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Rigidifying a de novo enzyme increases activity and induces a negative activation heat capacity
SA Hindson, HA Bunzel, B Frank, DA Svistunenko, C Williams, MW van der Kamp, View ORCID ProfileAJ Mulholland, View ORCID ProfileCR Pudney, JLR Anderson
doi: https://doi.org/10.1101/2021.04.16.439788
SA Hindson
1Department of Biology and Biochemistry, Centre for Sustainable Chemical Technology, University of Bath, Bath BA2 7AY, UK
HA Bunzel
2School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
3Centre for Computational Chemistry, University of Bristol, Bristol BS8 1TS, UK
B Frank
2School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
4Bristol Centre for Functional Nanomaterials, School of Physics, University of Bristol, Bristol BS8 1TL, UK
DA Svistunenko
5School of Life Sciences, University of Essex, Colchester CO4 3SQ, UK
C Williams
3Centre for Computational Chemistry, University of Bristol, Bristol BS8 1TS, UK
MW van der Kamp
2School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
AJ Mulholland
3Centre for Computational Chemistry, University of Bristol, Bristol BS8 1TS, UK
CR Pudney
1Department of Biology and Biochemistry, Centre for Sustainable Chemical Technology, University of Bath, Bath BA2 7AY, UK
JLR Anderson
2School of Biochemistry, University of Bristol, Bristol BS8 1TD, UK
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Posted April 16, 2021.
Rigidifying a de novo enzyme increases activity and induces a negative activation heat capacity
SA Hindson, HA Bunzel, B Frank, DA Svistunenko, C Williams, MW van der Kamp, AJ Mulholland, CR Pudney, JLR Anderson
bioRxiv 2021.04.16.439788; doi: https://doi.org/10.1101/2021.04.16.439788
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