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Diet Potentially Drives the Differentiation of Eating Behaviours via Alterations to the Gut Microbiome in Infants

View ORCID ProfileCathy Yan, View ORCID ProfileHelen Zhao, View ORCID ProfileNavika Nayar, View ORCID ProfileKyung E. Rhee, View ORCID ProfileJulie C. Lumeng
doi: https://doi.org/10.1101/2021.04.24.438478
Cathy Yan
1Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
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Helen Zhao
1Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
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Navika Nayar
1Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada
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Kyung E. Rhee
2Department of Pediatrics, UC San Diego School of Medicine, La Jolla, California
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Julie C. Lumeng
3Department of Pediatrics, University of Michigan Medical School, and Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan
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  • For correspondence: jlumeng@med.umich.edu
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ABSTRACT

Certain infant eating behaviours are associated with adverse health outcomes such as obesity. While a diet consisting of infant formula has been linked to higher-risk eating behaviours and changes in the gut microbiome, little is known about what role the gut microbiome plays in mediating eating behaviours. Using 16S rRNA sequences extracted from 96 fecal samples collected from 58 infants, we identified a subset of bacterial taxa that were more abundant in formula-fed infants, primarily composed of the phylum Firmicutes. The presence of these taxa correlated with a lower drive to eat (i.e., lower food responsiveness). Furthermore, short-chain fatty acid production pathways were significantly more abundant in formula-fed infants, negatively correlated with food responsiveness, and positively associated with relative abundance of the Firmicutes subset. Our results suggest that higher abundances of Firmicutes in formula-fed infants may decrease their food responsiveness through short-chain fatty acid production in the first four months of life. Taken together, these findings suggest a potential role for the infant’s diet in impacting eating behaviour via changes to the gut microbiome, which may lead to the development of novel interventions for the prevention of childhood obesity.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • Order of authorship updated

  • https://www.ebi.ac.uk/ena/browser/view/PRJEB39437

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted April 26, 2021.
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Diet Potentially Drives the Differentiation of Eating Behaviours via Alterations to the Gut Microbiome in Infants
Cathy Yan, Helen Zhao, Navika Nayar, Kyung E. Rhee, Julie C. Lumeng
bioRxiv 2021.04.24.438478; doi: https://doi.org/10.1101/2021.04.24.438478
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Diet Potentially Drives the Differentiation of Eating Behaviours via Alterations to the Gut Microbiome in Infants
Cathy Yan, Helen Zhao, Navika Nayar, Kyung E. Rhee, Julie C. Lumeng
bioRxiv 2021.04.24.438478; doi: https://doi.org/10.1101/2021.04.24.438478

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