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Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variant

Anne Weiss, Franck Touret, Cecile Baronti, Magali Gilles, Bruno Hoen, Antoine Nougairède, Xavier de Lamballerie, Morten Otto Alexander Sommer
doi: https://doi.org/10.1101/2021.04.26.441457
Anne Weiss
1UNION therapeutics Research Services, Tuborg Havnevej 18, 2900 Hellerup, Denmark
2Novo Nordisk Center for Biosustainability, Technical University Denmark, Kemitorvet 220, Kongens Lyngby, Denmark
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Franck Touret
3Unité des Virus Émergents (UVE: Aix-Marseille University -IRD 190-Inserm 1207-IHU Méditerranée, Infection), Marseille, France
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Cecile Baronti
3Unité des Virus Émergents (UVE: Aix-Marseille University -IRD 190-Inserm 1207-IHU Méditerranée, Infection), Marseille, France
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Magali Gilles
3Unité des Virus Émergents (UVE: Aix-Marseille University -IRD 190-Inserm 1207-IHU Méditerranée, Infection), Marseille, France
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Bruno Hoen
4Institute Pasteur, 25-28 rue du Docteur Roux, 75724 Paris Cedex 15, France
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Antoine Nougairède
3Unité des Virus Émergents (UVE: Aix-Marseille University -IRD 190-Inserm 1207-IHU Méditerranée, Infection), Marseille, France
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Xavier de Lamballerie
3Unité des Virus Émergents (UVE: Aix-Marseille University -IRD 190-Inserm 1207-IHU Méditerranée, Infection), Marseille, France
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  • For correspondence: xavier.de-lamballerie@univ-amu.fr
Morten Otto Alexander Sommer
2Novo Nordisk Center for Biosustainability, Technical University Denmark, Kemitorvet 220, Kongens Lyngby, Denmark
5UNION therapeutics, Tuborg Havnevej 18, 2900 Hellerup, Denmark
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Abstract

SARS-CoV-2 variants are emerging with potential increased transmissibility highlighting the great unmet medical need for new therapies. Niclosamide is a potent anti-SARS-CoV-2 agent that has advanced in clinical development. We validate the potent antiviral efficacy of niclosamide in a SARS-CoV-2 human airway model. Furthermore, niclosamide is effective against the D614G, B.1.1.7 and B.1.351 variants. Our data further support the potent anti-SARS-CoV-2 properties of niclosamide and highlights its great potential as a therapeutic agent for COVID-19.

Competing Interest Statement

AW and MOAS have shares or options in UNION therapeutics. All other authors have no competing interests to declare.

Footnotes

  • ↵* Shared last authorship: Xavier de Lamballerie (xavier.de-lamballerie{at}univ-amu.fr) and Morten Otto Alexander (morten.sommer{at}uniontherapeutics.com and msom{at}biosustain.dtu.dk)

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.
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Posted April 26, 2021.
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Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variant
Anne Weiss, Franck Touret, Cecile Baronti, Magali Gilles, Bruno Hoen, Antoine Nougairède, Xavier de Lamballerie, Morten Otto Alexander Sommer
bioRxiv 2021.04.26.441457; doi: https://doi.org/10.1101/2021.04.26.441457
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Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the UK B.1.1.7 and SA B.1.351 variant
Anne Weiss, Franck Touret, Cecile Baronti, Magali Gilles, Bruno Hoen, Antoine Nougairède, Xavier de Lamballerie, Morten Otto Alexander Sommer
bioRxiv 2021.04.26.441457; doi: https://doi.org/10.1101/2021.04.26.441457

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