Skip to main content
bioRxiv
  • Home
  • About
  • Submit
  • ALERTS / RSS
Advanced Search
New Results

Structuring time: The hippocampus constructs sequence memories that generalize temporal relations across experiences

View ORCID ProfileJacob L. S. Bellmund, View ORCID ProfileLorena Deuker, Nicole D. Montijn, View ORCID ProfileChristian F. Doeller
doi: https://doi.org/10.1101/2021.04.23.440002
Jacob L. S. Bellmund
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jacob L. S. Bellmund
  • For correspondence: bellmund@cbs.mpg.de
Lorena Deuker
2Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Lorena Deuker
Nicole D. Montijn
3Department of Clinical Psychology, Utrecht University, Utrecht, the Netherlands
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christian F. Doeller
1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
4Kavli Institute for Systems Neuroscience, Centre for Neural Computation, The Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Jebsen Centre for Alzheimer’s Disease, Norwegian University of Science and Technology, Trondheim, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Christian F. Doeller
  • Abstract
  • Full Text
  • Info/History
  • Metrics
  • Data/Code
  • Preview PDF
Loading

Abstract

The hippocampal-entorhinal region supports memory for episodic details, such as temporal relations of sequential events, and mnemonic constructions combining experiences for inferential reasoning. However, it is unclear whether hippocampal event memories reflect temporal relations derived from mnemonic constructions, event order, or elapsing time, and whether these sequence representations generalize temporal relations across similar sequences. Here, participants mnemonically constructed times of events from multiple sequences using infrequent cues and their experience of passing time. After learning, event representations in the anterior hippocampus reflected temporal relations based on constructed times. Temporal relations were generalized across sequences, revealing distinct representational formats for events from the same or different sequences. Structural knowledge about time patterns, abstracted from different sequences, biased the construction of specific event times. These findings demonstrate that mnemonic construction and the generalization of relational knowledge combine in the hippocampus, consistent with the simulation of scenarios from episodic details and structural knowledge.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Major Changes: Theoretical framework was revised. Addition of multidimensional scaling analysis.

  • https://jacbel.github.io/virtem_code/overview

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
Back to top
PreviousNext
Posted July 28, 2021.
Download PDF
Data/Code
Email

Thank you for your interest in spreading the word about bioRxiv.

NOTE: Your email address is requested solely to identify you as the sender of this article.

Enter multiple addresses on separate lines or separate them with commas.
Structuring time: The hippocampus constructs sequence memories that generalize temporal relations across experiences
(Your Name) has forwarded a page to you from bioRxiv
(Your Name) thought you would like to see this page from the bioRxiv website.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Structuring time: The hippocampus constructs sequence memories that generalize temporal relations across experiences
Jacob L. S. Bellmund, Lorena Deuker, Nicole D. Montijn, Christian F. Doeller
bioRxiv 2021.04.23.440002; doi: https://doi.org/10.1101/2021.04.23.440002
Reddit logo Twitter logo Facebook logo LinkedIn logo Mendeley logo
Citation Tools
Structuring time: The hippocampus constructs sequence memories that generalize temporal relations across experiences
Jacob L. S. Bellmund, Lorena Deuker, Nicole D. Montijn, Christian F. Doeller
bioRxiv 2021.04.23.440002; doi: https://doi.org/10.1101/2021.04.23.440002

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Subject Area

  • Neuroscience
Subject Areas
All Articles
  • Animal Behavior and Cognition (4246)
  • Biochemistry (9173)
  • Bioengineering (6806)
  • Bioinformatics (24064)
  • Biophysics (12157)
  • Cancer Biology (9565)
  • Cell Biology (13825)
  • Clinical Trials (138)
  • Developmental Biology (7660)
  • Ecology (11737)
  • Epidemiology (2066)
  • Evolutionary Biology (15544)
  • Genetics (10672)
  • Genomics (14362)
  • Immunology (9515)
  • Microbiology (22906)
  • Molecular Biology (9130)
  • Neuroscience (49152)
  • Paleontology (358)
  • Pathology (1487)
  • Pharmacology and Toxicology (2584)
  • Physiology (3851)
  • Plant Biology (8351)
  • Scientific Communication and Education (1473)
  • Synthetic Biology (2301)
  • Systems Biology (6206)
  • Zoology (1303)