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Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression
View ORCID ProfileNida Meednu, View ORCID ProfileJavier Rangel-Moreno, View ORCID ProfileFan Zhang, Katherine Escalera-Rivera, Elisa Corsiero, Edoardo Prediletto, Edward DiCarlo, Susan Goodman, Laura T Donlin, View ORCID ProfileSoumya Raychauduri, Michele Bombardieri, Costantino Pitzalis, Dana E Orange, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Andrew McDavid, View ORCID ProfileJennifer H Anolik
doi: https://doi.org/10.1101/2021.05.14.443150
Nida Meednu
1Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Javier Rangel-Moreno
1Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Fan Zhang
2Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
5Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
6Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Boston, MA, USA
Katherine Escalera-Rivera
1Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
Elisa Corsiero
7Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, London, UK
Edoardo Prediletto
7Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, London, UK
Edward DiCarlo
8Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA
Susan Goodman
8Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA
Laura T Donlin
8Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA
Soumya Raychauduri
2Center for Data Sciences, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
3Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA
4Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA
5Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA
6Division of Rheumatology, Inflammation, and Immunity, Brigham and Women’s Hospital, Boston, MA, USA
9Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
Michele Bombardieri
7Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, London, UK
Costantino Pitzalis
7Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Queen Mary University of London, EC1M 6BQ, London, UK
Dana E Orange
8Division of Rheumatology, Hospital for Special Surgery, New York, NY 10021, USA
10Rockefeller University, New York, NY, USA
Andrew McDavid
1Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
13Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA
Jennifer H Anolik
1Division of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
11Department of Pathology, University of Rochester Medical Center, Rochester, NY, USA
12Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA
Article usage
Posted May 16, 2021.
Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression
Nida Meednu, Javier Rangel-Moreno, Fan Zhang, Katherine Escalera-Rivera, Elisa Corsiero, Edoardo Prediletto, Edward DiCarlo, Susan Goodman, Laura T Donlin, Soumya Raychauduri, Michele Bombardieri, Costantino Pitzalis, Dana E Orange, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Andrew McDavid, Jennifer H Anolik
bioRxiv 2021.05.14.443150; doi: https://doi.org/10.1101/2021.05.14.443150
Single cell analysis of RA synovial B cells reveals a dynamic spectrum of ectopic lymphoid B cell activation and hypermutation characterized by NR4A nuclear receptor expression
Nida Meednu, Javier Rangel-Moreno, Fan Zhang, Katherine Escalera-Rivera, Elisa Corsiero, Edoardo Prediletto, Edward DiCarlo, Susan Goodman, Laura T Donlin, Soumya Raychauduri, Michele Bombardieri, Costantino Pitzalis, Dana E Orange, Accelerating Medicines Partnership Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Andrew McDavid, Jennifer H Anolik
bioRxiv 2021.05.14.443150; doi: https://doi.org/10.1101/2021.05.14.443150
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