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Brain charts for the human lifespan
View ORCID ProfileR.A.I. Bethlehem, View ORCID ProfileJ. Seidlitz, View ORCID ProfileS.R. White, J.W. Vogel, View ORCID ProfileK.M. Anderson, View ORCID ProfileC. Adamson, View ORCID ProfileS. Adler, View ORCID ProfileG.S. Alexopoulos, View ORCID ProfileE. Anagnostou, A. Areces-Gonzalez, View ORCID ProfileD.E. Astle, View ORCID ProfileB. Auyeung, View ORCID ProfileM. Ayub, View ORCID ProfileG. Ball, View ORCID ProfileS. Baron-Cohen, R. Beare, View ORCID ProfileS.A. Bedford, View ORCID ProfileV. Benegal, View ORCID ProfileF. Beyer, J. Bin Bae, J. Blangero, View ORCID ProfileM. Blesa Cábez, View ORCID ProfileJ.P. Boardman, View ORCID ProfileM. Borzage, View ORCID ProfileJ.F. Bosch-Bayard, View ORCID ProfileN. Bourke, View ORCID ProfileV.D. Calhoun, View ORCID ProfileM.M. Chakravarty, C. Chen, C. Chertavian, G. Chetelat, Y.S. Chong, View ORCID ProfileJ.H. Cole, A. Corvin, M. Costantino, E. Courchesne, View ORCID ProfileF. Crivello, View ORCID ProfileV.L. Cropley, View ORCID ProfileJ. Crosbie, N. Crossley, M. Delarue, R. Delorme, View ORCID ProfileS. Desrivieres, G. Devenyi, View ORCID ProfileM.A. Di Biase, View ORCID ProfileR. Dolan, View ORCID ProfileK.A. Donald, G. Donohoe, View ORCID ProfileK. Dunlop, View ORCID ProfileA.D. Edwards, J.T. Elison, C.T. Ellis, View ORCID ProfileJ.A. Elman, L. Eyler, D.A. Fair, View ORCID ProfileE. Feczko, P.C. Fletcher, View ORCID ProfileP. Fonagy, View ORCID ProfileC.E. Franz, View ORCID ProfileL. Galan-Garcia, View ORCID ProfileA. Gholipour, View ORCID ProfileJ. Giedd, J.H. Gilmore, View ORCID ProfileD.C. Glahn, View ORCID ProfileI. Goodyer, View ORCID ProfileP.E. Grant, View ORCID ProfileN.A. Groenewold, View ORCID ProfileF.M. Gunning, R.E. Gur, R.C. Gur, C.F. Hammill, O. Hansson, T. Hedden, View ORCID ProfileA. Heinz, View ORCID ProfileR.N. Henson, View ORCID ProfileK. Heuer, J. Hoare, B. Holla, View ORCID ProfileA.J. Holmes, R. Holt, View ORCID ProfileH. Huang, View ORCID ProfileK. Im, View ORCID ProfileJ. Ipser, View ORCID ProfileC.R. Jack Jr, View ORCID ProfileA.P. Jackowski, View ORCID ProfileT. Jia, View ORCID ProfileK.A. Johnson, View ORCID ProfileP.B. Jones, View ORCID ProfileD.T. Jones, R. Kahn, View ORCID ProfileH. Karlsson, View ORCID ProfileL. Karlsson, View ORCID ProfileR. Kawashima, View ORCID ProfileE.A. Kelley, View ORCID ProfileS. Kern, K. Kim, View ORCID ProfileM.G. Kitzbichler, View ORCID ProfileW.S. Kremen, F. Lalonde, View ORCID ProfileB. Landeau, S. Lee, J. Lerch, J.D. Lewis, View ORCID ProfileJ. Li, View ORCID ProfileW. Liao, View ORCID ProfileC. Liston, View ORCID ProfileM.V. Lombardo, View ORCID ProfileJ. Lv, View ORCID ProfileC. Lynch, View ORCID ProfileT.T. Mallard, M. Marcelis, R.D. Markello, S.R. Mathias, View ORCID ProfileB. Mazoyer, P. McGuire, M.J. Meaney, A. Mechelli, View ORCID ProfileN. Medic, B. Misic, S.E. Morgan, D. Mothersill, J. Nigg, View ORCID ProfileM.Q.W. Ong, View ORCID ProfileC. Ortinau, View ORCID ProfileR. Ossenkoppele, M. Ouyang, View ORCID ProfileL. Palaniyappan, L. Paly, View ORCID ProfileP.M. Pan, View ORCID ProfileC. Pantelis, View ORCID ProfileM.M. Park, View ORCID ProfileT. Paus, View ORCID ProfileZ. Pausova, View ORCID ProfileD. Paz-Linares, View ORCID ProfileA. Pichet Binette, K. Pierce, View ORCID ProfileX. Qian, View ORCID ProfileJ. Qiu, View ORCID ProfileA. Qiu, A. Raznahan, View ORCID ProfileT. Rittman, A. Rodrigue, View ORCID ProfileC.K. Rollins, R. Romero-Garcia, L. Ronan, View ORCID ProfileM.D. Rosenberg, View ORCID ProfileD.H. Rowitch, View ORCID ProfileG.A. Salum, View ORCID ProfileT.D. Satterthwaite, View ORCID ProfileH.L. Schaare, R.J. Schachar, View ORCID ProfileA.P. Schultz, G. Schumann, View ORCID ProfileM. Schöll, View ORCID ProfileD. Sharp, View ORCID ProfileR.T. Shinohara, View ORCID ProfileI. Skoog, C.D. Smyser, View ORCID ProfileR.A. Sperling, D.J. Stein, A. Stolicyn, J. Suckling, View ORCID ProfileG. Sullivan, View ORCID ProfileY. Taki, View ORCID ProfileB. Thyreau, View ORCID ProfileR. Toro, View ORCID ProfileN. Traut, View ORCID ProfileK.A. Tsvetanov, N.B. Turk-Browne, View ORCID ProfileJ.J. Tuulari, View ORCID ProfileC. Tzourio, É. Vachon-Presseau, View ORCID ProfileM.J. Valdes-Sosa, View ORCID ProfileP.A. Valdes-Sosa, S.L. Valk, T. van Amelsvoort, View ORCID ProfileS.N. Vandekar, L. Vasung, View ORCID ProfileL.W. Victoria, View ORCID ProfileS. Villeneuve, A. Villringer, P.E. Vértes, View ORCID ProfileK. Wagstyl, Y.S. Wang, View ORCID ProfileS.K. Warfield, View ORCID ProfileV. Warrier, View ORCID ProfileE. Westman, View ORCID ProfileM.L. Westwater, View ORCID ProfileH.C. Whalley, View ORCID ProfileA.V. Witte, N. Yang, View ORCID ProfileB. Yeo, H. Yun, View ORCID ProfileA. Zalesky, H.J. Zar, View ORCID ProfileA. Zettergren, View ORCID ProfileJ.H. Zhou, View ORCID ProfileH. Ziauddeen, View ORCID ProfileA. Zugman, View ORCID ProfileX.N. Zuo, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, UMN BCP, CALM Team, Cam-CAN, CCNP, COBRE, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA, View ORCID ProfileE.T. Bullmore, View ORCID ProfileA.F. Alexander-Bloch
doi: https://doi.org/10.1101/2021.06.08.447489
R.A.I. Bethlehem
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
2Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
J. Seidlitz
3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
4Department of Child and Adolescent Psychiatry and Behavioral Science, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104
S.R. White
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
6MRC Biostatistics Unit, University of Cambridge, Cambridge, England
J.W. Vogel
7Lifespan Informatics & Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104
3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
K.M. Anderson
8Department of Psychology, Yale University, New Haven, CT, USA
C. Adamson
9Developmental Imaging, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
10Department of Medicine, Monash University, Melbourne, Victoria, Australia
S. Adler
11UCL Great Ormond Street Institute for Child Health, 30 Guilford St, Holborn, London WC1N 1EH
G.S. Alexopoulos
12Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medicine
E. Anagnostou
13Department of Pediatrics University of Toronto
14Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada
A. Areces-Gonzalez
15The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, 611731, China
16University of Pinar del Río “Hermanos Saiz Montes de Oca”, Cuba
D.E. Astle
17MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge UK
B. Auyeung
18Department of Psychology, School of Philosophy, Psychology and Language Sciences, University of Edinburgh, Edinburgh, United Kingdom
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
M. Ayub
19University College London, Mental Health Neuroscience Research Department, Division of Psychiatry, London UK
G. Ball
9Developmental Imaging, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
20Department of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia
S. Baron-Cohen
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
21Cambridge Lifetime Asperger Syndrome Service (CLASS), Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, United Kingdom
R. Beare
9Developmental Imaging, Murdoch Children’s Research Institute, Melbourne, Victoria, Australia
10Department of Medicine, Monash University, Melbourne, Victoria, Australia
S.A. Bedford
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
V. Benegal
22Centre for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India 560029
F. Beyer
23Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, 04103, Germany
J. Bin Bae
24Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea
J. Blangero
25Department of Human Genetics, South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley
M. Blesa Cábez
26MRC Centre for Reproductive Health, University of Edinburgh, UK
J.P. Boardman
26MRC Centre for Reproductive Health, University of Edinburgh, UK
M. Borzage
27Fetal and Neonatal Institute, Division of Neonatology, Children’s Hospital Los Angeles, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California USA
J.F. Bosch-Bayard
28McGill Centre for Integrative Neuroscience, Ludmer Centre for Neuroinformatics and Mental Health, Montreal Neurological Institute
29McGill University
N. Bourke
30Department of Brain Sciences, Imperial College London, London UK & Care Research & Technology Centre, UK Dementia Research Institute
V.D. Calhoun
31Tri-institutional Center for Translational Research in Neuroimaging and Data Science, Georgia State University, Georgia Institute of Technology, and Emory University, Atlanta, GA, USA
M.M. Chakravarty
32Computational Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute
29McGill University
C. Chen
33Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
C. Chertavian
3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
G. Chetelat
34Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France
Y.S. Chong
35Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore
36Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J.H. Cole
37Centre for Medical Image Computing (CMIC), University College London
38Dementia Research Centre (DRC), University College London
A. Corvin
39Department of Psychiatry, Trinity College, Dublin, Ireland
M. Costantino
40Cerebral Imaging Centre, Douglas Mental Health University Institute, Verdun, Canada
41Undergraduate program in Neuroscience, McGill University, Montreal, Canada
E. Courchesne
42Department of Neuroscience, University of California, San Diego, San Diego, CA 92093, USA
43Autism Center of Excellence, University of California, San Diego, San Diego, CA 92037, USA
F. Crivello
44Institute of Neurodegenerative Disorders, CNRS UMR5293, University of Bordeaux
V.L. Cropley
45Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
J. Crosbie
46The Hospital for Sick Children, Toronto, Canada
N. Crossley
47Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Diagonal Paraguay 362, Santiago 8330077, Chile
48Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, De Crespigny Park, London SE5 8AF, UK
M. Delarue
34Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France
R. Delorme
49Child and Adolescent Psychiatry Department, Robert Debré University Hospital, AP-HP, F-75019, Paris France
50Human Genetics and Cognitive Functions, Institut Pasteur, F-75015, Paris France
S. Desrivieres
51Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom
G. Devenyi
52Cerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, QC, Canada
53Department of Psychiatry, McGill University, Montreal, QC, Canada
M.A. Di Biase
45Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
54Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, United States
R. Dolan
55Max Planck UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK
56Wellcome Centre for Human Neuroimaging, University College London, London, UK
K.A. Donald
57University of Cape Town, South Africa, Cape Town, South Africa
G. Donohoe
58Center for Neuroimaging, Cognition & Genomics (NICOG), School of Psychology, National University of Ireland Galway, Galway, Ireland
K. Dunlop
59Weil Family Brain and Mind Research Institute, Department of Psychiatry, Weill Cornell Medicine
A.D. Edwards
60Centre for the Developing Brain, King’s College London, London, UK
61Evelina London Children’s Hospital
J.T. Elison
62Institute of Child Development, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States
C.T. Ellis
8Department of Psychology, Yale University, New Haven, CT, USA
J.A. Elman
63Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA
L. Eyler
64Desert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare, San Diego, CA, USA
65Department of Psychiatry, University of California San Diego, Los Angeles, CA, USA
D.A. Fair
62Institute of Child Development, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States
E. Feczko
62Institute of Child Development, Department of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, United States
P.C. Fletcher
66Department of Psychiatry, University of Cambridge, and Wellcome Trust MRC Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom
67Cambridgeshire and Peterborough NHS Foundation Trust
P. Fonagy
68Department of Clinical, Educational and Health Psychology, University College London, London, UK
C.E. Franz
69Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA 92093
L. Galan-Garcia
70Cuban Center for Neuroscience, La Habana, Cuba
A. Gholipour
71Computational Radiology Laboratory, Boston Children’s Hospital, Boston, MA 02115
J. Giedd
72Department of Child and Adolescent Psychiatry, University of California, San Diego, San Diego, CA 92093, USA
73Department of Psychiatry, University of California San Diego, San Diego, CA, USA
J.H. Gilmore
74Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
D.C. Glahn
75Department of Psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115
76Harvard Medical School, Boston, MA 02115
I. Goodyer
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
P.E. Grant
77Division of Newborn Medicine and Neuroradiology, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
N.A. Groenewold
78Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, South Africa
79Neuroscience Institute, University of Cape Town, Cape Town, South Africa
F.M. Gunning
12Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medicine
R.E. Gur
3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
80Lifespan Brain Institute, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104
R.C. Gur
3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
81Lifespan Brain Institute, The Children’s Hospital of Philadelphia, Philadelphia, PA 19105
C.F. Hammill
46The Hospital for Sick Children, Toronto, Canada
82Mouse Imaging Centre, Toronto, Canada
O. Hansson
83Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden
84Memory Clinic, Skåne University Hospital, Malmö, Sweden
T. Hedden
85Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
86Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
A. Heinz
87Department of Psychiatry and Psychotherapy, Charite University Hospital Berlin, Berlin, Germany
R.N. Henson
17MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge UK
88Department of Psychiatry, University of Cambridge, Cambridge, UK
K. Heuer
89Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
90Université de Paris, Paris, France
J. Hoare
91Department of Psychiatry, University of Cape Town, Cape Town, South Africa
B. Holla
92Departments of Psychiatry and Integrative Medicine, NIMHANS, Bengaluru, India
A.J. Holmes
93Departments of Psychology and Psychiatry, Yale University, New Haven, CT, USA
R. Holt
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
H. Huang
94Radiology Research, Children’s Hospital of Philadelphia, Philadelphia, United States
95The Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States
K. Im
96Division of Newborn Medicine, Fetal Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
97Boston Children’s Hospital, Boston, MA 02115
J. Ipser
98Department of Psychiatry and Mental Health, Clinical Neuroscience Institute, University of Cape Town
C.R. Jack Jr
99Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA
A.P. Jackowski
100Department of Psychiatry, Universidade Federal de São Paulo
101National Institute of Developmental Psychiatry, CNPq
T. Jia
102Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200433, China
103Key Laboratory of Computational Neuroscience and BrainInspired Intelligence (Fudan University), Ministry of Education, Shanghai, China
104Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology and Neuroscience, SGDP Centre, King’s College London, London SE5 8AF, UK
K.A. Johnson
105Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114
106Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115
76Harvard Medical School, Boston, MA 02115
107Department of Radiology, Massachusetts General Hospital, Boston, MA
P.B. Jones
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
108Cambridgeshire and Peterborough NHS Foundation Trust, Huntingdon, United Kingdom
D.T. Jones
109Department of Neurology, Mayo Clinic, Rochester, MN, USA
110Department of Radiology, Mayo Clinic, Rochester, MN, USA
R. Kahn
111Department of Psychiatry Division of Neurosciences, University Medical Center, Utrecht, The Netherlands
112Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, USA
H. Karlsson
113Department of Clinical Medicine, Department of Psychiatry and Turku Brain and Mind Center, FinnBrain Birth Cohort Study, University of Turku and Turku University Hospital, Turku, Finland
114Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland
L. Karlsson
113Department of Clinical Medicine, Department of Psychiatry and Turku Brain and Mind Center, FinnBrain Birth Cohort Study, University of Turku and Turku University Hospital, Turku, Finland
114Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland
R. Kawashima
115Institute of Development, Aging and Cancer, Tohoku University, Seiryocho, Aobaku, Sendai 980-8575, Japan
E.A. Kelley
116Queen’s University, Departments of Psychology and Psychiatry, Centre for Neuroscience Studies, Kingston, Ontario, Canada
S. Kern
117Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
K. Kim
118Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea
119Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
120Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea
121Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences
M.G. Kitzbichler
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
W.S. Kremen
63Department of Psychiatry, Center for Behavior Genetics of Aging, University of California, San Diego, La Jolla, CA
F. Lalonde
122Section on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD, USA
B. Landeau
34Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France
S. Lee
123Department of Brain & Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Korea
J. Lerch
124Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
125Mouse Imaging Centre, The Hospital for Sick Children, Toronto, ON, Canada
126Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK
J.D. Lewis
127Montreal Neurological Institute, McGill University, Montreal, Canada
J. Li
128The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 611731, China
W. Liao
128The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu 611731, China
C. Liston
129Department of Psychiatry and Brain and Mind Research Institute, Weill Cornell Medicine
M.V. Lombardo
130Laboratory for Autism and Neurodevelopmental Disorders, Center for Neuroscience and Cognitive Systems @UniTn, Istituto Italiano di Tecnologia, Rovereto, Italy
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
J. Lv
45Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia
131School of Biomedical Engineering & Brain and Mind Centre, The University of Sydney, Sydney, NSW, Australia
C. Lynch
59Weil Family Brain and Mind Research Institute, Department of Psychiatry, Weill Cornell Medicine
T.T. Mallard
132Department of Psychology, University of Texas, Austin, Texas 78712, USA
M. Marcelis
133Department of Psychiatry and Neuropsychology, School of Mental Health and Neuroscience, EURON, Maastricht University Medical Centre, PO Box 616, 6200 MD, Maastricht, the Netherlands; Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, the Netherlands
R.D. Markello
134McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
S.R. Mathias
75Department of Psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115
B. Mazoyer
44Institute of Neurodegenerative Disorders, CNRS UMR5293, University of Bordeaux
135Bordeaux University Hospital
P. McGuire
136Professor, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
M.J. Meaney
137Ludmer Centre for Neuroinformatics and Mental Health, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada; Singapore Institute for Clinical Sciences, Singapore
A. Mechelli
136Professor, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, UK
N. Medic
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
B. Misic
134McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada
S.E. Morgan
138Department of Computer Science and Technology, University of Cambridge, Cambridge CB3 0FD, United Kingdom
139Department of Psychiatry, University of Cambridge, Cambridge CB2 0SZ, United Kingdom
140The Alan Turing Institute, London, NW1 2DB
D. Mothersill
141Department of Psychology, School of Business, National College of Ireland, Dublin, Ireland
142School of Psychology & Center for Neuroimaging and Cognitive Genomics, National University of Ireland Galway, Galway, Ireland
143Department of Psychiatry, Trinity College Dublin, Dublin, Ireland
J. Nigg
144Department of Psychiatry, School of Medicine, Oregon Health and Science University, Portland, United States
M.Q.W. Ong
145Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
C. Ortinau
146Department of Pediatrics, Washington University in St. Louis, St. Louis, Missouri, United States
R. Ossenkoppele
147Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands
148Lund University, Clinical Memory Research Unit, Lund, Sweden
M. Ouyang
94Radiology Research, Children’s Hospital of Philadelphia, Philadelphia, United States
L. Palaniyappan
149Robarts Research Institute & The Brain and Mind Institute, University of Western Ontario,London,Ontario,Canada
L. Paly
34Normandie Univ, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders”, Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France
P.M. Pan
150Department of Psychiatry, Federal University of Sao Poalo (UNIFESP)
151National Institute of Developmental Psychiatry for Children and Adolescents (INPD), Brazil
C. Pantelis
152Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia
153Melbourne School of Engineering, The University of Melbourne, Parkville, Victoria, Australia
154Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia
M.M. Park
155Department of Psychiatry, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada
T. Paus
156Department of Psychiatry, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, Quebec, Canada
157Departments of Psychiatry and Psychology, University of Toronto, Toronto, ON, Canada
Z. Pausova
46The Hospital for Sick Children, Toronto, Canada
158Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada
D. Paz-Linares
15The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for NeuroInformation, University of Electronic Science and Technology of China, No. 2006, Xiyuan Ave., West Hi-Tech Zone, Chengdu, 611731, China
159Cuban Neuroscience Center, Havana, Cuba
A. Pichet Binette
160Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Qc, H3A 1Y2, Canada
161Douglas Mental Health University Institute, Montreal, Qc, H4H 1R3, Canada
K. Pierce
162Autism Center of Excellence, Department of Neurosciences, University of California, San Diego La Jolla, CA, USA
X. Qian
145Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
J. Qiu
163School of Psychology, Southwest University, Chongqing 400715, P.R. China
A. Qiu
164Department of Biomedical Engineering, The N.1 Institute for Health, National University of Singapore
A. Raznahan
122Section on Developmental Neurogenomics, Human Genetics Branch, National Institute of Mental Health, Bethesda, MD, USA
T. Rittman
165Department of Clinical Neurosciences, University of Cambridge, Cambridge UK
A. Rodrigue
75Department of Psychiatry, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115
C.K. Rollins
166Department of Neurology, Harvard Medical School
167Department of Neurology, Boston Children’s Hospital, Boston, MA 02115
R. Romero-Garcia
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
168Instituto de Biomedicina de Sevilla (IBiS) HUVR/CSIC/Universidad de Sevilla, Dpto. de Fisiología Médica y Biofísica, Spain
L. Ronan
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
M.D. Rosenberg
169Department of Psychology, Neuroscience Institute, University of Chicago
D.H. Rowitch
170Department of Paediatrics and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Hills Road, Cambridge, UK
G.A. Salum
171Department of Psychiatry, Universidade Federal do Rio Grande do Sul (UFRGS)
172National Institute of Developmental Psychiatry (INPD)
T.D. Satterthwaite
7Lifespan Informatics & Neuroimaging Center, University of Pennsylvania, Philadelphia, PA 19104
3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
H.L. Schaare
173Otto Hahn Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
174Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Juelich, Juelich, Germany
R.J. Schachar
46The Hospital for Sick Children, Toronto, Canada
A.P. Schultz
105Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114
175Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA
76Harvard Medical School, Boston, MA 02115
G. Schumann
176Centre for Population Neuroscience and Stratified Medicine (PONS), SGDP Centre, IoPPN, KCL, UK
177PONS-Centre, Dept of Psychiatry and Psychotherapy, Campus Charite Mitte, Humboldt University, Berlin, Germany
178PONS Centre, Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China
M. Schöll
179Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
180Department of Psychiatry and Neurochemistry, University of Gothenburg, Sweden
181Dementia Research Centre, Queen’s Square Institute of Neurology, University College London, UK
D. Sharp
30Department of Brain Sciences, Imperial College London, London UK & Care Research & Technology Centre, UK Dementia Research Institute
R.T. Shinohara
33Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
182Center for Biomedical Image Computing and Analytics, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
I. Skoog
117Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
C.D. Smyser
183Departments of Neurology, Pediatrics, and Radiology, Washington University School of Medicine, St. Louis, United States
R.A. Sperling
105Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114
106Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women’s Hospital, Boston, MA 02115
76Harvard Medical School, Boston, MA 02115
D.J. Stein
184SA MRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa
A. Stolicyn
185Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK
J. Suckling
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
G. Sullivan
26MRC Centre for Reproductive Health, University of Edinburgh, UK
Y. Taki
115Institute of Development, Aging and Cancer, Tohoku University, Seiryocho, Aobaku, Sendai 980-8575, Japan
B. Thyreau
115Institute of Development, Aging and Cancer, Tohoku University, Seiryocho, Aobaku, Sendai 980-8575, Japan
R. Toro
186Department of Neuroscience, Institut Pasteur, Paris, France
90Université de Paris, Paris, France
N. Traut
186Department of Neuroscience, Institut Pasteur, Paris, France
187Center for Research and Interdisciplinarity (CRI), Université Paris Descartes, Paris, France
K.A. Tsvetanov
165Department of Clinical Neurosciences, University of Cambridge, Cambridge UK
188Department of Psychology, University of Cambridge, Cambridge, UK
N.B. Turk-Browne
8Department of Psychology, Yale University, New Haven, CT, USA
189Wu Tsai Institute, Yale University, New Haven, CT, USA
J.J. Tuulari
190Department of Clinical Medicine, Department of Psychiatry, FinnBrain Birth Cohort Study, University of Turku, Turku, Finland
191Department of Clinical Medicine, University of Turku, Turku Finland
192Turku Collegium for Science, Medicine and Technology, University of Turku, Turku, Finland
C. Tzourio
193Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, U1219, CHU Bordeaux, F-33000 Bordeaux, France
É. Vachon-Presseau
194Department of Anesthesia, Faculty of Medicine, McGill University, Montreal, Qc, H3A 1G1, Canada
195Faculty of Dentistry, McGill University, Montreal, Qc, H3A 1G1, Canada
196Alan Edwards Centre for Research on Pain (AECRP), McGill University, Montreal, Qc, H3A 1G1, Canada
M.J. Valdes-Sosa
70Cuban Center for Neuroscience, La Habana, Cuba
P.A. Valdes-Sosa
197Joint China-Cuba Lab,University of Electronic Science and Technology, Chengdu China/Cuban Center for Neuroscience, La Habana, Cuba
198University of Electronic Science and Technology of China/Cuban Center for Neuroscience
S.L. Valk
199Institute for Neuroscience and Medicine 7, Forschungszentrum Juelich; Max Planck Institute for Human Cognitive and Brain Sciences
T. van Amelsvoort
200Department of Psychiatry & Neurosychology, Maastricht University, Maastricht, The Netherlands
S.N. Vandekar
201Department of Biostatistics, Vanderbilt University, Nashville, Tennessee, USA
202Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
L. Vasung
203Division of Newborn Medicine, Fetal Neonatal Neuroimaging and Developmental Science Center, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115
L.W. Victoria
12Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medicine
S. Villeneuve
161Douglas Mental Health University Institute, Montreal, Qc, H4H 1R3, Canada
204McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
160Department of Psychiatry, Faculty of Medicine, McGill University, Montreal, Qc, H3A 1Y2, Canada
A. Villringer
23Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, 04103, Germany
205Clinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, 04103, Germany
P.E. Vértes
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
206The Alan Turing Institute, London NW1 2DB, UK
K. Wagstyl
207Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, WC1N 3AR
Y.S. Wang
208State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
209Developmental Population Neuroscience Research Center, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
210National Basic Science Data Center, Beijing 100190, China
211Research Center for Lifespan Development of Brain and Mind, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
S.K. Warfield
71Computational Radiology Laboratory, Boston Children’s Hospital, Boston, MA 02115
V. Warrier
1Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
E. Westman
212Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
M.L. Westwater
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
H.C. Whalley
185Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK
A.V. Witte
205Clinic for Cognitive Neurology, University of Leipzig Medical Center, Leipzig, 04103, Germany
23Department of Neurology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, 04103, Germany
213Faculty of Medicine, CRC 1052 ‘Obesity Mechanisms’, University of Leipzig, Leipzig, 04103, Germany
N. Yang
208State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
209Developmental Population Neuroscience Research Center, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
210National Basic Science Data Center, Beijing 100190, China
211Research Center for Lifespan Development of Brain and Mind, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
B. Yeo
214Department of Electrical and Computer Engineering, National University of Singapore, Singapore
215Centre for Sleep & Cognition and Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
216N.1 Institute for Health & Institute for Digital Medicine, National University of Singapore, Singapore
217Integrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore
H. Yun
218Fetal Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USA
A. Zalesky
219Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Australia; Department of Biomedical Engineering, University of Melbourne, Melbourne, Australia
H.J. Zar
78Department of Paediatrics and Child Health, Red Cross War Memorial Children’s Hospital, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, South Africa
220SAMRC Unit on Child & Adolescent Health, University of Cape Town, South Africa
A. Zettergren
117Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
J.H. Zhou
145Center for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
221Center for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
214Department of Electrical and Computer Engineering, National University of Singapore, Singapore
H. Ziauddeen
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
222Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 0SZ
223Cambridgeshire and Peterborough Foundation Trust, Cambridge, CB21 5EF
A. Zugman
224National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Bethesda, Maryland, USA
225Department of Psychiatry, Escola Paulista de Medicina, São Paulo, Brazil
X.N. Zuo
208State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China
209Developmental Population Neuroscience Research Center, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China
210National Basic Science Data Center, Beijing 100190, China
211Research Center for Lifespan Development of Brain and Mind, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China
226Key Laboratory of Brain and Education, School of Education Science, Nanning Normal University, Nanning 530001, China
E.T. Bullmore
5Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK
A.F. Alexander-Bloch
3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104
4Department of Child and Adolescent Psychiatry and Behavioral Science, The Children’s Hospital of Philadelphia, Philadelphia, PA 19104
Abstract
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight1. Here, we built an interactive resource to benchmark brain morphology, www.brainchart.io, derived from any current or future sample of magnetic resonance imaging (MRI) data. With the goal of basing these reference charts on the largest and most inclusive dataset available, we aggregated 123,984 MRI scans from 101,457 participants aged from 115 days post-conception through 100 postnatal years, across more than 100 primary research studies. Cerebrum tissue volumes and other global or regional MRI metrics were quantified by centile scores, relative to non-linear trajectories2 of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones3; showed high stability of individual centile scores over longitudinal assessments; and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared to non-centiled MRI phenotypes, and provided a standardised measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In sum, brain charts are an essential first step towards robust quantification of individual deviations from normative trajectories in multiple, commonly-used neuroimaging phenotypes. Our collaborative study proves the principle that brain charts are achievable on a global scale over the entire lifespan, and applicable to analysis of diverse developmental and clinical effects on human brain structure. Furthermore, we provide open resources to support future advances towards adoption of brain charts as standards for quantitative benchmarking of typical or atypical brain MRI scans.
Competing Interest Statement
The authors have declared no competing interest.
Footnotes
↵† jointly supervised the work
↵* Data used in this article were obtained from the brain consortium for reproducibility, reliability and replicability (3R-BRAIN).
↵** Data used in the preparation of this article was obtained from the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL) funded by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) which was made available at the ADNI database (www.loni.usc.edu/ADNI). The AIBL researchers contributed data but did not participate in analysis or writing of this report. AIBL researchers are listed at www.aibl.csiro.au.
↵*** Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf
↵**** A complete listing of ARWiBo researchers can be found online.
↵***** Data used in this article were collected and processed by the UMN Baby Connectome Project (BCP) consortium and the Masonic Institute for the Developing Brain (MIDB) Informatics group. The groups are comprised of the following individuals: Amanda Ruetger, Audrey Houghton, Ben Lynch, Thomas Pengo, Jim Wilgenbusch, Tim Hendrickson, Trevor Day, Sooyeon Sung, Kathy Snider, Lucille Moore, Alice Graham, Damien Fair, Eric Feczko and Jed Elison
↵****** The Centre for Attention Learning and Memory (CALM) research clinic is based at and supported by funding from the Medical Research Council Cognition and Brain Sciences Unit, University of Cambridge, as well as funding from the EU Horizon 2020 Personalised Medicine “LifeBrain” project (H2020-SC1-2016-2017, Topic SC1-PM-04-2016). The lead investigators are Duncan Astle, Kate Baker, Susan E. Gathercole, Joni Holmes, Rogier A. Kievit, and Tom Manly. Data collection was assisted by a team of researchers and PhD students that includes Danyla Akarca, Joe Bathelt,Giacomo Bignardi, Sarah Bishop, Erica Botanic, Lara Bridge, Diandra Bkric, Annie Bryant, Sally Butterfield, Elizabeth Byrne, Gemma Crickmore, Edwin Dalmaijer; Fánchea Daly, Tina Emery, Grace Franckel, Laura Forde, Delia Fuhrmann, Andrew Gadie, Sara Gharooni, Jacalyn Guy, Erin Hawkins, Agniezska Jaroslawska, Sara Joeghan, Amy Johnson, Jonathan Jones, Elise Ng-Cordell, Sinéad O’Brien, Cliodhna O’Leary, Joseph Rennie, Ivan Simpson-Kent, Roma Siugzdaite, Tess Smith, Stepheni Uh, Francesca Woolgar, Mengya Zhang, and Natalia Zdorovtsova. We thank the many professionals working in children’s services in the southeast and east of England for their support and to the children and their families for giving up their time to visit the clinic, and to the radiographers for facilitating pediatric scanning.
↵******* The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) research was supported by the Biotechnology and Biological Sciences Research Council (BB/H008217/1), as well as funding from the Medical Research Council Cognition and Brain Sciences Unit, and the EU Horizon 2020 Personalised Medicine “LifeBrain” project (H2020-SC1-2016-2017, Topic SC1-PM-04-2016). We thank the Cam-CAN respondents and their primary care teams in Cambridge for their participation in this study. Further information about the Cam-CAN corporate authorship membership can be found at http://www.cam-can.org/index.php?content=corpauth#12.
↵******** Data used in this article were obtained from the developmental component ‘Growing Up in China’ of Chinese Color Nest Project (http://deepneuro.bnu.edu.cn/?p=163).
↵********* Data was downloaded from the COllaborative Informatics and Neuroimaging Suite Data Exchange tool (COINS; http://coins.mrn.org/dx) and data collection was performed at the Mind Research Network, and funded by a Center of Biomedical Research Excellence (COBRE) grant 5P20RR021938/P20GM103472 from the NIH to Dr. Vince Calhoun.
↵********** The ENIGMA Developmental Brain Age working group principally consists of Drs. James Cole, Niall Bourke, Heather Whalley, David Glahn, Laura Han, Francesca Biondo, Katherine Karlsgodt, Carrie Bearden, Jakob Seidlitz, Richard Bethlehem, Eileen Xu, Marieke Bos, Sam Mathia, Sophia Frangou, Miruna Carmen Barbu, Yoonho Chung, and Aaron Alexander-Bloch
↵*********** Data used in the preparation of this article were obtained from the Harvard Aging Brain Study (HABS - P01AG036694; https://habs.mgh.harvard.edu). The HABS study was launched in 2010, funded by the National Institute on Aging. and is led by principal investigators Reisa A. Sperling MD and Keith A. Johnson MD at Massachusetts General Hospital/Harvard Medical School in Boston, MA.
↵************ Data used in the preparation of this article were obtained from the IMAGEN consortium.
↵************* Data used in this article were obtained from the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD) (https://recode.re.kr).
↵************** A full list of NSPN consortium members can be found at: https://www.nspn.org.uk/nspn-team/
↵*************** The POND network is a Canadian translational network in neurodevelopmental disorders, primarily funded by the Ontario Brain Institute.
Extensive new analyses to include QC, harmonisation, increased validation of out of sample estimation and regional specifity
Copyright
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license.
Posted January 13, 2022.
Brain charts for the human lifespan
R.A.I. Bethlehem, J. Seidlitz, S.R. White, J.W. Vogel, K.M. Anderson, C. Adamson, S. Adler, G.S. Alexopoulos, E. Anagnostou, A. Areces-Gonzalez, D.E. Astle, B. Auyeung, M. Ayub, G. Ball, S. Baron-Cohen, R. Beare, S.A. Bedford, V. Benegal, F. Beyer, J. Bin Bae, J. Blangero, M. Blesa Cábez, J.P. Boardman, M. Borzage, J.F. Bosch-Bayard, N. Bourke, V.D. Calhoun, M.M. Chakravarty, C. Chen, C. Chertavian, G. Chetelat, Y.S. Chong, J.H. Cole, A. Corvin, M. Costantino, E. Courchesne, F. Crivello, V.L. Cropley, J. Crosbie, N. Crossley, M. Delarue, R. Delorme, S. Desrivieres, G. Devenyi, M.A. Di Biase, R. Dolan, K.A. Donald, G. Donohoe, K. Dunlop, A.D. Edwards, J.T. Elison, C.T. Ellis, J.A. Elman, L. Eyler, D.A. Fair, E. Feczko, P.C. Fletcher, P. Fonagy, C.E. Franz, L. Galan-Garcia, A. Gholipour, J. Giedd, J.H. Gilmore, D.C. Glahn, I. Goodyer, P.E. Grant, N.A. Groenewold, F.M. Gunning, R.E. Gur, R.C. Gur, C.F. Hammill, O. Hansson, T. Hedden, A. Heinz, R.N. Henson, K. Heuer, J. Hoare, B. Holla, A.J. Holmes, R. Holt, H. Huang, K. Im, J. Ipser, C.R. Jack Jr, A.P. Jackowski, T. Jia, K.A. Johnson, P.B. Jones, D.T. Jones, R. Kahn, H. Karlsson, L. Karlsson, R. Kawashima, E.A. Kelley, S. Kern, K. Kim, M.G. Kitzbichler, W.S. Kremen, F. Lalonde, B. Landeau, S. Lee, J. Lerch, J.D. Lewis, J. Li, W. Liao, C. Liston, M.V. Lombardo, J. Lv, C. Lynch, T.T. Mallard, M. Marcelis, R.D. Markello, S.R. Mathias, B. Mazoyer, P. McGuire, M.J. Meaney, A. Mechelli, N. Medic, B. Misic, S.E. Morgan, D. Mothersill, J. Nigg, M.Q.W. Ong, C. Ortinau, R. Ossenkoppele, M. Ouyang, L. Palaniyappan, L. Paly, P.M. Pan, C. Pantelis, M.M. Park, T. Paus, Z. Pausova, D. Paz-Linares, A. Pichet Binette, K. Pierce, X. Qian, J. Qiu, A. Qiu, A. Raznahan, T. Rittman, A. Rodrigue, C.K. Rollins, R. Romero-Garcia, L. Ronan, M.D. Rosenberg, D.H. Rowitch, G.A. Salum, T.D. Satterthwaite, H.L. Schaare, R.J. Schachar, A.P. Schultz, G. Schumann, M. Schöll, D. Sharp, R.T. Shinohara, I. Skoog, C.D. Smyser, R.A. Sperling, D.J. Stein, A. Stolicyn, J. Suckling, G. Sullivan, Y. Taki, B. Thyreau, R. Toro, N. Traut, K.A. Tsvetanov, N.B. Turk-Browne, J.J. Tuulari, C. Tzourio, É. Vachon-Presseau, M.J. Valdes-Sosa, P.A. Valdes-Sosa, S.L. Valk, T. van Amelsvoort, S.N. Vandekar, L. Vasung, L.W. Victoria, S. Villeneuve, A. Villringer, P.E. Vértes, K. Wagstyl, Y.S. Wang, S.K. Warfield, V. Warrier, E. Westman, M.L. Westwater, H.C. Whalley, A.V. Witte, N. Yang, B. Yeo, H. Yun, A. Zalesky, H.J. Zar, A. Zettergren, J.H. Zhou, H. Ziauddeen, A. Zugman, X.N. Zuo, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, UMN BCP, CALM Team, Cam-CAN, CCNP, COBRE, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA, E.T. Bullmore, A.F. Alexander-Bloch
bioRxiv 2021.06.08.447489; doi: https://doi.org/10.1101/2021.06.08.447489
Brain charts for the human lifespan
R.A.I. Bethlehem, J. Seidlitz, S.R. White, J.W. Vogel, K.M. Anderson, C. Adamson, S. Adler, G.S. Alexopoulos, E. Anagnostou, A. Areces-Gonzalez, D.E. Astle, B. Auyeung, M. Ayub, G. Ball, S. Baron-Cohen, R. Beare, S.A. Bedford, V. Benegal, F. Beyer, J. Bin Bae, J. Blangero, M. Blesa Cábez, J.P. Boardman, M. Borzage, J.F. Bosch-Bayard, N. Bourke, V.D. Calhoun, M.M. Chakravarty, C. Chen, C. Chertavian, G. Chetelat, Y.S. Chong, J.H. Cole, A. Corvin, M. Costantino, E. Courchesne, F. Crivello, V.L. Cropley, J. Crosbie, N. Crossley, M. Delarue, R. Delorme, S. Desrivieres, G. Devenyi, M.A. Di Biase, R. Dolan, K.A. Donald, G. Donohoe, K. Dunlop, A.D. Edwards, J.T. Elison, C.T. Ellis, J.A. Elman, L. Eyler, D.A. Fair, E. Feczko, P.C. Fletcher, P. Fonagy, C.E. Franz, L. Galan-Garcia, A. Gholipour, J. Giedd, J.H. Gilmore, D.C. Glahn, I. Goodyer, P.E. Grant, N.A. Groenewold, F.M. Gunning, R.E. Gur, R.C. Gur, C.F. Hammill, O. Hansson, T. Hedden, A. Heinz, R.N. Henson, K. Heuer, J. Hoare, B. Holla, A.J. Holmes, R. Holt, H. Huang, K. Im, J. Ipser, C.R. Jack Jr, A.P. Jackowski, T. Jia, K.A. Johnson, P.B. Jones, D.T. Jones, R. Kahn, H. Karlsson, L. Karlsson, R. Kawashima, E.A. Kelley, S. Kern, K. Kim, M.G. Kitzbichler, W.S. Kremen, F. Lalonde, B. Landeau, S. Lee, J. Lerch, J.D. Lewis, J. Li, W. Liao, C. Liston, M.V. Lombardo, J. Lv, C. Lynch, T.T. Mallard, M. Marcelis, R.D. Markello, S.R. Mathias, B. Mazoyer, P. McGuire, M.J. Meaney, A. Mechelli, N. Medic, B. Misic, S.E. Morgan, D. Mothersill, J. Nigg, M.Q.W. Ong, C. Ortinau, R. Ossenkoppele, M. Ouyang, L. Palaniyappan, L. Paly, P.M. Pan, C. Pantelis, M.M. Park, T. Paus, Z. Pausova, D. Paz-Linares, A. Pichet Binette, K. Pierce, X. Qian, J. Qiu, A. Qiu, A. Raznahan, T. Rittman, A. Rodrigue, C.K. Rollins, R. Romero-Garcia, L. Ronan, M.D. Rosenberg, D.H. Rowitch, G.A. Salum, T.D. Satterthwaite, H.L. Schaare, R.J. Schachar, A.P. Schultz, G. Schumann, M. Schöll, D. Sharp, R.T. Shinohara, I. Skoog, C.D. Smyser, R.A. Sperling, D.J. Stein, A. Stolicyn, J. Suckling, G. Sullivan, Y. Taki, B. Thyreau, R. Toro, N. Traut, K.A. Tsvetanov, N.B. Turk-Browne, J.J. Tuulari, C. Tzourio, É. Vachon-Presseau, M.J. Valdes-Sosa, P.A. Valdes-Sosa, S.L. Valk, T. van Amelsvoort, S.N. Vandekar, L. Vasung, L.W. Victoria, S. Villeneuve, A. Villringer, P.E. Vértes, K. Wagstyl, Y.S. Wang, S.K. Warfield, V. Warrier, E. Westman, M.L. Westwater, H.C. Whalley, A.V. Witte, N. Yang, B. Yeo, H. Yun, A. Zalesky, H.J. Zar, A. Zettergren, J.H. Zhou, H. Ziauddeen, A. Zugman, X.N. Zuo, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, UMN BCP, CALM Team, Cam-CAN, CCNP, COBRE, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA, E.T. Bullmore, A.F. Alexander-Bloch
bioRxiv 2021.06.08.447489; doi: https://doi.org/10.1101/2021.06.08.447489
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