Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity

View ORCID ProfileCatherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, View ORCID ProfileLewis E Kay, View ORCID ProfileGregory R Bowman
doi: https://doi.org/10.1101/2021.04.14.439842
Catherine R Knoverek
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Catherine R Knoverek
Upasana L Mallimadugula
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sukrit Singh
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Enrico Rennella
2Department of Molecular Genetics, The University of Toronto, Toronto, Canada
3Department of Biochemistry, The University of Toronto, Toronto, Canada
4Department of Chemistry, The University of Toronto, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas E Frederick
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tairan Yuwen
5Department of Pharmaceutical Analysis, School of Pharmaceutical Sciences, Peking University, Beijing, China
6State Key Laboratory of Nature and Biomimetic Drugs, Peking University, Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Shreya Raavicharla
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lewis E Kay
2Department of Molecular Genetics, The University of Toronto, Toronto, Canada
3Department of Biochemistry, The University of Toronto, Toronto, Canada
4Department of Chemistry, The University of Toronto, Toronto, Canada
7Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lewis E Kay
Gregory R Bowman
1Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, United States
8Center for the Science and Engineering of Living Systems, Washington University in St. Louis, St. Louis, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gregory R Bowman
  • For correspondence: g.bowman@wustl.edu
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Preview PDF
Loading

Article usage

Article usage: April 2021 to May 2023

AbstractFullPdf
Apr 202184434168
May 20214122183
Jun 20211502353
Jul 2021852028
Aug 2021461222
Sep 202158928
Oct 2021807110
Nov 202198946
Dec 202133119
Jan 202270525
Feb 20222457
Mar 20221407
Apr 20222877
May 202211212
Jun 20221004
Jul 20223114
Aug 20221807
Sep 202210010
Oct 20221615
Nov 20221915
Dec 2022925
Jan 2023852
Feb 2023533
Mar 2023108
Apr 20231005
May 2023901
Back to top
PreviousNext
Posted April 14, 2021.
Download PDF
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman
bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Opening of a Cryptic Pocket in β-lactamase Increases Penicillinase Activity
Catherine R Knoverek, Upasana L Mallimadugula, Sukrit Singh, Enrico Rennella, Thomas E Frederick, Tairan Yuwen, Shreya Raavicharla, Lewis E Kay, Gregory R Bowman
bioRxiv 2021.04.14.439842; doi: https://doi.org/10.1101/2021.04.14.439842

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Biophysics
Subject Areas
All Articles
  • Animal Behavior and Cognition (4380)
  • Biochemistry (9571)
  • Bioengineering (7084)
  • Bioinformatics (24831)
  • Biophysics (12595)
  • Cancer Biology (9946)
  • Cell Biology (14334)
  • Clinical Trials (138)
  • Developmental Biology (7943)
  • Ecology (12095)
  • Epidemiology (2067)
  • Evolutionary Biology (15980)
  • Genetics (10915)
  • Genomics (14730)
  • Immunology (9862)
  • Microbiology (23636)
  • Molecular Biology (9472)
  • Neuroscience (50824)
  • Paleontology (369)
  • Pathology (1538)
  • Pharmacology and Toxicology (2678)
  • Physiology (4009)
  • Plant Biology (8653)
  • Scientific Communication and Education (1508)
  • Synthetic Biology (2389)
  • Systems Biology (6422)
  • Zoology (1345)