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Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model

Andrew S. Mendiola, Kaira A. Church, Sandra M. Cardona, Difernando Vanegas, Shannon A. Garcia, Wendy Macklin, Sergio A. Lira, Richard M. Ransohoff, Erzsebet Kokovay, Chin-Hsing Annie Lin, Astrid E. Cardona
doi: https://doi.org/10.1101/2021.06.06.447262
Andrew S. Mendiola
1Gladstone Institutes, San Francisco, California, 94158, USA
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
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  • For correspondence: andrew.mendiola@gladstone.ucsf.edu
Kaira A. Church
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
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Sandra M. Cardona
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
3South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA
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Difernando Vanegas
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
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Shannon A. Garcia
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
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Wendy Macklin
4Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA
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Sergio A. Lira
5Precision Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
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Richard M. Ransohoff
6Third Rock Ventures, Boston, MA 02116, USA
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Erzsebet Kokovay
7Cell Systems and Anatomy, UT-Health Science Center San Antonio, San Antonio TX 78229, USA
8Barshop Institute of Longevity and Aging Studies, San Antonio, TX 78245, USA
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Chin-Hsing Annie Lin
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
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Astrid E. Cardona
2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
3South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA
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Article Information

doi 
https://doi.org/10.1101/2021.06.06.447262
History 
  • June 7, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. All rights reserved. No reuse allowed without permission.

Author Information

  1. Andrew S. Mendiola1,2,*,†,
  2. Kaira A. Church2,*,
  3. Sandra M. Cardona2,3,
  4. Difernando Vanegas2,
  5. Shannon A. Garcia2,
  6. Wendy Macklin4,
  7. Sergio A. Lira5,
  8. Richard M. Ransohoff6,
  9. Erzsebet Kokovay7,8,
  10. Chin-Hsing Annie Lin2 and
  11. Astrid E. Cardona2,3
  1. 1Gladstone Institutes, San Francisco, California, 94158, USA
  2. 2Department of Biology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
  3. 3South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, TX 78249, USA
  4. 4Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA
  5. 5Precision Immunology Institute Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  6. 6Third Rock Ventures, Boston, MA 02116, USA
  7. 7Cell Systems and Anatomy, UT-Health Science Center San Antonio, San Antonio TX 78229, USA
  8. 8Barshop Institute of Longevity and Aging Studies, San Antonio, TX 78245, USA
  1. ↵†Co-corresponding Authors: Email: andrew.mendiola{at}gladstone.ucsf.edu
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Posted June 07, 2021.
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Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model
Andrew S. Mendiola, Kaira A. Church, Sandra M. Cardona, Difernando Vanegas, Shannon A. Garcia, Wendy Macklin, Sergio A. Lira, Richard M. Ransohoff, Erzsebet Kokovay, Chin-Hsing Annie Lin, Astrid E. Cardona
bioRxiv 2021.06.06.447262; doi: https://doi.org/10.1101/2021.06.06.447262
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Microglial CX3CR1I249/M280 variant limits neurogenesis and remyelination in cuprizone-induced multiple sclerosis model
Andrew S. Mendiola, Kaira A. Church, Sandra M. Cardona, Difernando Vanegas, Shannon A. Garcia, Wendy Macklin, Sergio A. Lira, Richard M. Ransohoff, Erzsebet Kokovay, Chin-Hsing Annie Lin, Astrid E. Cardona
bioRxiv 2021.06.06.447262; doi: https://doi.org/10.1101/2021.06.06.447262

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