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Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors In Vitro and In Vivo
View ORCID ProfileJJ Patten, View ORCID ProfileP. T. Keiser, View ORCID ProfileD. Gysi, View ORCID ProfileG. Menichetti, H. Mori, View ORCID ProfileC. J. Donahue, View ORCID ProfileX. Gan, I. Do Valle, K. Geoghegan-Barek, View ORCID ProfileM. Anantpadma, J. L. Berrigan, S. Jalloh, View ORCID ProfileT. Ayazika, View ORCID ProfileF. Wagner, M. Zitnik, View ORCID ProfileS. Ayehunie, D. Anderson, J. Loscalzo, S. Gummuluru, View ORCID ProfileM. N. Namchuk, View ORCID ProfileA. L. Barabasi, View ORCID ProfileR. A. Davey
doi: https://doi.org/10.1101/2021.04.20.440626
JJ Patten
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
P. T. Keiser
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
D. Gysi
2Center for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA
3Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
G. Menichetti
2Center for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA
3Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
H. Mori
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
C. J. Donahue
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
X. Gan
2Center for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA
3Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
I. Do Valle
2Center for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA
K. Geoghegan-Barek
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
M. Anantpadma
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
4Analytical Development, WuXi Advanced Therapies, Philadelphia, PA, 19112, USA
J. L. Berrigan
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
S. Jalloh
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
T. Ayazika
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
F. Wagner
6MatTek Corporation, Ashland, MA 01721, USA
M. Zitnik
2Center for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA
S. Ayehunie
6MatTek Corporation, Ashland, MA 01721, USA
D. Anderson
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
J. Loscalzo
3Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
S. Gummuluru
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
M. N. Namchuk
7Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA. 02115, USA
A. L. Barabasi
2Center for Complex Network Research, Northeastern University, Boston, Massachusetts 02115, USA
3Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
8Department of Network and Data Science, Central European University, Budapest 1051, Hungary
R. A. Davey
1Department of Microbiology, Boston University School of Medicine and NEIDL, Boston University, Boston, MA, 02118, USA
Posted April 20, 2021.
Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors In Vitro and In Vivo
JJ Patten, P. T. Keiser, D. Gysi, G. Menichetti, H. Mori, C. J. Donahue, X. Gan, I. Do Valle, K. Geoghegan-Barek, M. Anantpadma, J. L. Berrigan, S. Jalloh, T. Ayazika, F. Wagner, M. Zitnik, S. Ayehunie, D. Anderson, J. Loscalzo, S. Gummuluru, M. N. Namchuk, A. L. Barabasi, R. A. Davey
bioRxiv 2021.04.20.440626; doi: https://doi.org/10.1101/2021.04.20.440626
Multidose evaluation of 6,710 drug repurposing library identifies potent SARS-CoV-2 infection inhibitors In Vitro and In Vivo
JJ Patten, P. T. Keiser, D. Gysi, G. Menichetti, H. Mori, C. J. Donahue, X. Gan, I. Do Valle, K. Geoghegan-Barek, M. Anantpadma, J. L. Berrigan, S. Jalloh, T. Ayazika, F. Wagner, M. Zitnik, S. Ayehunie, D. Anderson, J. Loscalzo, S. Gummuluru, M. N. Namchuk, A. L. Barabasi, R. A. Davey
bioRxiv 2021.04.20.440626; doi: https://doi.org/10.1101/2021.04.20.440626
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