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Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

View ORCID ProfileDavid Hocker, View ORCID ProfileCarlos D. Brody, View ORCID ProfileCristina Savin, View ORCID ProfileChristine M Constantinople
doi: https://doi.org/10.1101/2021.05.06.442972
David Hocker
1Center for Neural Science, New York University, New York, NY 10003, USA
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  • For correspondence: dh148@nyu.edu
Carlos D. Brody
2Princeton Neuroscience Institute, Princeton University, Princeton, NJ, 08544, USA
3Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA
4Howard Hughes Medical Institute, Princeton University, Princeton, NJ, 08544, USA
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Cristina Savin
1Center for Neural Science, New York University, New York, NY 10003, USA
5Center for Data Science, New York University, New York, NY 10011, USA
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Christine M Constantinople
1Center for Neural Science, New York University, New York, NY 10003, USA
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1 Abstract

Studies of neural dynamics in lateral orbitofrontal cortex (lOFC) have shown that subsets of neurons that encode distinct aspects of behavior, such as value, may project to common downstream targets. However, it is unclear whether reward history, which may subserve lOFC’s well-documented role in learning, is represented by functional subpopulations in lOFC. We analyzed neural recordings from rats performing a value-based decision-making task, in which we previously documented trial-by-trial learning that required lOFC. We found five distinct clusters of lOFC neurons, either based on clustering of their trial-averaged peristimulus time histograms (PSTHs), or a feature space defined by their average conditional firing rates aligned to different task variables. We observed weak encoding of reward attributes, but stronger encoding of reward history, the animal’s left or right choice, and reward receipt across all clusters. Only one cluster, however, encoded the animal’s reward history at the time shortly preceding the choice, suggesting a possible role in integrating previous and current trial outcomes at the time of choice.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵† Co-senior authors

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 07, 2021.
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Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
David Hocker, Carlos D. Brody, Cristina Savin, Christine M Constantinople
bioRxiv 2021.05.06.442972; doi: https://doi.org/10.1101/2021.05.06.442972
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Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
David Hocker, Carlos D. Brody, Cristina Savin, Christine M Constantinople
bioRxiv 2021.05.06.442972; doi: https://doi.org/10.1101/2021.05.06.442972

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