Multiscale mechanistic modelling of the host defense in invasive aspergillosis reveals leukocyte activation and iron acquisition as drivers of infection outcome

Henrique AL Ribeiro; Luis Sordo Vieira; Yogesh Scindia; Bandita Adhikari; Matthew Wheeler; Adam Knapp; William Schroeder; Borna Mehrad; Reinhard Laubenbacher

doi:10.1101/2021.06.08.447590

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Multiscale mechanistic modelling of the host defense in invasive aspergillosis reveals leukocyte activation and iron acquisition as drivers of infection outcome

Henrique AL Ribeiro, View ORCID ProfileLuis Sordo Vieira, Yogesh Scindia, Bandita Adhikari, Matthew Wheeler, View ORCID ProfileAdam Knapp, William Schroeder, Borna Mehrad, View ORCID ProfileReinhard Laubenbacher

doi: https://doi.org/10.1101/2021.06.08.447590

Henrique AL Ribeiro

1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA

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Luis Sordo Vieira

1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA

2Department of Psychiatry, University of Florida, Gainesville, FL, USA

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ORCID record for Luis Sordo Vieira

Yogesh Scindia

1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA

5Department of Pathology, University of Florida, Gainesville, FL, USA

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Bandita Adhikari

3Center for Quantitative Medicine, School of Medicine, University of Connecticut, Farmington, CT, USA

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Matthew Wheeler

1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA

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Adam Knapp

1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA

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ORCID record for Adam Knapp

William Schroeder

4Kitware Inc., Clifton Park, NY, USA

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Borna Mehrad

1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA

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Reinhard Laubenbacher

1Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA

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ORCID record for Reinhard Laubenbacher

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Posted November 01, 2021.

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Multiscale mechanistic modelling of the host defense in invasive aspergillosis reveals leukocyte activation and iron acquisition as drivers of infection outcome

Henrique AL Ribeiro, Luis Sordo Vieira, Yogesh Scindia, Bandita Adhikari, Matthew Wheeler, Adam Knapp, William Schroeder, Borna Mehrad, Reinhard Laubenbacher

bioRxiv 2021.06.08.447590; doi: https://doi.org/10.1101/2021.06.08.447590

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Multiscale mechanistic modelling of the host defense in invasive aspergillosis reveals leukocyte activation and iron acquisition as drivers of infection outcome

Henrique AL Ribeiro, Luis Sordo Vieira, Yogesh Scindia, Bandita Adhikari, Matthew Wheeler, Adam Knapp, William Schroeder, Borna Mehrad, Reinhard Laubenbacher

bioRxiv 2021.06.08.447590; doi: https://doi.org/10.1101/2021.06.08.447590

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