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Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter

Amanda Kowalczyk, Omotola Gbadamosi, Kathryn Kolor, Jahree Sosa, Claudette St Croix, Gregory Gibson, Maria Chikina, Elias Aizenman, Nathan Clark, Kirill Kiselyov
doi: https://doi.org/10.1101/2021.04.22.440839
Amanda Kowalczyk
1Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, USA, 15213
2Department of Computational and Systems Biology, University of Pittsburgh, USA, 15213
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Omotola Gbadamosi
3Department of Biological Science, University of Pittsburgh, USA, 15260
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Kathryn Kolor
3Department of Biological Science, University of Pittsburgh, USA, 15260
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Jahree Sosa
3Department of Biological Science, University of Pittsburgh, USA, 15260
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Claudette St Croix
4Center for Biologic Imaging, University of Pittsburgh, USA, 15260
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Gregory Gibson
4Center for Biologic Imaging, University of Pittsburgh, USA, 15260
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Maria Chikina
2Department of Computational and Systems Biology, University of Pittsburgh, USA, 15213
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Elias Aizenman
5Department of Neurobiology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260
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Nathan Clark
6Department of Human Genetics, University of Utah, USA, 84112
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  • For correspondence: nclark@utah.edu kiselyov@pitt.edu
Kirill Kiselyov
3Department of Biological Science, University of Pittsburgh, USA, 15260
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  • For correspondence: nclark@utah.edu kiselyov@pitt.edu
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Article Information

doi 
https://doi.org/10.1101/2021.04.22.440839
History 
  • April 22, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Amanda Kowalczyk1,2,
  2. Omotola Gbadamosi3,
  3. Kathryn Kolor3,
  4. Jahree Sosa3,
  5. Claudette St Croix4,
  6. Gregory Gibson4,
  7. Maria Chikina2,
  8. Elias Aizenman5,
  9. Nathan Clark6,* and
  10. Kirill Kiselyov3,*
  1. 1Joint Carnegie Mellon University-University of Pittsburgh PhD Program in Computational Biology, Pittsburgh, USA, 15213
  2. 2Department of Computational and Systems Biology, University of Pittsburgh, USA, 15213
  3. 3Department of Biological Science, University of Pittsburgh, USA, 15260
  4. 4Center for Biologic Imaging, University of Pittsburgh, USA, 15260
  5. 5Department of Neurobiology and Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260
  6. 6Department of Human Genetics, University of Utah, USA, 84112
  1. ↵*Address correspondence to: Nathan Clark, Department of Human Genetics, University of Utah, 15 S 2030 E / Salt Lake City, UT 84112, Phone: +1 (801) 587-0990, Email: nclark{at}utah.edu or Kirill Kiselyov, Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Ave, Pittsburgh, PA, USA, Phone: +1 (412) 624-4317, Email: kiselyov{at}pitt.edu
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Posted April 22, 2021.
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Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter
Amanda Kowalczyk, Omotola Gbadamosi, Kathryn Kolor, Jahree Sosa, Claudette St Croix, Gregory Gibson, Maria Chikina, Elias Aizenman, Nathan Clark, Kirill Kiselyov
bioRxiv 2021.04.22.440839; doi: https://doi.org/10.1101/2021.04.22.440839
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Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter
Amanda Kowalczyk, Omotola Gbadamosi, Kathryn Kolor, Jahree Sosa, Claudette St Croix, Gregory Gibson, Maria Chikina, Elias Aizenman, Nathan Clark, Kirill Kiselyov
bioRxiv 2021.04.22.440839; doi: https://doi.org/10.1101/2021.04.22.440839

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