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Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein aggregates within processing bodies
View ORCID ProfileAidan M. Fenix, View ORCID ProfileYuichiro Miyaoka, View ORCID ProfileAlessandro Bertero, View ORCID ProfileSteven Blue, View ORCID ProfileMatthew J. Spindler, Kenneth K. B. Tan, View ORCID ProfileJuan Perez-Bermejo, Amanda H. Chan, Steven J. Mayer, Trieu Nguyen, Caitlin R. Russell, Paweena Lizarraga, Annie Truong, Po-Lin So, Aishwarya Kulkarni, Kashish Chetal, View ORCID ProfileShashank Sathe, View ORCID ProfileNathan J. Sniadecki, View ORCID ProfileGene W. Yeo, View ORCID ProfileCharles E. Murry, Bruce R. Conklin, View ORCID ProfileNathan Salomonis
doi: https://doi.org/10.1101/2021.06.02.446820
Aidan M. Fenix
1Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
2Center for Cardiovascular Biology, University of Washington, 850 Republican Street, Brotman Building, Seattle, WA 98109, USA
3Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA
Yuichiro Miyaoka
4Regenerative Medicine Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Alessandro Bertero
1Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
2Center for Cardiovascular Biology, University of Washington, 850 Republican Street, Brotman Building, Seattle, WA 98109, USA
3Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA
Steven Blue
8Department of Cellular and Molecular Medicine, Stem Cell Program, and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Matthew J. Spindler
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Kenneth K. B. Tan
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Juan Perez-Bermejo
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Amanda H. Chan
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Steven J. Mayer
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Trieu Nguyen
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Caitlin R. Russell
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Paweena Lizarraga
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Annie Truong
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Po-Lin So
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
Aishwarya Kulkarni
6Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, Ohio, 45221, USA
7Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, OH 45229, USA
Kashish Chetal
7Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, OH 45229, USA
Shashank Sathe
8Department of Cellular and Molecular Medicine, Stem Cell Program, and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Nathan J. Sniadecki
1Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
2Center for Cardiovascular Biology, University of Washington, 850 Republican Street, Brotman Building, Seattle, WA 98109, USA
3Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA
9Department of Mechanical Engineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98105, USA
10Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98105, USA
Gene W. Yeo
8Department of Cellular and Molecular Medicine, Stem Cell Program, and Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Charles E. Murry
1Department of Laboratory Medicine and Pathology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
2Center for Cardiovascular Biology, University of Washington, 850 Republican Street, Brotman Building, Seattle, WA 98109, USA
3Institute for Stem Cell and Regenerative Medicine, University of Washington, 850 Republican Street, Seattle, WA 98109, USA
10Department of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, WA 98105, USA
11Department of Medicine/Cardiology, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
12Sana Biotechnology, 188 E Blaine Street, Seattle, WA 98102, USA
Bruce R. Conklin
5Gladstone Institutes, 1650 Owens St. San Francisco CA 94158, USA
13Departments of Medicine, Cellular and Molecular Pharmacology, and Ophthalmology, University of California San Francisco, CA 94158, USA
Nathan Salomonis
7Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, OH 45229, USA
14Departments of Pediatrics, University of Cincinnati, OH 45229, USA
Posted June 03, 2021.
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein aggregates within processing bodies
Aidan M. Fenix, Yuichiro Miyaoka, Alessandro Bertero, Steven Blue, Matthew J. Spindler, Kenneth K. B. Tan, Juan Perez-Bermejo, Amanda H. Chan, Steven J. Mayer, Trieu Nguyen, Caitlin R. Russell, Paweena Lizarraga, Annie Truong, Po-Lin So, Aishwarya Kulkarni, Kashish Chetal, Shashank Sathe, Nathan J. Sniadecki, Gene W. Yeo, Charles E. Murry, Bruce R. Conklin, Nathan Salomonis
bioRxiv 2021.06.02.446820; doi: https://doi.org/10.1101/2021.06.02.446820
Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein aggregates within processing bodies
Aidan M. Fenix, Yuichiro Miyaoka, Alessandro Bertero, Steven Blue, Matthew J. Spindler, Kenneth K. B. Tan, Juan Perez-Bermejo, Amanda H. Chan, Steven J. Mayer, Trieu Nguyen, Caitlin R. Russell, Paweena Lizarraga, Annie Truong, Po-Lin So, Aishwarya Kulkarni, Kashish Chetal, Shashank Sathe, Nathan J. Sniadecki, Gene W. Yeo, Charles E. Murry, Bruce R. Conklin, Nathan Salomonis
bioRxiv 2021.06.02.446820; doi: https://doi.org/10.1101/2021.06.02.446820
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