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Center-surround interactions underlie bipolar cell motion sensing in the mouse retina

Sarah Strauss, Maria M Korympidou, Yanli Ran, View ORCID ProfileKatrin Franke, View ORCID ProfileTimm Schubert, View ORCID ProfileTom Baden, View ORCID ProfilePhilipp Berens, View ORCID ProfileThomas Euler, View ORCID ProfileAnna L Vlasits
doi: https://doi.org/10.1101/2021.05.31.446404
Sarah Strauss
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
3Bernstein Center for Computational Neuroscience, University of Tuebingen, Tuebingen, Germany
4Graduate School of Neuroscience, International Max Planck Research School, University of Tuebingen, Tuebingen, Germany
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Maria M Korympidou
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
4Graduate School of Neuroscience, International Max Planck Research School, University of Tuebingen, Tuebingen, Germany
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Yanli Ran
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
4Graduate School of Neuroscience, International Max Planck Research School, University of Tuebingen, Tuebingen, Germany
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Katrin Franke
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
3Bernstein Center for Computational Neuroscience, University of Tuebingen, Tuebingen, Germany
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  • ORCID record for Katrin Franke
Timm Schubert
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
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Tom Baden
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
5School of Life Sciences, University of Sussex, Brighton, UK
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  • ORCID record for Tom Baden
Philipp Berens
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
3Bernstein Center for Computational Neuroscience, University of Tuebingen, Tuebingen, Germany
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Thomas Euler
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
3Bernstein Center for Computational Neuroscience, University of Tuebingen, Tuebingen, Germany
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  • For correspondence: anna-louise.vlasits@uni-tuebingen.de thomas.euler@cin.uni-tuebingen.de
Anna L Vlasits
1Institute for Ophthalmic Research, University of Tuebingen, Tuebingen, Germany
2Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany
3Bernstein Center for Computational Neuroscience, University of Tuebingen, Tuebingen, Germany
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  • ORCID record for Anna L Vlasits
  • For correspondence: anna-louise.vlasits@uni-tuebingen.de thomas.euler@cin.uni-tuebingen.de
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Abstract

Motion is a critical aspect of vision. We studied the representation of motion in mouse retinal bipolar cells and found, surprisingly, that some bipolar cells possess motion-sensing capabilities that rely on their center-surround receptive fields. Using a glutamate sensor, we directly observed motion-sensitive bipolar cell synaptic output, which was strongest for local motion and dependent on the motion’s origin. We characterized bipolar cell receptive fields and found that there are motion and non-motion sensitive bipolar cell types, the majority being motion sensitive. Next, we used these bipolar cell receptive fields along with connectomics to design biophysical models of downstream cells. The models and experiments demonstrated that bipolar cells pass motion-sensitive excitation to starburst amacrine cells through direction-specific signals mediated by bipolar cells’ center-surround receptive field structure. As bipolar cells provide excitation to most amacrine and ganglion cells, their motion sensitivity may contribute to motion processing throughout the visual system.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license.
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Posted May 31, 2021.
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Center-surround interactions underlie bipolar cell motion sensing in the mouse retina
Sarah Strauss, Maria M Korympidou, Yanli Ran, Katrin Franke, Timm Schubert, Tom Baden, Philipp Berens, Thomas Euler, Anna L Vlasits
bioRxiv 2021.05.31.446404; doi: https://doi.org/10.1101/2021.05.31.446404
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Center-surround interactions underlie bipolar cell motion sensing in the mouse retina
Sarah Strauss, Maria M Korympidou, Yanli Ran, Katrin Franke, Timm Schubert, Tom Baden, Philipp Berens, Thomas Euler, Anna L Vlasits
bioRxiv 2021.05.31.446404; doi: https://doi.org/10.1101/2021.05.31.446404

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