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Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
View ORCID ProfileCatherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, View ORCID ProfileLewis E Kay, View ORCID ProfileGregory R Bowman
doi: https://doi.org/10.1101/2021.04.14.439842
Catherine R Knoverek
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
Upasana L Mallimadugula
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
Sukrit Singh
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
Enrico Rennella
2Department of Molecular Genetics, The University of Toronto, Toronto, Canada
3Department of Biochemistry, The University of Toronto, Toronto, Canada
4Department of Chemistry, The University of Toronto, Toronto, Canada
Thomas E Frederick
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
Tairan Yuwen
5Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University, Beijing, China
6State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing, China
Shreya Raavicharla
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
Lewis E Kay
2Department of Molecular Genetics, The University of Toronto, Toronto, Canada
3Department of Biochemistry, The University of Toronto, Toronto, Canada
4Department of Chemistry, The University of Toronto, Toronto, Canada
7Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada
Gregory R Bowman
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
8Center for the Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, United States

Article usage
Posted April 14, 2021.
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman
bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman
bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842
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