New Results
Expansion of mutation-driven haematopoietic clones is associated with insulin resistance and low HDL-cholesterol in individuals with obesity
View ORCID ProfileRosanne C. van Deuren, View ORCID ProfileJohanna C. Andersson-Assarsson, Felipe M. Kristensson, Marloes Steehouwer, View ORCID ProfileKajsa Sjöholm, View ORCID ProfilePer-Arne Svensson, View ORCID ProfileMarc Pieterse, View ORCID ProfileChristian Gilissen, View ORCID ProfileMagdalena Taube, View ORCID ProfilePeter Jacobson, View ORCID ProfileRosie Perkins, View ORCID ProfileHan G. Brunner, View ORCID ProfileMihai G. Netea, View ORCID ProfileMarkku Peltonen, View ORCID ProfileBjörn Carlsson, View ORCID ProfileAlexander Hoischen, View ORCID ProfileLena M.S. Carlsson
doi: https://doi.org/10.1101/2021.05.12.443095
Rosanne C. van Deuren
1Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
2Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
3Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
4Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands
Johanna C. Andersson-Assarsson
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Felipe M. Kristensson
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
6Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden
Marloes Steehouwer
1Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
3Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
Kajsa Sjöholm
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Per-Arne Svensson
7Institute of Health and Care Sciences, the Sahlgrenska Academy at University of Gothenburg; Gothenburg, Sweden
Marc Pieterse
1Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
Christian Gilissen
1Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
3Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
Magdalena Taube
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Peter Jacobson
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Rosie Perkins
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Han G. Brunner
1Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
8Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands
9Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands
10GROW School of Oncology and Developmental Biology, and MHeNs School of Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands
Mihai G. Netea
2Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
3Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
4Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands
11Department of Immunology and Metabolism, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany
Markku Peltonen
12Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
13Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
Björn Carlsson
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
14Early Clinical Development, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden
Alexander Hoischen
1Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands
2Department of Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands
3Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands
4Radboud Expertise Center for Immunodeficiency and Autoinflammation and Radboud Center for Infectious Disease (RCI), Radboud University Medical Center, Nijmegen, the Netherlands
Lena M.S. Carlsson
5Institute of Medicine, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
Posted July 09, 2021.
Expansion of mutation-driven haematopoietic clones is associated with insulin resistance and low HDL-cholesterol in individuals with obesity
Rosanne C. van Deuren, Johanna C. Andersson-Assarsson, Felipe M. Kristensson, Marloes Steehouwer, Kajsa Sjöholm, Per-Arne Svensson, Marc Pieterse, Christian Gilissen, Magdalena Taube, Peter Jacobson, Rosie Perkins, Han G. Brunner, Mihai G. Netea, Markku Peltonen, Björn Carlsson, Alexander Hoischen, Lena M.S. Carlsson
bioRxiv 2021.05.12.443095; doi: https://doi.org/10.1101/2021.05.12.443095
Expansion of mutation-driven haematopoietic clones is associated with insulin resistance and low HDL-cholesterol in individuals with obesity
Rosanne C. van Deuren, Johanna C. Andersson-Assarsson, Felipe M. Kristensson, Marloes Steehouwer, Kajsa Sjöholm, Per-Arne Svensson, Marc Pieterse, Christian Gilissen, Magdalena Taube, Peter Jacobson, Rosie Perkins, Han G. Brunner, Mihai G. Netea, Markku Peltonen, Björn Carlsson, Alexander Hoischen, Lena M.S. Carlsson
bioRxiv 2021.05.12.443095; doi: https://doi.org/10.1101/2021.05.12.443095
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