New Results
Obesity-instructed TREM2high macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolution
Ayshwarya Subramanian, Katherine Vernon, View ORCID ProfileYiming Zhou, Jamie L. Marshall, Maria Alimova, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Heller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Astrid Weins, Alexandra-Chloe Villani, Steven L. Chang, Orit Rosenblatt-Rosen, View ORCID ProfileJillian L. Shaw, Aviv Regev, View ORCID ProfileAnna Greka
doi: https://doi.org/10.1101/2021.05.30.446342
Ayshwarya Subramanian
1Klarman Cell Observatory; Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Katherine Vernon
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Yiming Zhou
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
8Medical Research Center; Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
Jamie L. Marshall
2Kidney Disease Initiative; Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Maria Alimova
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Fan Zhang
4Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School; Boston, MA, USA
Michal Slyper
1Klarman Cell Observatory; Broad Institute of MIT and Harvard, Cambridge, MA, USA
6Genentech; 1 DNA Way, South San Francisco, CA, USA
Julia Waldman
1Klarman Cell Observatory; Broad Institute of MIT and Harvard, Cambridge, MA, USA
Monica S. Montesinos
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
10Morphic Therapeutic; Waltham, MA, USA
Danielle Dionne
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Lan T. Nguyen
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Michael S. Cuoco
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Dan Dubinsky
1Klarman Cell Observatory; Broad Institute of MIT and Harvard, Cambridge, MA, USA
Jason Purnell
1Klarman Cell Observatory; Broad Institute of MIT and Harvard, Cambridge, MA, USA
Keith Heller
2Kidney Disease Initiative; Broad Institute of MIT and Harvard, Cambridge, MA, USA
Samuel H. Sturner
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Elizabeth Grinkevich
2Kidney Disease Initiative; Broad Institute of MIT and Harvard, Cambridge, MA, USA
Ayan Ghoshal
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Astrid Weins
4Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School; Boston, MA, USA
5Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School; Boston, MA, USA
Alexandra-Chloe Villani
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Steven L. Chang
9Center for Surgery and Public Health, Brigham and Women’s Hospital; Boston, MA, USA; Division of Urology, Brigham and Women’s Hospital; Boston, MA, USA
Orit Rosenblatt-Rosen
6Genentech; 1 DNA Way, South San Francisco, CA, USA
Jillian L. Shaw
2Kidney Disease Initiative; Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
Aviv Regev
1Klarman Cell Observatory; Broad Institute of MIT and Harvard, Cambridge, MA, USA
6Genentech; 1 DNA Way, South San Francisco, CA, USA
7Howard Hughes Medical Institute, Department of Biology; Massachusetts Institute of Technology, Cambridge, MA, USA
Anna Greka
2Kidney Disease Initiative; Broad Institute of MIT and Harvard, Cambridge, MA, USA
3Broad Institute of MIT and Harvard; Cambridge, MA, USA
4Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School; Boston, MA, USA
Posted May 30, 2021.
Obesity-instructed TREM2high macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolution
Ayshwarya Subramanian, Katherine Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Heller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Astrid Weins, Alexandra-Chloe Villani, Steven L. Chang, Orit Rosenblatt-Rosen, Jillian L. Shaw, Aviv Regev, Anna Greka
bioRxiv 2021.05.30.446342; doi: https://doi.org/10.1101/2021.05.30.446342
Obesity-instructed TREM2high macrophages identified by comparative analysis of diabetic mouse and human kidney at single cell resolution
Ayshwarya Subramanian, Katherine Vernon, Yiming Zhou, Jamie L. Marshall, Maria Alimova, Fan Zhang, Michal Slyper, Julia Waldman, Monica S. Montesinos, Danielle Dionne, Lan T. Nguyen, Michael S. Cuoco, Dan Dubinsky, Jason Purnell, Keith Heller, Samuel H. Sturner, Elizabeth Grinkevich, Ayan Ghoshal, Astrid Weins, Alexandra-Chloe Villani, Steven L. Chang, Orit Rosenblatt-Rosen, Jillian L. Shaw, Aviv Regev, Anna Greka
bioRxiv 2021.05.30.446342; doi: https://doi.org/10.1101/2021.05.30.446342
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