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Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
View ORCID ProfileFlorian Klemm, Alexander Schäffer, Anna Salamero-Boix, Tijna Alekseeva, Michael Schulz, Katja Niesel, Roeltje R. Maas, Marie Groth, Benelita T. Elie, Robert L. Bowman, Monika E. Hegi, Roy T. Daniel, Pia S. Zeiner, Jenny Zinke, Patrick N. Harter, Karl H. Plate, View ORCID ProfileJohanna A. Joyce, Lisa Sevenich
doi: https://doi.org/10.1101/2021.06.07.447034
Florian Klemm
1Department of Oncology, University of Lausanne, Lausanne, Switzerland
2Ludwig Institute for Cancer Research, Lausanne, Switzerland
Alexander Schäffer
3Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany
Anna Salamero-Boix
3Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany
4Biological Sciences, Faculty 15, Goethe University Frankfurt, Frankfurt am Main, Germany
Tijna Alekseeva
3Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany
Michael Schulz
3Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany
4Biological Sciences, Faculty 15, Goethe University Frankfurt, Frankfurt am Main, Germany
Katja Niesel
3Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany
Roeltje R. Maas
1Department of Oncology, University of Lausanne, Lausanne, Switzerland
2Ludwig Institute for Cancer Research, Lausanne, Switzerland
5Neuroscience Research Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
6Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Marie Groth
7Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Benelita T. Elie
7Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Robert L. Bowman
7Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Monika E. Hegi
5Neuroscience Research Center, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
6Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Roy T. Daniel
6Department of Neurosurgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
Pia S. Zeiner
8Institute of Neurology (Edinger Institute), Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
9Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt am Main, Germany
Jenny Zinke
8Institute of Neurology (Edinger Institute), Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
Patrick N. Harter
8Institute of Neurology (Edinger Institute), Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
10German Cancer Research Center (DKFZ), Heidelberg, Germany
11German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Germany
12Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany
Karl H. Plate
8Institute of Neurology (Edinger Institute), Goethe University Hospital Frankfurt, Frankfurt am Main, Germany
10German Cancer Research Center (DKFZ), Heidelberg, Germany
11German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Germany
12Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany
Johanna A. Joyce
1Department of Oncology, University of Lausanne, Lausanne, Switzerland
2Ludwig Institute for Cancer Research, Lausanne, Switzerland
Lisa Sevenich
3Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt am Main, Germany
10German Cancer Research Center (DKFZ), Heidelberg, Germany
11German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Germany
12Frankfurt Cancer Institute (FCI), Goethe University Frankfurt, Frankfurt am Main, Germany
Article usage
Posted June 07, 2021.
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
Florian Klemm, Alexander Schäffer, Anna Salamero-Boix, Tijna Alekseeva, Michael Schulz, Katja Niesel, Roeltje R. Maas, Marie Groth, Benelita T. Elie, Robert L. Bowman, Monika E. Hegi, Roy T. Daniel, Pia S. Zeiner, Jenny Zinke, Patrick N. Harter, Karl H. Plate, Johanna A. Joyce, Lisa Sevenich
bioRxiv 2021.06.07.447034; doi: https://doi.org/10.1101/2021.06.07.447034
Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis
Florian Klemm, Alexander Schäffer, Anna Salamero-Boix, Tijna Alekseeva, Michael Schulz, Katja Niesel, Roeltje R. Maas, Marie Groth, Benelita T. Elie, Robert L. Bowman, Monika E. Hegi, Roy T. Daniel, Pia S. Zeiner, Jenny Zinke, Patrick N. Harter, Karl H. Plate, Johanna A. Joyce, Lisa Sevenich
bioRxiv 2021.06.07.447034; doi: https://doi.org/10.1101/2021.06.07.447034
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