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Minimal functional alignment of ventromedial prefrontal cortex intracranial EEG signals during naturalistic viewing

View ORCID ProfileTiankang Xie, View ORCID ProfileJin Hyun Cheong, View ORCID ProfileJeremy R. Manning, Amanda M. Brandt, Joshua P. Aronson, Barbara C. Jobst, View ORCID ProfileKrzysztof A. Bujarski, View ORCID ProfileLuke J. Chang
doi: https://doi.org/10.1101/2021.05.10.443308
Tiankang Xie
1Dartmouth College, Hanover, NH 03755
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Jin Hyun Cheong
1Dartmouth College, Hanover, NH 03755
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Jeremy R. Manning
1Dartmouth College, Hanover, NH 03755
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Amanda M. Brandt
1Dartmouth College, Hanover, NH 03755
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Joshua P. Aronson
2Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756
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Barbara C. Jobst
2Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756
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Krzysztof A. Bujarski
2Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756
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  • ORCID record for Krzysztof A. Bujarski
Luke J. Chang
1Dartmouth College, Hanover, NH 03755
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  • For correspondence: luke.j.chang@dartmouth.edu
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Abstract

The ventromedial prefrontal cortex (vmPFC) has been thought to play an important role in processing endogenous information such as generating subjective affective meaning. Unlike sensory cortex, which processes exogenous information about the external world similarly across individuals, prior work has posited that vmPFC activity may be idiosyncratic to each individual, even when exposed to the same external stimulus. In this study, we recorded local field potentials (LFPs) from intracranial stereo electrodes implanted in patients with intractable epilepsy while they watched an emotionally engaging television show episode and evaluated temporal synchronization of these signals across participants in auditory cortex and vmPFC. Overall, we observed markedly lower intersubject synchronization of signals recorded from electrodes implanted in vmPFC compared to auditory cortex. A subset of patients, however, appeared to share similar vmPFC states during the more emotionally salient scenes. This work suggests that the vmPFC is involved in processing affective responses to ongoing experience in a state-like manner, but the specific states and temporal sequences are idiosyncratic to each individual, even when viewing the same television episode.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 10, 2021.
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Minimal functional alignment of ventromedial prefrontal cortex intracranial EEG signals during naturalistic viewing
Tiankang Xie, Jin Hyun Cheong, Jeremy R. Manning, Amanda M. Brandt, Joshua P. Aronson, Barbara C. Jobst, Krzysztof A. Bujarski, Luke J. Chang
bioRxiv 2021.05.10.443308; doi: https://doi.org/10.1101/2021.05.10.443308
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Minimal functional alignment of ventromedial prefrontal cortex intracranial EEG signals during naturalistic viewing
Tiankang Xie, Jin Hyun Cheong, Jeremy R. Manning, Amanda M. Brandt, Joshua P. Aronson, Barbara C. Jobst, Krzysztof A. Bujarski, Luke J. Chang
bioRxiv 2021.05.10.443308; doi: https://doi.org/10.1101/2021.05.10.443308

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