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The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex
View ORCID ProfileRoger Vargas Jr, Luca Freschi, Andrea Spitaleri, Sabira Tahseen, Ivan Barilar, Stefan Niemann, Paolo Miotto, Daniella Maria Cirillo, Claudio U. Köser, View ORCID ProfileMaha R. Farhat
doi: https://doi.org/10.1101/2021.05.07.443178
Roger Vargas Jr
1Department of Systems Biology, Harvard Medical School, Boston, USA
2Department of Biomedical Informatics, Harvard Medical School, Boston, USA
Luca Freschi
2Department of Biomedical Informatics, Harvard Medical School, Boston, USA
Andrea Spitaleri
3Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
Sabira Tahseen
4National TB Reference laboratory, National TB Control Program, Islamabad, Pakistan
Ivan Barilar
5German Center for Infection Research, Partner site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
6Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany
Stefan Niemann
5German Center for Infection Research, Partner site Hamburg-Lübeck-Borstel-Riems, Borstel, Germany
6Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany
Paolo Miotto
3Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
Daniella Maria Cirillo
3Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy
Claudio U. Köser
7Department of Genetics, University of Cambridge, Cambridge, UK
Maha R. Farhat
2Department of Biomedical Informatics, Harvard Medical School, Boston, USA
8Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, USA
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Posted May 08, 2021.
The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex
Roger Vargas Jr, Luca Freschi, Andrea Spitaleri, Sabira Tahseen, Ivan Barilar, Stefan Niemann, Paolo Miotto, Daniella Maria Cirillo, Claudio U. Köser, Maha R. Farhat
bioRxiv 2021.05.07.443178; doi: https://doi.org/10.1101/2021.05.07.443178
The role of epistasis in amikacin, kanamycin, bedaquiline, and clofazimine resistance in Mycobacterium tuberculosis complex
Roger Vargas Jr, Luca Freschi, Andrea Spitaleri, Sabira Tahseen, Ivan Barilar, Stefan Niemann, Paolo Miotto, Daniella Maria Cirillo, Claudio U. Köser, Maha R. Farhat
bioRxiv 2021.05.07.443178; doi: https://doi.org/10.1101/2021.05.07.443178
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