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Distinct internal states interact to shape food choice by modulating sensorimotor processing at global and local scales

View ORCID ProfileDaniel Münch, View ORCID ProfileDennis Goldschmidt, View ORCID ProfileCarlos Ribeiro
doi: https://doi.org/10.1101/2021.05.27.445920
Daniel Münch
1Champalimaud Centre for the Unknown, Lisbon, Portugal
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  • For correspondence: carlos.ribeiro@neuro.fchampalimaud.org daniel.muench@research.fchampalimaud.org
Dennis Goldschmidt
1Champalimaud Centre for the Unknown, Lisbon, Portugal
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Carlos Ribeiro
1Champalimaud Centre for the Unknown, Lisbon, Portugal
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  • For correspondence: carlos.ribeiro@neuro.fchampalimaud.org daniel.muench@research.fchampalimaud.org
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Abstract

When deciding what to eat, animals evaluate sensory information about food quality alongside multiple ongoing internal states. How internal states interact to alter sensorimotor processing and shape decisions such as food choice remains poorly understood. Here, we use pan-neuronal volumetric activity imaging in the Drosophila brain to investigate the neuronal basis of internal state dependent nutrient appetites. We created a functional atlas of the ventral fly brain and find that metabolic state shapes sensorimotor processing across large sections of the neuropil. Reproductive state, in contrast, acts locally to define how sensory information is translated into feeding motor output. Thereby, these two states synergistically modulate protein-specific food intake and thus food choice. Finally, using a novel computational strategy, we identify driver lines innervating state-modulated regions and show that the newly identified borboleta region is sufficient to direct food choice towards protein-rich food. We therefore identify a generalizable principle by which distinct internal states are integrated to shape decision-making and propose a strategy to uncover and functionally validate how internal states shape behavior.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 27, 2021.
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Distinct internal states interact to shape food choice by modulating sensorimotor processing at global and local scales
Daniel Münch, Dennis Goldschmidt, Carlos Ribeiro
bioRxiv 2021.05.27.445920; doi: https://doi.org/10.1101/2021.05.27.445920
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Distinct internal states interact to shape food choice by modulating sensorimotor processing at global and local scales
Daniel Münch, Dennis Goldschmidt, Carlos Ribeiro
bioRxiv 2021.05.27.445920; doi: https://doi.org/10.1101/2021.05.27.445920

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