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Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine

Jacob Pitcovski, Nady Gruzdev, Anna Abzach, Chen Katz, Ran Ben-Adiva, Michal Brand Schwartz, Itamar Yadid, Hadar Haviv, Irena Rapoport, Itai Bloch, Roy Shadmon, Zohar Eitan, Dalia Eliahu, Talia Hilel, Morris Laster, Sigal Kremer Tal, Tamara Byk Tennenbaum, Ehud Shahar
doi: https://doi.org/10.1101/2021.06.09.447656
Jacob Pitcovski
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
cTel-Hai Academic College, Upper Galilee, Israel
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Nady Gruzdev
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Anna Abzach
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Chen Katz
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Ran Ben-Adiva
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Michal Brand Schwartz
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Itamar Yadid
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
cTel-Hai Academic College, Upper Galilee, Israel
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Hadar Haviv
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Irena Rapoport
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Itai Bloch
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Roy Shadmon
bMigVax Ltd
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Zohar Eitan
bMigVax Ltd
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Dalia Eliahu
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Talia Hilel
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
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Morris Laster
bMigVax Ltd
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Sigal Kremer Tal
bMigVax Ltd
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Tamara Byk Tennenbaum
bMigVax Ltd
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Ehud Shahar
aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
cTel-Hai Academic College, Upper Galilee, Israel
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  • For correspondence: ehudsha@migal.org.il
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Article Information

doi 
https://doi.org/10.1101/2021.06.09.447656
History 
  • June 9, 2021.
Copyright 
The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-ND 4.0 International license.

Author Information

  1. Jacob Pitcovskia,c,
  2. Nady Gruzdeva,
  3. Anna Abzacha,
  4. Chen Katza,
  5. Ran Ben-Adivaa,
  6. Michal Brand Schwartza,
  7. Itamar Yadida,c,
  8. Hadar Haviva,
  9. Irena Rapoporta,
  10. Itai Blocha,
  11. Roy Shadmonb,
  12. Zohar Eitanb,
  13. Dalia Eliahua,
  14. Talia Hilela,
  15. Morris Lasterb,
  16. Sigal Kremer Talb,
  17. Tamara Byk Tennenbaumb and
  18. Ehud Shahara,c,*
  1. aMIGAL Research Institute in the Galilee Kiryat Shmona, Israel
  2. bMigVax Ltd
  3. cTel-Hai Academic College, Upper Galilee, Israel
  1. ↵*Corresponding author: Ehud Shahar; email: ehudsha{at}migal.org.il
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Posted June 09, 2021.
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Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine
Jacob Pitcovski, Nady Gruzdev, Anna Abzach, Chen Katz, Ran Ben-Adiva, Michal Brand Schwartz, Itamar Yadid, Hadar Haviv, Irena Rapoport, Itai Bloch, Roy Shadmon, Zohar Eitan, Dalia Eliahu, Talia Hilel, Morris Laster, Sigal Kremer Tal, Tamara Byk Tennenbaum, Ehud Shahar
bioRxiv 2021.06.09.447656; doi: https://doi.org/10.1101/2021.06.09.447656
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Oral subunit SARS-CoV-2 vaccine induces systemic neutralizing IgG, IgA and cellular immune responses and can boost neutralizing antibody responses primed by an injected vaccine
Jacob Pitcovski, Nady Gruzdev, Anna Abzach, Chen Katz, Ran Ben-Adiva, Michal Brand Schwartz, Itamar Yadid, Hadar Haviv, Irena Rapoport, Itai Bloch, Roy Shadmon, Zohar Eitan, Dalia Eliahu, Talia Hilel, Morris Laster, Sigal Kremer Tal, Tamara Byk Tennenbaum, Ehud Shahar
bioRxiv 2021.06.09.447656; doi: https://doi.org/10.1101/2021.06.09.447656

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