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Muscle fatigue revisited - Insights from optically pumped magnetometers

Davide Sometti, Lorenzo Semeia, Hui Chen, Juergen Dax, Cornelius Kronlage, Sangyeob Baek, Milena Kirchgässner, Alyssa Romano, Johanna Heilos, Deborah Staber, Julia Oppold, Giulia Righetti, Thomas Middelmann, Christoph Braun, Philip Broser, View ORCID ProfileJustus Marquetand
doi: https://doi.org/10.1101/2021.05.03.442396
Davide Sometti
2Department of Neural Dynamics and Magnetoencephalography, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
3MEG-Center, University of Tübingen, Tübingen, Germany
6Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tübingen, 72074 Tübingen, Germany
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Lorenzo Semeia
5IDM/fMEG Center of the Helmholtz Center Munich at the University of Tübingen, University of Tübingen, German Center for Diabetes Research (DZD), Tübingen, Germany
6Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tübingen, 72074 Tübingen, Germany
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Hui Chen
2Department of Neural Dynamics and Magnetoencephalography, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
3MEG-Center, University of Tübingen, Tübingen, Germany
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Juergen Dax
2Department of Neural Dynamics and Magnetoencephalography, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
3MEG-Center, University of Tübingen, Tübingen, Germany
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Cornelius Kronlage
1Department of Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Sangyeob Baek
2Department of Neural Dynamics and Magnetoencephalography, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
3MEG-Center, University of Tübingen, Tübingen, Germany
6Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tübingen, 72074 Tübingen, Germany
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Milena Kirchgässner
1Department of Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Alyssa Romano
1Department of Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Johanna Heilos
1Department of Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Deborah Staber
1Department of Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Julia Oppold
1Department of Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
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Giulia Righetti
2Department of Neural Dynamics and Magnetoencephalography, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
3MEG-Center, University of Tübingen, Tübingen, Germany
4Center for Ophthalmology, University of Tübingen, Tübingen, Germany
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Thomas Middelmann
5IDM/fMEG Center of the Helmholtz Center Munich at the University of Tübingen, University of Tübingen, German Center for Diabetes Research (DZD), Tübingen, Germany
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Christoph Braun
2Department of Neural Dynamics and Magnetoencephalography, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
3MEG-Center, University of Tübingen, Tübingen, Germany
6Graduate Training Centre of Neuroscience, International Max Planck Research School, University of Tübingen, 72074 Tübingen, Germany
7Department of Biosignals, Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany
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Philip Broser
8CIMeC, Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy
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Justus Marquetand
1Department of Epileptology, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
2Department of Neural Dynamics and Magnetoencephalography, Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany
3MEG-Center, University of Tübingen, Tübingen, Germany
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  • ORCID record for Justus Marquetand
  • For correspondence: Justus.marquetand@med.uni-tuebingen.de
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Abstract

Muscle fatigue is well characterized electromyographically, nevertheless only information about summed potential differences is detectable. In contrast, recently developed quantum sensors optically pumped magnetometers (OPMs) offer the advantage of recording both the electrical current propagation in the muscle as well as its geometry, by measuring the magnetic field generated by the muscular action potentials. Magnetomyographic investigation of muscle fatigue is still lacking and it is an open question whether fatigue is characterized similarly in magnetomyography (MMG) compared to electromyography (EMG). Herein, we investigated the muscle fatigue during a 3×1-min strong isometric contraction of the rectus femoris muscle of 12 healthy subjects using simultaneous EMG-MMG (4-channel surface EMG and 4 OPM along the rectus femoris muscle).

Both EMG and MMG showed the characteristic frequency decrease in the signal magnitude during isometric contraction, which is typical for muscle fatigue. In addition, it was shown that the main part of this frequency decrease seems to occur in the circular component of the magnetic field around the muscle fibers and less longitudinally along the muscle fibers. Overall, these results show not only that magnetomyography is capable of reproducing the electromyographic standards in identifying muscular fatigue, but it also adds relevant information about the spatial characterization of the signal. Therefore, OPM-MMG offers new insights for the study of muscular activity and might serve as a new, supplementary neurophysiological method.

Competing Interest Statement

The authors have declared no competing interest.

  • Abbreviations
    OPM
    optically pumped magnetometer
    EMG
    electromyography
    sEMG
    surface electromyography
    MMG
    magnetomyography
    OPM-MMG
    optically pumped magnetometer magnetomyography
    MEG
    Magnetoencephalography
    SQUID
    superconducting quantum interference device
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    Posted May 03, 2021.
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    Muscle fatigue revisited - Insights from optically pumped magnetometers
    Davide Sometti, Lorenzo Semeia, Hui Chen, Juergen Dax, Cornelius Kronlage, Sangyeob Baek, Milena Kirchgässner, Alyssa Romano, Johanna Heilos, Deborah Staber, Julia Oppold, Giulia Righetti, Thomas Middelmann, Christoph Braun, Philip Broser, Justus Marquetand
    bioRxiv 2021.05.03.442396; doi: https://doi.org/10.1101/2021.05.03.442396
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    Muscle fatigue revisited - Insights from optically pumped magnetometers
    Davide Sometti, Lorenzo Semeia, Hui Chen, Juergen Dax, Cornelius Kronlage, Sangyeob Baek, Milena Kirchgässner, Alyssa Romano, Johanna Heilos, Deborah Staber, Julia Oppold, Giulia Righetti, Thomas Middelmann, Christoph Braun, Philip Broser, Justus Marquetand
    bioRxiv 2021.05.03.442396; doi: https://doi.org/10.1101/2021.05.03.442396

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