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Pupil size dynamics predict dLGN firing mode over a wide range of timescales

View ORCID ProfileDavide Crombie, View ORCID ProfileMartin A. Spacek, View ORCID ProfileChristian Leibold, View ORCID ProfileLaura Busse
doi: https://doi.org/10.1101/2021.04.30.442134
Davide Crombie
1Division of Neurobiology, Department Biology II, LMU Munich, Munich, Germany
2Graduate School of Systemic Neurosciences, LMU Munich, Munich, Germany
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Martin A. Spacek
1Division of Neurobiology, Department Biology II, LMU Munich, Munich, Germany
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Christian Leibold
1Division of Neurobiology, Department Biology II, LMU Munich, Munich, Germany
3Bernstein Centre for Computational Neuroscience, Munich, Germany
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Laura Busse
1Division of Neurobiology, Department Biology II, LMU Munich, Munich, Germany
3Bernstein Centre for Computational Neuroscience, Munich, Germany
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Summary

Pupil size is a commonly used proxy for waking brain states such as arousal, and has been related to activity modulations in cortical sensory areas. Here, we asked whether the dorsolateral geniculate nucleus (dLGN), which provides sensory input to the visual cortex, is modulated by pupil-indexed arousal. Observing that the pupil size oscillates at multiple timescales, we developed a method to show that the spiking mode of the dLGN is predicted by pupil size oscillations over several of these timescales. Overall, we found that tonic spikes preferentially occurred during pupil dilation, while bursts occurred during contraction. These preferences could not be explained solely by pupil size per se or by the locomotion of the animal, and were also present during periods of stimulus viewing. We conclude that dLGN spiking activity is modulated by pupil-indexed arousal processes on various timescales, influencing the mode in which sensory signals are passed on to the cortex.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* Shared senior authors

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted April 30, 2021.
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Pupil size dynamics predict dLGN firing mode over a wide range of timescales
Davide Crombie, Martin A. Spacek, Christian Leibold, Laura Busse
bioRxiv 2021.04.30.442134; doi: https://doi.org/10.1101/2021.04.30.442134
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Pupil size dynamics predict dLGN firing mode over a wide range of timescales
Davide Crombie, Martin A. Spacek, Christian Leibold, Laura Busse
bioRxiv 2021.04.30.442134; doi: https://doi.org/10.1101/2021.04.30.442134

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