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Functional organization of frontoparietal cortex in the marmoset investigated with awake resting-state fMRI

Yuki Hori, Justine C. Cléry, David J. Schaeffer, Ravi S. Menon, Stefan Everling
doi: https://doi.org/10.1101/2021.05.31.446481
Yuki Hori
1Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, ON, Canada, N6A 5B7
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Justine C. Cléry
1Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, ON, Canada, N6A 5B7
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David J. Schaeffer
2Department of Neurobiology, University of Pittsburgh, PA, United States
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Ravi S. Menon
1Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, ON, Canada, N6A 5B7
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Stefan Everling
1Centre for Functional and Metabolic Mapping, Robarts Research Institute, The University of Western Ontario, ON, Canada, N6A 5B7
3Department of Physiology and Pharmacology, The University of Western Ontario, ON, Canada, N6A 5C1
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  • For correspondence: severlin@uwo.ca
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Abstract

Frontoparietal networks contribute to complex cognitive functions in humans and macaques such as working memory, attention, task-switching, response suppression, grasping, reaching, and eye movement control. However, little is known about the organization of frontoparietal networks in the New World common marmoset monkey (Callithrix jacchus) which is now widely recognized as a powerful nonhuman primate experimental animal. In this study, we employed hierarchical clustering of interareal BOLD signals to investigate the hypothesis that the organization of the frontoparietal cortex in the marmoset follows the organizational principles of the macaque frontoparietal system. We found that the posterior part of the lateral frontal cortex (premotor regions) was functionally connected to the anterior parietal areas while more anterior frontal regions (frontal eye field (FEF)) were connected to more posterior parietal areas (the area around lateral intraparietal area (LIP)). These overarching patterns of inter-areal organization are consistent with a recent macaque study. These findings demonstrate parallel frontoparietal processing streams in marmosets and support the functional homologies of FEF-LIP and premotor-anterior parietal pathways between marmoset and macaque.

Significant Statement Frontoparietal networks contribute to many cognitive functions in humans and macaques, but little is known about the organization of frontoparietal networks in the New World common marmoset monkey. Here, we investigated the hypothesis that the organization of the frontoparietal cortex in the marmoset follows the organizational principles of the macaque frontoparietal system. These frontoparietal connection showed overarching pattern of interareal organization consistent with Old world monkeys. These findings demonstrate parallel frontoparietal processing streams in marmosets.

Competing Interest Statement

The authors have declared no competing interest.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted May 31, 2021.
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Functional organization of frontoparietal cortex in the marmoset investigated with awake resting-state fMRI
Yuki Hori, Justine C. Cléry, David J. Schaeffer, Ravi S. Menon, Stefan Everling
bioRxiv 2021.05.31.446481; doi: https://doi.org/10.1101/2021.05.31.446481
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Functional organization of frontoparietal cortex in the marmoset investigated with awake resting-state fMRI
Yuki Hori, Justine C. Cléry, David J. Schaeffer, Ravi S. Menon, Stefan Everling
bioRxiv 2021.05.31.446481; doi: https://doi.org/10.1101/2021.05.31.446481

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