Abstract
Conventional environmental health studies primarily focus on limited environmental stressors at the population level, which lacks the power of dissecting the complexity and heterogeneity of individualized environmental exposures. Here we integrated deep-profiled longitudinal personal exposome and internal multi-omics to systematically investigate how the exposome shapes an individual’s phenome. We annotated thousands of chemical and biological components in the personal exposome cloud and found thousands of internal biomolecules were significantly correlated with the external exposome, which was further cross validated using corresponding clinical data. In particular, our results showed that agrochemicals and fungi predominated in the highly diverse and dynamic personal exposome, and the biomolecules and pathways related to the individual’s immune system, kidneys, and liver were highly correlated with the personal external exposome. Overall, our findings demonstrate dynamic interactions between the personal exposome and internal multi-omics and provide insights into the impact of the environmental exposome on precision health.
Competing Interest Statement
The authors have declared no competing interest.
