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Strain-Programmable Patch for Diabetic Wound Healing

Georgios Theocharidis, View ORCID ProfileHyunwoo Yuk, Heejung Roh, Liu Wang, Ikram Mezghani, Jingjing Wu, Antonios Kafanas, Lihong Chen, Chuan Fei Guo, Navin Jayaswal, Xanthi-Leda Katopodi, Christoph S. Nabzdyk, Ioannis S. Vlachos, Aristidis Veves, Xuanhe Zhao
doi: https://doi.org/10.1101/2021.06.07.447423
Georgios Theocharidis
1Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
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Hyunwoo Yuk
2Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
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  • For correspondence: hyunwoo@mit.edu aveves@bidmc.harvard.edu zhaox@mit.edu
Heejung Roh
2Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
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Liu Wang
2Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
3Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China
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Ikram Mezghani
1Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
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Jingjing Wu
2Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
3Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China
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Antonios Kafanas
4Lincoln County Hospital, Northern Lincolnshire and Goole NHS Foundation Trust, UK
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Lihong Chen
1Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
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Chuan Fei Guo
3Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China
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Navin Jayaswal
1Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
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Xanthi-Leda Katopodi
5Cancer Research Institute, HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
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Christoph S. Nabzdyk
6Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA
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Ioannis S. Vlachos
5Cancer Research Institute, HMS Initiative for RNA Medicine, Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
7Broad Institute of MIT and Harvard, Cambridge, MA, USA
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Aristidis Veves
1Joslin-Beth Israel Deaconess Foot Center and The Rongxiang Xu, MD, Center for Regenerative Therapeutics, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
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  • For correspondence: hyunwoo@mit.edu aveves@bidmc.harvard.edu zhaox@mit.edu
Xuanhe Zhao
2Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
8Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
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  • For correspondence: hyunwoo@mit.edu aveves@bidmc.harvard.edu zhaox@mit.edu
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ABSTRACT

Chronic wounds with impaired healing capability such as diabetic foot ulcers (DFU) are devastating complications in diabetic patients, inflicting rapidly growing clinical and economic burdens in aging societies. Despite recent advances in therapeutic approaches, limited benefits of the existing solutions highlight the critical need for novel therapeutic solutions for diabetic wound healing. Here we propose a strain-programmable patch capable of rapid robust adhesion on and programmable mechanical contraction of wet wounded tissues over days to offer a new therapeutic platform for diabetic wounds. The strain-programmable patch, consisting of a dried bioadhesive layer and a pre-stretched elastomer backing, implements a hydration-based shape-memory mechanism to achieve both uniaxial and biaxial contractions and stress remodeling of wet wounds in a programmable manner. We develop theoretical and numerical models to rationally guide the strain-programming and mechanical modulation of wounds. In vivo rodent and ex vivo human skin culture models validate the programmability and efficacy of the proposed platform and identify mechanisms of action for accelerated diabetic wound healing.

One Sentence Summary A strain-programmable bioadhesive patch is developed for accelerated closure and healing of wounds in diabetic mice and human skin.

Competing Interest Statement

The authors have declared no competing interest.

Footnotes

  • ↵† These authors jointly supervised this work.

Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
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Posted June 07, 2021.
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Strain-Programmable Patch for Diabetic Wound Healing
Georgios Theocharidis, Hyunwoo Yuk, Heejung Roh, Liu Wang, Ikram Mezghani, Jingjing Wu, Antonios Kafanas, Lihong Chen, Chuan Fei Guo, Navin Jayaswal, Xanthi-Leda Katopodi, Christoph S. Nabzdyk, Ioannis S. Vlachos, Aristidis Veves, Xuanhe Zhao
bioRxiv 2021.06.07.447423; doi: https://doi.org/10.1101/2021.06.07.447423
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Strain-Programmable Patch for Diabetic Wound Healing
Georgios Theocharidis, Hyunwoo Yuk, Heejung Roh, Liu Wang, Ikram Mezghani, Jingjing Wu, Antonios Kafanas, Lihong Chen, Chuan Fei Guo, Navin Jayaswal, Xanthi-Leda Katopodi, Christoph S. Nabzdyk, Ioannis S. Vlachos, Aristidis Veves, Xuanhe Zhao
bioRxiv 2021.06.07.447423; doi: https://doi.org/10.1101/2021.06.07.447423

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