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Genome-wide mutational signatures of immunological diversification in normal lymphocytes
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Francesco Maura, Daniel Leongamornlert, Mathijs A. Sanders, Alex Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Robert J. Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David Kent, Peter J Campbell
doi: https://doi.org/10.1101/2021.04.29.441939
Heather E Machado
1Wellcome Sanger Institute, Hinxton, United Kingdom
Emily Mitchell
1Wellcome Sanger Institute, Hinxton, United Kingdom
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
Nina F Øbro
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
4Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Kirsten Kübler
5Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
6Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA
7Harvard Medical School, Boston, Massachusetts, USA
Megan Davies
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
8Cambridge Molecular Diagnostics, Milton Road, Cambridge, United Kingdom
Francesco Maura
9Sylvester Comprehensive Cancer Center, Miami, Florida, USA
Daniel Leongamornlert
1Wellcome Sanger Institute, Hinxton, United Kingdom
Mathijs A. Sanders
1Wellcome Sanger Institute, Hinxton, United Kingdom
10Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands
Alex Cagan
1Wellcome Sanger Institute, Hinxton, United Kingdom
Craig McDonald
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
11York Biomedical Research Institute, University of York, Wentworth Way, York, United Kingdom
Miriam Belmonte
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
11York Biomedical Research Institute, University of York, Wentworth Way, York, United Kingdom
Mairi S. Shepherd
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
Robert J. Osborne
1Wellcome Sanger Institute, Hinxton, United Kingdom
12Biofidelity, 330 Cambridge Science Park, Milton Road, Cambridge, United Kingdom
Krishnaa Mahbubani
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
13Department of Surgery, University of Cambridge, Cambridge, United Kingdom
14NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom
Iñigo Martincorena
1Wellcome Sanger Institute, Hinxton, United Kingdom
Elisa Laurenti
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
Anthony R Green
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
Gad Getz
5Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
6Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA
7Harvard Medical School, Boston, Massachusetts, USA
15Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
Paz Polak
16Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, USA
Kourosh Saeb-Parsy
13Department of Surgery, University of Cambridge, Cambridge, United Kingdom
14NIHR Cambridge Biomedical Research Centre, Cambridge Biomedical Campus, Cambridge, United Kingdom
Daniel J Hodson
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
David Kent
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
3Department of Hematology, University of Cambridge, Cambridge, United Kingdom
11York Biomedical Research Institute, University of York, Wentworth Way, York, United Kingdom
Peter J Campbell
1Wellcome Sanger Institute, Hinxton, United Kingdom
2Wellcome MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom
Posted April 30, 2021.
Genome-wide mutational signatures of immunological diversification in normal lymphocytes
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Francesco Maura, Daniel Leongamornlert, Mathijs A. Sanders, Alex Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Robert J. Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David Kent, Peter J Campbell
bioRxiv 2021.04.29.441939; doi: https://doi.org/10.1101/2021.04.29.441939
Genome-wide mutational signatures of immunological diversification in normal lymphocytes
Heather E Machado, Emily Mitchell, Nina F Øbro, Kirsten Kübler, Megan Davies, Francesco Maura, Daniel Leongamornlert, Mathijs A. Sanders, Alex Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Robert J. Osborne, Krishnaa Mahbubani, Iñigo Martincorena, Elisa Laurenti, Anthony R Green, Gad Getz, Paz Polak, Kourosh Saeb-Parsy, Daniel J Hodson, David Kent, Peter J Campbell
bioRxiv 2021.04.29.441939; doi: https://doi.org/10.1101/2021.04.29.441939
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