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Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants

Amarendra Pegu, Sarah O’Connell, Stephen D Schmidt, Sijy O’Dell, Chloe A. Talana, Lilin Lai, Jim Albert, View ORCID ProfileEvan Anderson, Hamilton Bennett, Kizzmekia S. Corbett, Britta Flach, Lisa Jackson, Brett Leav, Julie E. Ledgerwood, Catherine J. Luke, Mat Makowski, Paul C. Roberts, Mario Roederer, Paulina A. Rebolledo, Christina A. Rostad, Nadine G. Rouphael, Wei Shi, Lingshu Wang, Alicia T. Widge, Eun Sung Yang, the mRNA-1273 Study Group, John H. Beigel, View ORCID ProfileBarney S. Graham, John R Mascola, View ORCID ProfileMehul S. Suthar, Adrian McDermott, Nicole A. Doria-Rose
doi: https://doi.org/10.1101/2021.05.13.444010
Amarendra Pegu
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Sarah O’Connell
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Stephen D Schmidt
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Sijy O’Dell
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Chloe A. Talana
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Lilin Lai
2Department of Medicine, Center for Childhood Infections and Vaccines (CCIV) of Children’s Healthcare of Atlanta, Emory Vaccine Center, and Emory University Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA
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Jim Albert
3Emmes Company; Rockville, MD, USA
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Evan Anderson
2Department of Medicine, Center for Childhood Infections and Vaccines (CCIV) of Children’s Healthcare of Atlanta, Emory Vaccine Center, and Emory University Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA
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  • ORCID record for Evan Anderson
Hamilton Bennett
4Moderna, Inc.; Cambridge, MA, USA
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Kizzmekia S. Corbett
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Britta Flach
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Lisa Jackson
6Kaiser Permanente Washington Health Research Institute; Seattle, WA, USA
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Brett Leav
4Moderna, Inc.; Cambridge, MA, USA
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Julie E. Ledgerwood
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Catherine J. Luke
5Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA
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Mat Makowski
3Emmes Company; Rockville, MD, USA
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Paul C. Roberts
5Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA
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Mario Roederer
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Paulina A. Rebolledo
7Hope Clinic, Department of Medicine, Emory University School of Medicine; Decatur, GA, USA
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Christina A. Rostad
2Department of Medicine, Center for Childhood Infections and Vaccines (CCIV) of Children’s Healthcare of Atlanta, Emory Vaccine Center, and Emory University Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA
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Nadine G. Rouphael
7Hope Clinic, Department of Medicine, Emory University School of Medicine; Decatur, GA, USA
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Wei Shi
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Lingshu Wang
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Alicia T. Widge
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Eun Sung Yang
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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John H. Beigel
5Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, MD, USA
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Barney S. Graham
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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John R Mascola
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Mehul S. Suthar
2Department of Medicine, Center for Childhood Infections and Vaccines (CCIV) of Children’s Healthcare of Atlanta, Emory Vaccine Center, and Emory University Department of Pediatrics, Emory University School of Medicine; Atlanta, GA, USA
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Adrian McDermott
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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Nicole A. Doria-Rose
1Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda MD, USA
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  • For correspondence: nicole.doriarose@nih.gov
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Abstract

SARS-CoV-2 mutations may diminish vaccine-induced protective immune responses, and the durability of such responses has not been previously reported. Here, we present a comprehensive assessment of the impact of variants B.1.1.7, B.1.351, P.1, B.1.429, and B.1.526 on binding, neutralizing, and ACE2-blocking antibodies elicited by the vaccine mRNA-1273 over seven months. Cross-reactive neutralizing responses were rare after a single dose of mRNA-1273. At the peak of response to the second dose, all subjects had robust responses to all variants. Binding and functional antibodies against variants persisted in most subjects, albeit at low levels, for 6 months after the primary series of mRNA-1273. Across all assays, B.1.351 had the greatest impact on antibody recognition, and B.1.1.7 the least. These data complement ongoing studies of clinical protection to inform the potential need for additional boost vaccinations.

One-Sentence Summary Most mRNA-1273 vaccinated individuals maintained binding and functional antibodies against SARS-CoV-2 variants for 6 months.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. This article is a US Government work. It is not subject to copyright under 17 USC 105 and is also made available for use under a CC0 license.
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Posted May 16, 2021.
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Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants
Amarendra Pegu, Sarah O’Connell, Stephen D Schmidt, Sijy O’Dell, Chloe A. Talana, Lilin Lai, Jim Albert, Evan Anderson, Hamilton Bennett, Kizzmekia S. Corbett, Britta Flach, Lisa Jackson, Brett Leav, Julie E. Ledgerwood, Catherine J. Luke, Mat Makowski, Paul C. Roberts, Mario Roederer, Paulina A. Rebolledo, Christina A. Rostad, Nadine G. Rouphael, Wei Shi, Lingshu Wang, Alicia T. Widge, Eun Sung Yang, the mRNA-1273 Study Group, John H. Beigel, Barney S. Graham, John R Mascola, Mehul S. Suthar, Adrian McDermott, Nicole A. Doria-Rose
bioRxiv 2021.05.13.444010; doi: https://doi.org/10.1101/2021.05.13.444010
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Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants
Amarendra Pegu, Sarah O’Connell, Stephen D Schmidt, Sijy O’Dell, Chloe A. Talana, Lilin Lai, Jim Albert, Evan Anderson, Hamilton Bennett, Kizzmekia S. Corbett, Britta Flach, Lisa Jackson, Brett Leav, Julie E. Ledgerwood, Catherine J. Luke, Mat Makowski, Paul C. Roberts, Mario Roederer, Paulina A. Rebolledo, Christina A. Rostad, Nadine G. Rouphael, Wei Shi, Lingshu Wang, Alicia T. Widge, Eun Sung Yang, the mRNA-1273 Study Group, John H. Beigel, Barney S. Graham, John R Mascola, Mehul S. Suthar, Adrian McDermott, Nicole A. Doria-Rose
bioRxiv 2021.05.13.444010; doi: https://doi.org/10.1101/2021.05.13.444010

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