  2. 2Department of Molecular Genetics, The University of Toronto, Toronto, Canada
  3. 3Department of Biochemistry, The University of Toronto, Toronto, Canada
  4. 4Department of Chemistry, The University of Toronto, Toronto, Canada
  5. 5Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University, Beijing, China
  6. 6State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing, China
  7. 7Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada
  8. 8Center for the Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, United States
  1. ↵* Corresponding author; email: g.bowman{at}wustl.edu
Back to top
PreviousNext
Posted April 14, 2021.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman
bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman
bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biophysics
Subject Areas
All Articles
  • Animal Behavior and Cognition (4397)
  • Biochemistry (9619)
  • Bioengineering (7114)
  • Bioinformatics (24917)
  • Biophysics (12644)
  • Cancer Biology (9982)
  • Cell Biology (14390)
  • Clinical Trials (138)
  • Developmental Biology (7981)
  • Ecology (12136)
  • Epidemiology (2067)
  • Evolutionary Biology (16012)
  • Genetics (10941)
  • Genomics (14768)
  • Immunology (9891)
  • Microbiology (23720)
  • Molecular Biology (9495)
  • Neuroscience (51027)
  • Paleontology (370)
  • Pathology (1544)
  • Pharmacology and Toxicology (2688)
  • Physiology (4031)
  • Plant Biology (8687)
  • Scientific Communication and Education (1512)
  • Synthetic Biology (2403)
  • Systems Biology (6450)
  • Zoology (1346)