Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

Catherine R Knoverek; Upasana L Mallimadugula; Sukrit Singh; Enrico Rennella; Thomas E Frederick; Tairan Yuwen; Shreya Raavicharla; Lewis E Kay; Gregory R Bowman

doi:10.1101/2021.04.14.439842

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Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

View ORCID ProfileCatherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, View ORCID ProfileLewis E Kay, View ORCID ProfileGregory R Bowman

doi: https://doi.org/10.1101/2021.04.14.439842

Catherine R Knoverek

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

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ORCID record for Catherine R Knoverek

Upasana L Mallimadugula

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

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Sukrit Singh

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

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Enrico Rennella

2Department of Molecular Genetics, The University of Toronto, Toronto, Canada

3Department of Biochemistry, The University of Toronto, Toronto, Canada

4Department of Chemistry, The University of Toronto, Toronto, Canada

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Thomas E Frederick

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

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Tairan Yuwen

5Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University, Beijing, China

6State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing, China

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Shreya Raavicharla

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

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Lewis E Kay

2Department of Molecular Genetics, The University of Toronto, Toronto, Canada

3Department of Biochemistry, The University of Toronto, Toronto, Canada

4Department of Chemistry, The University of Toronto, Toronto, Canada

7Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada

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ORCID record for Lewis E Kay

Gregory R Bowman

1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States

8Center for the Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, United States

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ORCID record for Gregory R Bowman
For correspondence: g.bowman@wustl.edu

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Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman

bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842

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Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman

bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842

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