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Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder

Cigdem Gelegen, View ORCID ProfileDiana Cash, Katarina Ilic, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, Joana Lama, Karen Randall, Jonathan T. Brown, Svjetlana Kalanj-Bognar, Samuel Cooke, K Ray Chaudhuri, View ORCID ProfileClive Ballard, Paul Francis, Ivana Rosenzweig
doi: https://doi.org/10.1101/2021.05.26.445845
Cigdem Gelegen
1Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London (KCL), UK
2Basic and Clinical Neuroscience, IoPPN, KCL, UK
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Diana Cash
1Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London (KCL), UK
3BRAIN, Department of Neuroimaging, KCL, UK
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  • ORCID record for Diana Cash
Katarina Ilic
1Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London (KCL), UK
4University of Zagreb School of Medicine, Zagreb, Croatia
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Millie Sander
5College of Medicine and Health, University of Exeter, Exeter, UK
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Eugene Kim
3BRAIN, Department of Neuroimaging, KCL, UK
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Camilla Simmons
3BRAIN, Department of Neuroimaging, KCL, UK
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Michel Bernanos
3BRAIN, Department of Neuroimaging, KCL, UK
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Joana Lama
6Institute of Psychiatry, Psychology & Neuroscience, Wolfson Centre for Age-Related Diseases, Guy’s Campus, King’s College London, UK
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Karen Randall
3BRAIN, Department of Neuroimaging, KCL, UK
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Jonathan T. Brown
5College of Medicine and Health, University of Exeter, Exeter, UK
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Svjetlana Kalanj-Bognar
4University of Zagreb School of Medicine, Zagreb, Croatia
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Samuel Cooke
2Basic and Clinical Neuroscience, IoPPN, KCL, UK
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K Ray Chaudhuri
7King’s College London and Parkinson’s Foundation Centre of Excellence, King’s College Hospital, London, London, United Kingdom
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Clive Ballard
5College of Medicine and Health, University of Exeter, Exeter, UK
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Paul Francis
5College of Medicine and Health, University of Exeter, Exeter, UK
6Institute of Psychiatry, Psychology & Neuroscience, Wolfson Centre for Age-Related Diseases, Guy’s Campus, King’s College London, UK
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Ivana Rosenzweig
1Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King’s College London (KCL), UK
8Sleep Disorders Centre, GSTT, London, UK
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  • For correspondence: ivana.1.rosenzweig@kcl.ac.uk
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Abstract

Rapid eye movement (REM) sleep behaviour disorder (RBD) is a rare parasomnia that may predict the later occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵* joint authors

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Posted May 27, 2021.
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Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder
Cigdem Gelegen, Diana Cash, Katarina Ilic, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, Joana Lama, Karen Randall, Jonathan T. Brown, Svjetlana Kalanj-Bognar, Samuel Cooke, K Ray Chaudhuri, Clive Ballard, Paul Francis, Ivana Rosenzweig
bioRxiv 2021.05.26.445845; doi: https://doi.org/10.1101/2021.05.26.445845
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Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder
Cigdem Gelegen, Diana Cash, Katarina Ilic, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, Joana Lama, Karen Randall, Jonathan T. Brown, Svjetlana Kalanj-Bognar, Samuel Cooke, K Ray Chaudhuri, Clive Ballard, Paul Francis, Ivana Rosenzweig
bioRxiv 2021.05.26.445845; doi: https://doi.org/10.1101/2021.05.26.445845

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