Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases

Xinyu Xiang; Tamta Arakhamia; Yari Carlomagno; Shikhar Dhingra; Manon Thierry; Michael DeTure; Casey N. Cook; Dennis W. Dickson; Leonard Petrucelli; Anthony W. P. Fitzpatrick

doi:10.1101/2021.05.24.445353

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Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases

Xinyu Xiang, Tamta Arakhamia, Yari Carlomagno, Shikhar Dhingra, Manon Thierry, Michael DeTure, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, Anthony W. P. Fitzpatrick

doi: https://doi.org/10.1101/2021.05.24.445353

Xinyu Xiang

1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA

2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA

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Tamta Arakhamia

1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA

2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA

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Yari Carlomagno

4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA

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Shikhar Dhingra

1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA

2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA

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Manon Thierry

1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA

2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA

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Michael DeTure

4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA

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Casey N. Cook

4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA

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Dennis W. Dickson

4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA

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Leonard Petrucelli

4Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA

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Anthony W. P. Fitzpatrick

1Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA

2Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA

3Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY 10032, USA

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For correspondence: Anthony.Fitzpatrick@columbia.edu

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Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases

Xinyu Xiang, Tamta Arakhamia, Yari Carlomagno, Shikhar Dhingra, Manon Thierry, Michael DeTure, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, Anthony W. P. Fitzpatrick

bioRxiv 2021.05.24.445353; doi: https://doi.org/10.1101/2021.05.24.445353

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Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases

Xinyu Xiang, Tamta Arakhamia, Yari Carlomagno, Shikhar Dhingra, Manon Thierry, Michael DeTure, Casey N. Cook, Dennis W. Dickson, Leonard Petrucelli, Anthony W. P. Fitzpatrick

bioRxiv 2021.05.24.445353; doi: https://doi.org/10.1101/2021.05.24.445353

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