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Cochlear nucleus small cells use olivocochlear collaterals to encode sounds in noise

Adam Hockley, Calvin Wu, Susan E Shore
doi: https://doi.org/10.1101/2021.05.20.444983
Adam Hockley
1Kresge Hearing Research Institute, Department of Otolaryngology, Ann Arbor, MI, 48109, U.S.A.
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Calvin Wu
1Kresge Hearing Research Institute, Department of Otolaryngology, Ann Arbor, MI, 48109, U.S.A.
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Susan E Shore
1Kresge Hearing Research Institute, Department of Otolaryngology, Ann Arbor, MI, 48109, U.S.A.
2Department of Molecular and Integrative Physiology, Ann Arbor, MI, 48109, U.S.A.
3Department of Biomedical Engineering University of Michigan, Ann Arbor, MI, 48109, U.S.A.
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  • For correspondence: sushore@umich.edu
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ABSTRACT

Understanding speech, especially in noisy environments, is crucial to social interactions. Yet, as we age, speech processing can be disrupted by cochlear damage and the subsequent auditory nerve fiber degeneration. The most vulnerable—medium and high-threshold—auditory nerve fibers innervate various cell types in the cochlear nucleus, among which, the small cells are unique in receiving this input exclusively. Here, we characterize small cell firing characteristics, demonstrating superior temporal as well as intensity coding. We show that small-cell unique coding properties are facilitated by direct cholinergic input from the medial olivocochlear system. These results highlight the small cell–olivocochlear circuit as a key player in signal processing in noisy environments, which may be selectively degraded in aging or after noise insult.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 21, 2021.
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Cochlear nucleus small cells use olivocochlear collaterals to encode sounds in noise
Adam Hockley, Calvin Wu, Susan E Shore
bioRxiv 2021.05.20.444983; doi: https://doi.org/10.1101/2021.05.20.444983
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Cochlear nucleus small cells use olivocochlear collaterals to encode sounds in noise
Adam Hockley, Calvin Wu, Susan E Shore
bioRxiv 2021.05.20.444983; doi: https://doi.org/10.1101/2021.05.20.444983

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