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Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex

Atena Akbari, Saskia Bollmann, Tonima S Ali, Markus Barth
doi: https://doi.org/10.1101/2021.05.07.443052
Atena Akbari
1Centre for Advanced Imaging, University of Queensland, Brisbane, Australia
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Saskia Bollmann
1Centre for Advanced Imaging, University of Queensland, Brisbane, Australia
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Tonima S Ali
2School of Biomedical Engineering, The University of Sydney, Sydney, Australia
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Markus Barth
1Centre for Advanced Imaging, University of Queensland, Brisbane, Australia
3ARC Training Centre for Innovation in Biomedical Imaging Technology, The University of Queensland, Brisbane, Australia
4School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Queensland, Australia
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Abstract

Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast is a common method for studying human brain function non-invasively. Gradient-echo (GRE) BOLD is highly sensitive to the blood oxygenation change in blood vessels; however, the signal specificity can be degraded due to signal leakage from the activated lower layers to the superficial layers in depth-dependent (also called laminar or layer-specific) fMRI. Alternatively, physiological variables such as cerebral blood volume using VAscular-Space-Occupancy (VASO) measurements have shown higher spatial specificity compared to BOLD. To better understand the physiological mechanisms (e.g., blood volume and oxygenation change) and to interpret the measured depth-dependent responses we need models that reflect vascular properties at this scale. For this purpose, we adapted a “cortical vascular model” previously developed to predict the layer-specific BOLD signal change in human primary visual cortex to also predict layer-specific VASO response. To evaluate the model, we compared the predictions with experimental results of simultaneous VASO and BOLD measurements in a group of healthy participants. Fitting the model to our experimental findings provided an estimate of CBV change in different vascular compartments upon neural activity. We found that stimulus-evoked CBV changes mainly occur in intracortical arteries as well as small arterioles and capillaries and that the contribution from venules is small for a long stimulus (~30 sec). Our results confirm the notion that VASO contrast is less susceptible to large vessel effects compared to BOLD.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted May 08, 2021.
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Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex
Atena Akbari, Saskia Bollmann, Tonima S Ali, Markus Barth
bioRxiv 2021.05.07.443052; doi: https://doi.org/10.1101/2021.05.07.443052
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Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex
Atena Akbari, Saskia Bollmann, Tonima S Ali, Markus Barth
bioRxiv 2021.05.07.443052; doi: https://doi.org/10.1101/2021.05.07.443052

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