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The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A Ashley, Frank Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, Mehul Dhorda, Nguyen Hoang Chau, Nhien Nguyen Thanh Thuy, Paul N Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J Peto, Olivo Miotto, Lorenz von Seidlein, Tran Tinh Hien, Hagai Ginsburg, Nicholas PJ Day, Nicholas J. White, Arjen M Dondorp, Zbynek Bozdech
doi: https://doi.org/10.1101/2021.05.17.444396
Lei Zhu
1School of Biological Sciences, Nanyang Technological University, Singapore
Rob W. van der Pluijm
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
4Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Michal Kucharski
1School of Biological Sciences, Nanyang Technological University, Singapore
Sourav Nayak
1School of Biological Sciences, Nanyang Technological University, Singapore
Jaishree Tripathi
1School of Biological Sciences, Nanyang Technological University, Singapore
François Nosten
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
7Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand
Abul Faiz
8Ramu Upazila Health Complex, Cox’s Bazar, Bangladesh
9Malaria Research Group and Dev Care Foundation, Dhaka, Bangladesh
Chanaki Amaratunga
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
10Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA
Dysoley Lek
11National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
Elizabeth A Ashley
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
12Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos PDR
Frank Smithuis
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
13Myanmar Oxford Clinical Research Unit, Yangon, Myanmar
Aung Pyae Phyo
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
13Myanmar Oxford Clinical Research Unit, Yangon, Myanmar
Khin Lin
14Department of Medical Research, Pyin Oo Lwin, Myanmar
Mallika Imwong
8Ramu Upazila Health Complex, Cox’s Bazar, Bangladesh
15Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Mayfong Mayxay
12Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos PDR
16Institute of Research and Education Development (IRED), University of Health Sciences, Ministry of Health, Vientiane, Laos
Mehul Dhorda
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
17WorldWide Antimalarial Resistance Network – Asia-Pacific Regional Centre, Bangkok, Thailand
Nguyen Hoang Chau
18Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Nhien Nguyen Thanh Thuy
18Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Paul N Newton
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
12Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Vientiane, Laos PDR
Podjanee Jittamala
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
19Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Rupam Tripura
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Sasithon Pukrittayakamee
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
13Myanmar Oxford Clinical Research Unit, Yangon, Myanmar
20The Royal Society of Thailand, Dusit, Bangkok, Thailand
Thomas J Peto
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Olivo Miotto
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Lorenz von Seidlein
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Tran Tinh Hien
18Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
Hagai Ginsburg
21The Alexander Silberman Institute of Life Science, Hebrew University of Jerusalem, Israel
Nicholas PJ Day
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Nicholas J. White
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Arjen M Dondorp
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
3Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
Zbynek Bozdech
1School of Biological Sciences, Nanyang Technological University, Singapore
2Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Article usage
Posted May 17, 2021.
The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A Ashley, Frank Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, Mehul Dhorda, Nguyen Hoang Chau, Nhien Nguyen Thanh Thuy, Paul N Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J Peto, Olivo Miotto, Lorenz von Seidlein, Tran Tinh Hien, Hagai Ginsburg, Nicholas PJ Day, Nicholas J. White, Arjen M Dondorp, Zbynek Bozdech
bioRxiv 2021.05.17.444396; doi: https://doi.org/10.1101/2021.05.17.444396
The mechanism of artemisinin resistance of Plasmodium falciparum malaria parasites originates in their initial transcriptional response
Lei Zhu, Rob W. van der Pluijm, Michal Kucharski, Sourav Nayak, Jaishree Tripathi, François Nosten, Abul Faiz, Chanaki Amaratunga, Dysoley Lek, Elizabeth A Ashley, Frank Smithuis, Aung Pyae Phyo, Khin Lin, Mallika Imwong, Mayfong Mayxay, Mehul Dhorda, Nguyen Hoang Chau, Nhien Nguyen Thanh Thuy, Paul N Newton, Podjanee Jittamala, Rupam Tripura, Sasithon Pukrittayakamee, Thomas J Peto, Olivo Miotto, Lorenz von Seidlein, Tran Tinh Hien, Hagai Ginsburg, Nicholas PJ Day, Nicholas J. White, Arjen M Dondorp, Zbynek Bozdech
bioRxiv 2021.05.17.444396; doi: https://doi.org/10.1101/2021.05.17.444396
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