Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

Catherine R Knoverek; Upasana L Mallimadugula; Sukrit Singh; Enrico Rennella; Thomas E Frederick; Tairan Yuwen; Shreya Raavicharla; Lewis E Kay; Gregory R Bowman

doi:10.1101/2021.04.14.439842

New Results

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

View ORCID ProfileCatherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, View ORCID ProfileLewis E Kay, View ORCID ProfileGregory R Bowman

doi: https://doi.org/10.1101/2021.04.14.439842

Catherine R Knoverek

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Catherine R Knoverek

Upasana L Mallimadugula

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sukrit Singh

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Enrico Rennella

2Department of Molecular Genetics, The University of Toronto, Toronto, Canada

3Department of Biochemistry, The University of Toronto, Toronto, Canada

4Department of Chemistry, The University of Toronto, Toronto, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Thomas E Frederick

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tairan Yuwen

5Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University, Beijing, China

6State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing, China

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Shreya Raavicharla

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Lewis E Kay

2Department of Molecular Genetics, The University of Toronto, Toronto, Canada

3Department of Biochemistry, The University of Toronto, Toronto, Canada

4Department of Chemistry, The University of Toronto, Toronto, Canada

7Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Lewis E Kay

Gregory R Bowman

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

8Center for the Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Gregory R Bowman
For correspondence: g.bowman@wustl.edu

Abstract
Full Text
Info/History
Metrics
Preview PDF

Article usage

Article usage: April 2021 to July 2021

	Abstract	Full	Pdf
Apr 2021	844	34	168
May 2021	412	21	83
Jun 2021	150	23	53
Jul 2021	84	15	27

View the discussion thread.

PreviousNext

Posted April 14, 2021.

Download PDF

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

Message Subject (Your Name) has forwarded a page to you from bioRxiv

Message Body (Your Name) thought you would like to see this page from the bioRxiv website.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman

bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842

Share This Article:

Citation Tools

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman

bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842

Citation Manager Formats

BibTeX
Bookends
EasyBib
EndNote (tagged)
EndNote 8 (xml)
Medlars
Mendeley
Papers
RefWorks Tagged
Ref Manager
RIS
Zotero

Tweet Widget
Facebook Like
Google Plus One

Subject Area

Biophysics

Subject Areas

All Articles

Animal Behavior and Cognition (2868)
Biochemistry (5798)
Bioengineering (4113)
Bioinformatics (16977)
Biophysics (7995)
Cancer Biology (6171)
Cell Biology (8949)
Clinical Trials (138)
Developmental Biology (5203)
Ecology (8183)
Epidemiology (2062)
Evolutionary Biology (11297)
Genetics (8184)
Genomics (10859)
Immunology (5845)
Microbiology (15364)
Molecular Biology (5925)
Neuroscience (33625)
Paleontology (237)
Pathology (975)
Pharmacology and Toxicology (1668)
Physiology (2472)
Plant Biology (5495)
Scientific Communication and Education (1107)
Synthetic Biology (1528)
Systems Biology (4494)
Zoology (892)