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Heterogeneity in viral infections increases the rate of deleterious mutation accumulation

View ORCID ProfileBrent Allman, Katia Koelle, View ORCID ProfileDaniel Weissman
doi: https://doi.org/10.1101/2021.05.07.443113
Brent Allman
*Graduate Program in Population Biology, Ecology, and Evolution, Emory University, Atlanta, Georgia 30322
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  • For correspondence: brent.elliott.allman@emory.edu
Katia Koelle
†Department of Biology, Emory University, Atlanta, Georgia 30322
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Daniel Weissman
†Department of Biology, Emory University, Atlanta, Georgia 30322
‡Department of Physics, Emory University, Atlanta, Georgia 30322
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1 Abstract

RNA viruses have high mutation rates, with the majority of mutations being deleterious. We examine patterns of deleterious mutation accumulation over multiple rounds of viral replication, with a focus on how cellular coinfection and heterogeneity in viral output affect these patterns. Specifically, using agentbased intercellular simulations we find, in agreement with previous studies, that coinfection of cells by viruses relaxes the strength of purifying selection, and thereby increases the rate of deleterious mutation accumulation. We further find that cellular heterogeneity in viral output exacerbates the rate of deleterious mutation accumulation, regardless of whether this heterogeneity in viral output is stochastic or is due to variation in cellular multiplicity of infection. These results highlight the need to consider the unique life histories of viruses and their population structure to better understand observed patterns of viral evolution.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
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Posted May 08, 2021.
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Heterogeneity in viral infections increases the rate of deleterious mutation accumulation
Brent Allman, Katia Koelle, Daniel Weissman
bioRxiv 2021.05.07.443113; doi: https://doi.org/10.1101/2021.05.07.443113
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Heterogeneity in viral infections increases the rate of deleterious mutation accumulation
Brent Allman, Katia Koelle, Daniel Weissman
bioRxiv 2021.05.07.443113; doi: https://doi.org/10.1101/2021.05.07.443113

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