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Aging-related cerebral microvascular changes visualized using Ultrasound Localization Microscopy in the living mouse

View ORCID ProfileMatthew R. Lowerison, Nathiya Chandra Sekaran, Wei Zhang, View ORCID ProfileZhijie Dong, Xi Chen, View ORCID ProfileDaniel A. Llano, View ORCID ProfilePengfei Song
doi: https://doi.org/10.1101/2021.06.04.447141
Matthew R. Lowerison
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
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Nathiya Chandra Sekaran
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL
3Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL
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Wei Zhang
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
4Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Wuhan City, Hubei Province, China
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Zhijie Dong
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
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Xi Chen
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
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Daniel A. Llano
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL
3Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL
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  • For correspondence: d-llano@illinois.edu songp@illinois.edu
Pengfei Song
1Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL
2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL
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  • For correspondence: d-llano@illinois.edu songp@illinois.edu
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Abstract

Aging-related cognitive decline is an emerging health crisis; however, no established unifying mechanism has been identified for the cognitive impairments seen in an aging population. A vascular hypothesis of cognitive decline has been proposed but is difficult to test given the contradictory radiologic needs of high-fidelity microvascular imaging resolution and a broad and deep brain imaging field of view. Super-resolution ultrasound localization microscopy (ULM) offers a potential solution by exploiting circulating microbubbles to achieve a vascular resolution approaching the capillary scale without sacrificing imaging depth. In this report, we apply ULM imaging to a mouse model of aging and quantify differences in cerebral vascularity, blood velocity, and vessel tortuosity across several brain regions. We found significant decreases in blood velocity, and significant increases in vascular tortuosity, across all brain regions in the aged cohort, and significant decreases in blood volume in the cortex. These data provide the first-ever measurements of subcortical microvascular dynamics in vivo and reveal that aging has a major impact on these measurements.

Competing Interest Statement

The authors have declared no competing interest.

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The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.
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Posted June 07, 2021.
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Aging-related cerebral microvascular changes visualized using Ultrasound Localization Microscopy in the living mouse
Matthew R. Lowerison, Nathiya Chandra Sekaran, Wei Zhang, Zhijie Dong, Xi Chen, Daniel A. Llano, Pengfei Song
bioRxiv 2021.06.04.447141; doi: https://doi.org/10.1101/2021.06.04.447141
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Aging-related cerebral microvascular changes visualized using Ultrasound Localization Microscopy in the living mouse
Matthew R. Lowerison, Nathiya Chandra Sekaran, Wei Zhang, Zhijie Dong, Xi Chen, Daniel A. Llano, Pengfei Song
bioRxiv 2021.06.04.447141; doi: https://doi.org/10.1101/2021.06.04.447141

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