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Olfactory receptor-dependent receptor repression in Drosophila

Kaan Mika, Steeve Cruchet, Phing Chian Chai, View ORCID ProfileLucia L. Prieto-Godino, View ORCID ProfileThomas O. Auer, Sylvain Pradervand, View ORCID ProfileRichard Benton
doi: https://doi.org/10.1101/2021.04.27.441568
Kaan Mika
1Center for Integrative Genomics, Faculty of Biology and Medicine University of Lausanne, CH-1015, Lausanne, Switzerland
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Steeve Cruchet
1Center for Integrative Genomics, Faculty of Biology and Medicine University of Lausanne, CH-1015, Lausanne, Switzerland
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Phing Chian Chai
1Center for Integrative Genomics, Faculty of Biology and Medicine University of Lausanne, CH-1015, Lausanne, Switzerland
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Lucia L. Prieto-Godino
1Center for Integrative Genomics, Faculty of Biology and Medicine University of Lausanne, CH-1015, Lausanne, Switzerland
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  • ORCID record for Lucia L. Prieto-Godino
Thomas O. Auer
1Center for Integrative Genomics, Faculty of Biology and Medicine University of Lausanne, CH-1015, Lausanne, Switzerland
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Sylvain Pradervand
1Center for Integrative Genomics, Faculty of Biology and Medicine University of Lausanne, CH-1015, Lausanne, Switzerland
2Genomic Technologies Facility, Faculty of Biology and Medicine, University of Lausanne, CH-1015, Lausanne, Switzerland
3Vital-IT Group, Swiss Institute of Bioinformatics, CH-1015 Lausanne, Switzerland
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Richard Benton
1Center for Integrative Genomics, Faculty of Biology and Medicine University of Lausanne, CH-1015, Lausanne, Switzerland
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  • ORCID record for Richard Benton
  • For correspondence: Richard.Benton@unil.ch
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Abstract

In olfactory systems across phyla, most sensory neurons transcribe a single olfactory receptor gene selected from a large genomic repertoire. We describe novel receptor gene-dependent mechanisms that ensure singular expression of receptors encoded by a tandem gene array in Drosophila. Transcription from upstream genes in the cluster runs through the coding region of downstream loci to inhibit their expression in cis, via transcriptional interference. Moreover, one receptor blocks expression of other receptor proteins in trans through a post-transcriptional mechanism. These repression mechanisms operate in endogenous neurons to ensure their unique expression. Our data provide evidence for inter-olfactory receptor regulation in invertebrates, and highlight unprecedented, but potentially widespread, mechanisms for ensuring exclusive expression of chemosensory receptors, and other protein families, encoded by tandemly-arranged genes.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted April 27, 2021.
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Olfactory receptor-dependent receptor repression in Drosophila
Kaan Mika, Steeve Cruchet, Phing Chian Chai, Lucia L. Prieto-Godino, Thomas O. Auer, Sylvain Pradervand, Richard Benton
bioRxiv 2021.04.27.441568; doi: https://doi.org/10.1101/2021.04.27.441568
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Olfactory receptor-dependent receptor repression in Drosophila
Kaan Mika, Steeve Cruchet, Phing Chian Chai, Lucia L. Prieto-Godino, Thomas O. Auer, Sylvain Pradervand, Richard Benton
bioRxiv 2021.04.27.441568; doi: https://doi.org/10.1101/2021.04.27.441568

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