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SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection

View ORCID ProfileRayan Khaddaj-Mallat, Natija Aldib, Anne-Sophie Paquette, Aymeric Ferreira, Sarah Lecordier, Maxime Bernard, View ORCID ProfileArmen Saghatelyan, View ORCID ProfileAyman ElAli
doi: https://doi.org/10.1101/2021.04.30.442194
Rayan Khaddaj-Mallat
1Neuroscience Axis, Research Center of CHU de Québec - Université Laval, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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  • ORCID record for Rayan Khaddaj-Mallat
Natija Aldib
1Neuroscience Axis, Research Center of CHU de Québec - Université Laval, Quebec City, QC, Canada
2Research Center CERVO, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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Anne-Sophie Paquette
1Neuroscience Axis, Research Center of CHU de Québec - Université Laval, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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Aymeric Ferreira
2Research Center CERVO, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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Sarah Lecordier
1Neuroscience Axis, Research Center of CHU de Québec - Université Laval, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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Maxime Bernard
1Neuroscience Axis, Research Center of CHU de Québec - Université Laval, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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Armen Saghatelyan
2Research Center CERVO, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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  • ORCID record for Armen Saghatelyan
Ayman ElAli
1Neuroscience Axis, Research Center of CHU de Québec - Université Laval, Quebec City, QC, Canada
3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
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  • ORCID record for Ayman ElAli
  • For correspondence: ayman.el-ali@crchudequebec.ulaval.ca
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Article Information

doi 
https://doi.org/10.1101/2021.04.30.442194
History 
  • May 3, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.

Author Information

  1. Rayan Khaddaj-Mallat1,3,
  2. Natija Aldib1,2,3,
  3. Anne-Sophie Paquette1,3,
  4. Aymeric Ferreira2,3,
  5. Sarah Lecordier1,3,
  6. Maxime Bernard1,3,
  7. Armen Saghatelyan2,3 and
  8. Ayman ElAli1,3,*
  1. 1Neuroscience Axis, Research Center of CHU de Québec - Université Laval, Quebec City, QC, Canada
  2. 2Research Center CERVO, Quebec City, QC, Canada
  3. 3Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC, Canada
  1. ↵*Correspondence: Dr Ayman ElAli, Neuroscience Axis (T2-33), Research Center of CHU de Québec-Université Laval 2705 Laurier Boulevard, Quebec City, QC, G1V 4G2, Canada, E-mail: ayman.el-ali{at}crchudequebec.ulaval.ca
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Posted May 03, 2021.
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SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection
Rayan Khaddaj-Mallat, Natija Aldib, Anne-Sophie Paquette, Aymeric Ferreira, Sarah Lecordier, Maxime Bernard, Armen Saghatelyan, Ayman ElAli
bioRxiv 2021.04.30.442194; doi: https://doi.org/10.1101/2021.04.30.442194
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SARS-CoV-2 spike protein induces brain pericyte immunoreactivity in absence of productive viral infection
Rayan Khaddaj-Mallat, Natija Aldib, Anne-Sophie Paquette, Aymeric Ferreira, Sarah Lecordier, Maxime Bernard, Armen Saghatelyan, Ayman ElAli
bioRxiv 2021.04.30.442194; doi: https://doi.org/10.1101/2021.04.30.442194

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