New Results
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
View ORCID ProfileSokratis A. Apostolidis, Amrita Sarkar, View ORCID ProfileHeather M. Giannini, View ORCID ProfileRishi R. Goel, View ORCID ProfileDivij Mathew, Aae Suzuki, View ORCID ProfileAmy E. Baxter, View ORCID ProfileAllison R. Greenplate, View ORCID ProfileCécile Alanio, Mohamed Abdel-Hakeem, View ORCID ProfileDerek A. Oldridge, View ORCID ProfileJosephine Giles, Jennifer E. Wu, View ORCID ProfileZeyu Chen, Yinghui Jane Huang, View ORCID ProfileAjinkya Pattekar, View ORCID ProfileSasikanth Manne, View ORCID ProfileOliva Kuthuru, View ORCID ProfileJeanette Dougherty, Brittany Weiderhold, View ORCID ProfileAriel R. Weisman, Caroline A. G. Ittner, View ORCID ProfileSigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, View ORCID ProfileLaura A. Vella, The UPenn COVID Processing Unit, View ORCID ProfileJohn P. Reilly, Scott E. Hensley, Lubica Rauova, Liang Zhao, View ORCID ProfileNuala J. Meyer, View ORCID ProfileMortimer Poncz, Charles S. Abrams, View ORCID ProfileE. John Wherry
doi: https://doi.org/10.1101/2021.05.01.442279
Sokratis A. Apostolidis
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
2Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Amrita Sarkar
3Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Heather M. Giannini
5Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Rishi R. Goel
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Divij Mathew
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Aae Suzuki
6Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Amy E. Baxter
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Allison R. Greenplate
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
8Immune Health™, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Cécile Alanio
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
9Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Mohamed Abdel-Hakeem
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Derek A. Oldridge
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
10Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA
11Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Josephine Giles
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
9Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Jennifer E. Wu
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
9Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Zeyu Chen
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Yinghui Jane Huang
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Ajinkya Pattekar
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
8Immune Health™, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Sasikanth Manne
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Oliva Kuthuru
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Jeanette Dougherty
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Brittany Weiderhold
6Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Ariel R. Weisman
5Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Caroline A. G. Ittner
5Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Sigrid Gouma
12Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Debora Dunbar
13Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Ian Frank
13Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Alexander C. Huang
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
9Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
14Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Laura A. Vella
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
15Division of Infectious Diseases, Department of Pediatrics, Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
John P. Reilly
5Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Scott E. Hensley
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
12Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Lubica Rauova
3Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
4Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Liang Zhao
6Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Nuala J. Meyer
5Division of Pulmonary, Allergy and Critical Care Medicine, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Mortimer Poncz
3Division of Hematology, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
4Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Charles S. Abrams
6Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
E. John Wherry
1Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
7Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
8Immune Health™, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
9Parker Institute for Cancer Immunotherapy, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Posted May 03, 2021.
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Allison R. Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Derek A. Oldridge, Josephine Giles, Jennifer E. Wu, Zeyu Chen, Yinghui Jane Huang, Ajinkya Pattekar, Sasikanth Manne, Oliva Kuthuru, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Charles S. Abrams, E. John Wherry
bioRxiv 2021.05.01.442279; doi: https://doi.org/10.1101/2021.05.01.442279
Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19
Sokratis A. Apostolidis, Amrita Sarkar, Heather M. Giannini, Rishi R. Goel, Divij Mathew, Aae Suzuki, Amy E. Baxter, Allison R. Greenplate, Cécile Alanio, Mohamed Abdel-Hakeem, Derek A. Oldridge, Josephine Giles, Jennifer E. Wu, Zeyu Chen, Yinghui Jane Huang, Ajinkya Pattekar, Sasikanth Manne, Oliva Kuthuru, Jeanette Dougherty, Brittany Weiderhold, Ariel R. Weisman, Caroline A. G. Ittner, Sigrid Gouma, Debora Dunbar, Ian Frank, Alexander C. Huang, Laura A. Vella, The UPenn COVID Processing Unit, John P. Reilly, Scott E. Hensley, Lubica Rauova, Liang Zhao, Nuala J. Meyer, Mortimer Poncz, Charles S. Abrams, E. John Wherry
bioRxiv 2021.05.01.442279; doi: https://doi.org/10.1101/2021.05.01.442279
Subject Area
Subject Areas
- Biochemistry (11495)
- Bioengineering (8570)
- Bioinformatics (28733)
- Biophysics (14728)
- Cancer Biology (11852)
- Cell Biology (17061)
- Clinical Trials (138)
- Developmental Biology (9275)
- Ecology (13967)
- Epidemiology (2067)
- Evolutionary Biology (18069)
- Genetics (12108)
- Genomics (16555)
- Immunology (11656)
- Microbiology (27535)
- Molecular Biology (11325)
- Neuroscience (59853)
- Paleontology (446)
- Pathology (1839)
- Pharmacology and Toxicology (3169)
- Physiology (4854)
- Plant Biology (10223)
- Synthetic Biology (2827)
- Systems Biology (7271)
- Zoology (1607)