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Opposing roles of the dorsolateral and dorsomedial striatum in the acquisition of skilled action sequencing in rats

View ORCID ProfileKarly M. Turner, Anna Svegborn, View ORCID ProfileMia Langguth, Colin McKenzie, View ORCID ProfileTrevor W. Robbins
doi: https://doi.org/10.1101/2021.04.15.439935
Karly M. Turner
1School of Psychology, University of New South Wales, Sydney, Australia
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  • For correspondence: karly.turner@unsw.edu.au
Anna Svegborn
2Lund University, Lund, Sweden
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Mia Langguth
3School of Psychology, The University of Sydney, Sydney, Australia
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Colin McKenzie
4Department of Psychology, University of Cambridge, Cambridge, United Kingdom
5Behavioural and Cognitive Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
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Trevor W. Robbins
4Department of Psychology, University of Cambridge, Cambridge, United Kingdom
5Behavioural and Cognitive Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
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ABSTRACT

The shift in control from dorsomedial to dorsolateral striatum during skill and habit formation has been well established, but whether striatal subregions orchestrate this shift co-operatively or competitively remains unclear. Cortical inputs have also been implicated in the shift towards automaticity, but it is unknown if they mirror their downstream striatal targets across this transition. We addressed these questions using a five-step heterogeneous action sequencing task in rats that is optimally performed by automated chains of actions. By optimising automatic habitual responding, we discovered that loss of function in the dorsomedial striatum accelerated sequence acquisition. In contrast, loss of function in the dorsolateral striatum impeded acquisition of sequencing, demonstrating functional opposition within the striatum. Unexpectedly the medial prefrontal cortex was not involved, however the lateral orbitofrontal cortex was critical. These results shift current theories about striatal control of behavior to a model of competitive opposition, where the dorsomedial striatum acts in a gating role to inhibit dorsolateral-striatum driven behavior.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted September 09, 2021.
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Opposing roles of the dorsolateral and dorsomedial striatum in the acquisition of skilled action sequencing in rats
Karly M. Turner, Anna Svegborn, Mia Langguth, Colin McKenzie, Trevor W. Robbins
bioRxiv 2021.04.15.439935; doi: https://doi.org/10.1101/2021.04.15.439935
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Opposing roles of the dorsolateral and dorsomedial striatum in the acquisition of skilled action sequencing in rats
Karly M. Turner, Anna Svegborn, Mia Langguth, Colin McKenzie, Trevor W. Robbins
bioRxiv 2021.04.15.439935; doi: https://doi.org/10.1101/2021.04.15.439935

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