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Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium
View ORCID ProfileLindsay Fernández-Rhodes, Mariaelisa Graff, Victoria L. Buchanan, View ORCID ProfileAnne E. Justice, Heather M. Highland, Xiuqing Guo, Kristin L. Young, Kaustubh Adhikari, Nicholette (Palmer) Allred, Jennifer E. Below, Jonathan Bradfield, Alexandre C. Pereira, LáShauntá Glover, Daeeun Kim, Adam G. Lilly, Poojan Shrestha, Alvin G. Thomas, Xinruo Zhang, Minhui Chen, View ORCID ProfileCharleston W. K. Chiang, Sara Pulit, Andrea Horimoto, Jose E Krieger, Marta Guindo-Martinez, Michael Preuss, Claudia Schumann, Roelof A.J. Smit, Gabriela Torres-Mejía, Victor Acuña-Alonzo, Gabriel Bedoya, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Rolando González-José, Giovanni Poletti, Francisco Rothhammer, Hakon Hakonarson, Robert Igo, Sharon G Adler, Susanne B Nicholas, Sudha K. Iyengar, Stephanie M. Gogarten, Carmen R. Isasi, George Papnicolaou, Adrienne M. Stilp, Qibin Qi, Minjung Kho, View ORCID ProfileJennifer A. Smith, Carl Langfeld, Lynne Wagenknecht, Roberta Mckean-Cowdin, Xiaoyi Raymond Gao, Darryl Nousome, David V. Conti, Ye Feng, Matthew A. Allison, Zorayr Arzumanyan, Thomas A. Buchanan, Yii-Der Ida Chen, Pauline M. Genter, Mark O. Goodarzi, Yang Hai, Willa Hsueh, Eli Ipp, Fouad R. Kandeel, Kelvin Lam, Xiaohui Li, Jerry L. Nadler, Leslie J. Raffel, Kaye Roll, Kevin Sandow, Jingyi Tan, Kent D. Taylor, Anny H. Xiang, Jie Yao, Astride Audirac-Chalifour, Jose de Jesus Peralta Romero, Fernando Hartwig, Bernando Horta, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Donna E. Lehman, Sobha Puppala, Laura Fejerman, Esther M. John, Carlos Aguilar-Salinas, Noël P. Burtt, Jose C. Florez, Humberto García-Ortíz, Clicerio González-Villalpando, Josep Maria Mercader, Lorena Orozco, Teresa Tusié, Estela Blanco, Sheila Gahagan, Nancy J. Cox, Craig Hanis, Nancy F. Butte, Shelley A. Cole, Anthony G. Commuzzie, V. Saroja Voruganti, Rebecca Rohde, Yujie Wang, Tamar Sofer, Elad Ziv, Struan F.A. Grant, Andres Ruiz-Linares, Jerome I. Rotter, Christopher A. Haiman, Esteban J. Parra, Miguel Cruz, Ruth J.F. Loos, Kari E. North
doi: https://doi.org/10.1101/2021.05.27.445969
Lindsay Fernández-Rhodes
1Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Mariaelisa Graff
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Victoria L. Buchanan
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Anne E. Justice
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
3Department of Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA
Heather M. Highland
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Xiuqing Guo
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Kristin L. Young
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Kaustubh Adhikari
5School of Mathematics and Statistics, Faculty of Science, Technology, Engineering and Mathematics, The Open University, Milton Keynes, United Kingdom
Nicholette (Palmer) Allred
6Center for Diabetes Research, Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine Winston-Salem, NC, USA
Jennifer E. Below
7Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Jonathan Bradfield
8Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Alexandre C. Pereira
9Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, Brazil
LáShauntá Glover
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Daeeun Kim
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Adam G. Lilly
10Department of Sociology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
11Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Poojan Shrestha
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
12Division of Pediatric and Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Alvin G. Thomas
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Xinruo Zhang
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Minhui Chen
13Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Charleston W. K. Chiang
13Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
14Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA, USA
Sara Pulit
15Vertex Pharmaceuticals, Oxford, United Kingdom
Andrea Horimoto
9Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, Brazil
Jose E Krieger
9Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, Brazil
Marta Guindo-Martinez
16The Charles Bronfman Institutes for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA
17The Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Michael Preuss
17The Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Claudia Schumann
18Hasso Plattner Institute, University of Potsdam, Digital Health Center, Potsdam Germany
Roelof A.J. Smit
17The Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Gabriela Torres-Mejía
19Department of Research in Cardiovascular Diseases Diabetes Mellitus and Cancer, Population Health Research Center, National Institute of Public Health, Cuernavaca, Morelos, Mexico
Victor Acuña-Alonzo
20National Institute of Anthropology and History, Mexico City, Mexico
Gabriel Bedoya
21Genética Molecular, Universidad de Antioquia, Medellín, Colombia
Maria-Cátira Bortolini
22Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
Samuel Canizales-Quinteros
23Unidad de Genomica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Carla Gallo
24Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
Rolando González-José
25Instituto Patagonico de Ciencias Sociales y Humanas, Centro Nacional Patagonico, CONICET, Puerto Madryn, U9129ACD, Argentina
Giovanni Poletti
24Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú
Francisco Rothhammer
26Instituto de Alta Investigación, Universidad de Tarapaca, Arica, Chile
Hakon Hakonarson
8Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Robert Igo
27Department of Population and Quantiative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
Sharon G Adler
28Harbor-UCLA Medical Center Division of Nephrology and Hypertension, Torrance, CA, USA
Susanne B Nicholas
29Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
Sudha K. Iyengar
27Department of Population and Quantiative Health Sciences, Case Western Reserve University, Cleveland, OH, USA
Stephanie M. Gogarten
30Department of Biostatistics, University of Washington, Seattle, WA, USA
Carmen R. Isasi
31Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
George Papnicolaou
32National Heart, Lunch and Blood Institute, Bethesda, MD, USA
Adrienne M. Stilp
30Department of Biostatistics, University of Washington, Seattle, WA, USA
Qibin Qi
31Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA
Minjung Kho
33Department of Epidemiology, School of Public Health, University of Michigan, Ann Harbor, MI, USA
Jennifer A. Smith
33Department of Epidemiology, School of Public Health, University of Michigan, Ann Harbor, MI, USA
Carl Langfeld
34Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC USA
Lynne Wagenknecht
35Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC USA
Roberta Mckean-Cowdin
36Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Xiaoyi Raymond Gao
37Department of Opthalmology and Visual Sciences, Department of Biomedical Informatics, Division of Human Genetics, The Ohio State University, Columbus, OH, USA
Darryl Nousome
36Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
David V. Conti
13Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Ye Feng
36Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Matthew A. Allison
38Department of Family Medicine and Public Health, University of California, San Diego, CA, USA
Zorayr Arzumanyan
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Thomas A. Buchanan
39Department of Physiology and Biophysics and Department of Medicine, Keck School of Medicine of USC, Los Angeles, CA USA
Yii-Der Ida Chen
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Pauline M. Genter
40Department of Medicine, Division of Endocrinology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA
Mark O. Goodarzi
41Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA USA
Yang Hai
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Willa Hsueh
42Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Eli Ipp
29Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CA, USA
40Department of Medicine, Division of Endocrinology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA USA
Fouad R. Kandeel
44Department of Translational Research & Cellular Therapeutics, Beckman Research Institute of City of Hope, Duarte, CA USA
Kelvin Lam
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Xiaohui Li
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Jerry L. Nadler
45New York Medical College, School of Medicine, Valhalla, NY, USA
Leslie J. Raffel
46Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, CA, USA
Kaye Roll
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Kevin Sandow
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Jingyi Tan
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Kent D. Taylor
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Anny H. Xiang
47Research and Evaluation Branch, Kaiser Permanente of Southern California, Pasadena, California, USA
Jie Yao
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Astride Audirac-Chalifour
48Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, CMNSXX1-IMSS, Mexico City, Mexico
Jose de Jesus Peralta Romero
49Medical Research Unit in Biochemistry. Hospital of High Medical Specialty “Dr. Bernardo Sepulveda”. National Medical Center Siglo XXI, Mexican Institute of Social Security, Mexico City, Mexico
Fernando Hartwig
50Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
Bernando Horta
50Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil
John Blangero
51Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX, USA
Joanne E. Curran
51Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX, USA
Ravindranath Duggirala
51Department of Human Genetics and South Texas Diabetes and Obesity Institute, School of Medicine, University of Texas Rio Grande Valley, Brownsville and Edinburg, TX, USA
Donna E. Lehman
52Department of Medicine, School of Medicine, University of Texas Health San Antonio, San Antonio, TX, USA
Sobha Puppala
53Department of Internal Medicine, Wake Forest University, Winston-Salem, NC, USA
Laura Fejerman
54Department of Public Health Sciences, School of Medicine, and Comprehensive Cancer Center, University of California Davis, Davis, CA, USA
Esther M. John
55Departments of Epidemiology and Population Health and of Medicine (Oncology); Stanford University, School of Medicine, Stanford, CA, USA
Carlos Aguilar-Salinas
56Division of Nutrition, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Noël P. Burtt
57Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
Jose C. Florez
57Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
58Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA
59Department of Medicine, Harvard Medical School, Boston, MA, USA
Humberto García-Ortíz
60Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Clicerio González-Villalpando
61Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Pública, Mexico City, Mexico
Josep Maria Mercader
57Programs in Metabolism and Medical & Population Genetics, Broad Institute, Cambridge, MA, USA
59Department of Medicine, Harvard Medical School, Boston, MA, USA
62Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA
Lorena Orozco
60Laboratorio de Inmunogenómica y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica, Mexico City, Mexico
Teresa Tusié
63Unidad de Biología Molecular y Medicina Genómica, Instituto de Investigaciones Biomédicas, UNAM/ Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Estela Blanco
64Center for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA
Sheila Gahagan
64Center for Community Health, Division of Academic General Pediatrics, University of California at San Diego, San Diego, CA
Nancy J. Cox
7Vanderbilt Genetics Institute, Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
Craig Hanis
65University of Texas Health Science Center at Houston, Houston, TX, USA
Nancy F. Butte
66USDA/ARS Children’s Nutrition Research Center, Department Pediatrics, Baylor College of Medicine, Houston, TX, USA
Shelley A. Cole
67Population Health Program, Texas Biomedical Research Institute, San Antonio, TX, USA
Anthony G. Commuzzie
68The Obesity Society, Silver Spring, MD, USA
V. Saroja Voruganti
69Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina, Kannapolis, NC, USA
Rebecca Rohde
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Yujie Wang
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Tamar Sofer
70Department of Medicine, Harvard Medical School, and Division of Sleep and Circadian Disorders, Brigham and Women’s hospital, Boston MA, USA
Elad Ziv
71Division of General Internal Medicine, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA
Struan F.A. Grant
8Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA
Andres Ruiz-Linares
72Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai, China
73Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, UK
74UMR 7268 ADES, CNRS, Aix-Marseille Université, EFS, Faculté de médecine Timone, Marseille, France
Jerome I. Rotter
4The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
Christopher A. Haiman
36Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Esteban J. Parra
75Department of Anthropology, University of Toronto- Mississauga, Mississauga, ON, Canada
Miguel Cruz
48Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, CMNSXX1-IMSS, Mexico City, Mexico
Ruth J.F. Loos
17The Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
Kari E. North
2Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
ABSTRACT
Hispanic/Latinos have been underrepresented in genome-wide association studies (GWAS) for anthropometric traits despite notable anthropometric variability with ancestry proportions, and a high burden of growth stunting and overweight/obesity in Hispanic/Latino populations. This address this knowledge gap, we analyzed densely-imputed genetic data in a sample of Hispanic/Latino adults, to identify and fine-map common genetic variants associated with body mass index (BMI), height, and BMI-adjusted waist-to-hip ratio (WHRadjBMI). We conducted a GWAS of 18 adult studies/consortia as part of the Hispanic/Latino Anthropometry (HISLA) Consortium (Stage 1, n=59,769) and validated our findings in 9 additional studies (HISLA Stage 2, n=9,336). We conducted a trans-ethnic GWAS with summary statistics from HISLA Stage 1 and existing consortia of European and African ancestries. In our HISLA Stage 1+2 analyses, we discovered one novel BMI locus, two novel signals in established loci for BMI, and one secondary signal in an established locus for height. In our trans-ethnic meta-analysis, we identified three additional novel BMI loci, one novel height locus, and one novel WHRadjBMI locus. We also identified three secondary signals for BMI, 29 for height, and two for WHRadjBMI. We replicated 64 established anthropometric loci in Hispanic/Latino populations at genome-wide significance (28% of previously-reported index SNP anthropometric associations). Trans-ethnic meta-analysis of the three ancestries showed a small-to-moderate impact of uncorrected population stratification on the resulting effect size estimates. Our novel findings demonstrate that future studies may also benefit from leveraging differences in linkage disequilibrium patterns to discover novel loci and additional signals with less residual population stratification.
Competing Interest Statement
Stephanie M. Gogarten (SMG) and Adrienne M. Stilp (AMS) received funding from Seven Bridges Genomics to develop tools for the NHLBI BioData Catalyst consortium. All others authors declare no competing interests.
Footnotes
↵* Co-first authors.
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY 4.0 International license.
Posted May 29, 2021.
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium
Lindsay Fernández-Rhodes, Mariaelisa Graff, Victoria L. Buchanan, Anne E. Justice, Heather M. Highland, Xiuqing Guo, Kristin L. Young, Kaustubh Adhikari, Nicholette (Palmer) Allred, Jennifer E. Below, Jonathan Bradfield, Alexandre C. Pereira, LáShauntá Glover, Daeeun Kim, Adam G. Lilly, Poojan Shrestha, Alvin G. Thomas, Xinruo Zhang, Minhui Chen, Charleston W. K. Chiang, Sara Pulit, Andrea Horimoto, Jose E Krieger, Marta Guindo-Martinez, Michael Preuss, Claudia Schumann, Roelof A.J. Smit, Gabriela Torres-Mejía, Victor Acuña-Alonzo, Gabriel Bedoya, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Rolando González-José, Giovanni Poletti, Francisco Rothhammer, Hakon Hakonarson, Robert Igo, Sharon G Adler, Susanne B Nicholas, Sudha K. Iyengar, Stephanie M. Gogarten, Carmen R. Isasi, George Papnicolaou, Adrienne M. Stilp, Qibin Qi, Minjung Kho, Jennifer A. Smith, Carl Langfeld, Lynne Wagenknecht, Roberta Mckean-Cowdin, Xiaoyi Raymond Gao, Darryl Nousome, David V. Conti, Ye Feng, Matthew A. Allison, Zorayr Arzumanyan, Thomas A. Buchanan, Yii-Der Ida Chen, Pauline M. Genter, Mark O. Goodarzi, Yang Hai, Willa Hsueh, Eli Ipp, Fouad R. Kandeel, Kelvin Lam, Xiaohui Li, Jerry L. Nadler, Leslie J. Raffel, Kaye Roll, Kevin Sandow, Jingyi Tan, Kent D. Taylor, Anny H. Xiang, Jie Yao, Astride Audirac-Chalifour, Jose de Jesus Peralta Romero, Fernando Hartwig, Bernando Horta, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Donna E. Lehman, Sobha Puppala, Laura Fejerman, Esther M. John, Carlos Aguilar-Salinas, Noël P. Burtt, Jose C. Florez, Humberto García-Ortíz, Clicerio González-Villalpando, Josep Maria Mercader, Lorena Orozco, Teresa Tusié, Estela Blanco, Sheila Gahagan, Nancy J. Cox, Craig Hanis, Nancy F. Butte, Shelley A. Cole, Anthony G. Commuzzie, V. Saroja Voruganti, Rebecca Rohde, Yujie Wang, Tamar Sofer, Elad Ziv, Struan F.A. Grant, Andres Ruiz-Linares, Jerome I. Rotter, Christopher A. Haiman, Esteban J. Parra, Miguel Cruz, Ruth J.F. Loos, Kari E. North
bioRxiv 2021.05.27.445969; doi: https://doi.org/10.1101/2021.05.27.445969
Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits - the Hispanic/Latino Anthropometry Consortium
Lindsay Fernández-Rhodes, Mariaelisa Graff, Victoria L. Buchanan, Anne E. Justice, Heather M. Highland, Xiuqing Guo, Kristin L. Young, Kaustubh Adhikari, Nicholette (Palmer) Allred, Jennifer E. Below, Jonathan Bradfield, Alexandre C. Pereira, LáShauntá Glover, Daeeun Kim, Adam G. Lilly, Poojan Shrestha, Alvin G. Thomas, Xinruo Zhang, Minhui Chen, Charleston W. K. Chiang, Sara Pulit, Andrea Horimoto, Jose E Krieger, Marta Guindo-Martinez, Michael Preuss, Claudia Schumann, Roelof A.J. Smit, Gabriela Torres-Mejía, Victor Acuña-Alonzo, Gabriel Bedoya, Maria-Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Rolando González-José, Giovanni Poletti, Francisco Rothhammer, Hakon Hakonarson, Robert Igo, Sharon G Adler, Susanne B Nicholas, Sudha K. Iyengar, Stephanie M. Gogarten, Carmen R. Isasi, George Papnicolaou, Adrienne M. Stilp, Qibin Qi, Minjung Kho, Jennifer A. Smith, Carl Langfeld, Lynne Wagenknecht, Roberta Mckean-Cowdin, Xiaoyi Raymond Gao, Darryl Nousome, David V. Conti, Ye Feng, Matthew A. Allison, Zorayr Arzumanyan, Thomas A. Buchanan, Yii-Der Ida Chen, Pauline M. Genter, Mark O. Goodarzi, Yang Hai, Willa Hsueh, Eli Ipp, Fouad R. Kandeel, Kelvin Lam, Xiaohui Li, Jerry L. Nadler, Leslie J. Raffel, Kaye Roll, Kevin Sandow, Jingyi Tan, Kent D. Taylor, Anny H. Xiang, Jie Yao, Astride Audirac-Chalifour, Jose de Jesus Peralta Romero, Fernando Hartwig, Bernando Horta, John Blangero, Joanne E. Curran, Ravindranath Duggirala, Donna E. Lehman, Sobha Puppala, Laura Fejerman, Esther M. John, Carlos Aguilar-Salinas, Noël P. Burtt, Jose C. Florez, Humberto García-Ortíz, Clicerio González-Villalpando, Josep Maria Mercader, Lorena Orozco, Teresa Tusié, Estela Blanco, Sheila Gahagan, Nancy J. Cox, Craig Hanis, Nancy F. Butte, Shelley A. Cole, Anthony G. Commuzzie, V. Saroja Voruganti, Rebecca Rohde, Yujie Wang, Tamar Sofer, Elad Ziv, Struan F.A. Grant, Andres Ruiz-Linares, Jerome I. Rotter, Christopher A. Haiman, Esteban J. Parra, Miguel Cruz, Ruth J.F. Loos, Kari E. North
bioRxiv 2021.05.27.445969; doi: https://doi.org/10.1101/2021.05.27.445969
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