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Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases

Xinyu Xiang, Tamta Arakhamia, Yari Carlomagno, Shikhar Dhingra, Manon Thierry, Michael DeTure, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, Anthony W. P. Fitzpatrick
doi: https://doi.org/10.1101/2021.05.24.445353
Xinyu Xiang
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA
2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA
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Tamta Arakhamia
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA
2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA
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Yari Carlomagno
4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
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Shikhar Dhingra
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA
2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA
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Manon Thierry
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA
2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA
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Michael DeTure
4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
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Casey N. Cook
4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
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Dennis W. Dickson
4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
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Leonard Petrucelli
4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
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Anthony W. P. Fitzpatrick
1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA
2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA
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  • For correspondence: Anthony.Fitzpatrick@columbia.edu
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Article Information

doi 
https://doi.org/10.1101/2021.05.24.445353
History 
  • May 25, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Xinyu Xiang†,1,2,3,
  2. Tamta Arakhamia†,1,2,3,
  3. Yari Carlomagno4,
  4. Shikhar Dhingra1,2,3,
  5. Manon Thierry1,2,3,
  6. Michael DeTure4,
  7. Casey N. Cook4,
  8. Dennis W. Dickson4,
  9. Leonard Petrucelli4 and
  10. Anthony W. P. Fitzpatrick*,1,2,3
  1. 1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA
  2. 2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
  3. 3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA
  4. 4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
  1. ↵*Correspondence to: Anthony.Fitzpatrick{at}columbia.edu.
  1. ↵† Equal contributions.

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Posted May 25, 2021.
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Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases
Xinyu Xiang, Tamta Arakhamia, Yari Carlomagno, Shikhar Dhingra, Manon Thierry, Michael DeTure, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, Anthony W. P. Fitzpatrick
bioRxiv 2021.05.24.445353; doi: https://doi.org/10.1101/2021.05.24.445353
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Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases
Xinyu Xiang, Tamta Arakhamia, Yari Carlomagno, Shikhar Dhingra, Manon Thierry, Michael DeTure, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, Anthony W. P. Fitzpatrick
bioRxiv 2021.05.24.445353; doi: https://doi.org/10.1101/2021.05.24.445353

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